authorities on amino acid metabolism. No hint is given concerning the origin, fundamental characteristics, or intended purDoses of the drawinas of amino acid crystals reproduced in Chaoter I . Important references t o the literature have been omittid particularly in Chapters 111, IV, and V. An essential amino acid is one required for nomal growth according to the definition on page 225. What is normal growth? Hegsted [ J . B i d . Chern., 156,247 (1944) I has defined an essential amino acid as one essential for life. Our views on this subject need clarification. Peptides, enzymes, physical properties of the amino acids, amino acid periodicity in proteins, structural models of protein molecules, microbiological assay of amino acids, and other topics have been neelected or have been treated too brieflv. A summarv of Pair's i1jt.l. Keu.. 15, t i + (1!)111! virns on thc criteria of purity of largc molrrulec of hiologicd origin ,~.ouldbc an apprupriate ndditior, to the dicrucsion o n page ti4 Thc chnptcr on protein rtructurecauld be expanded with profit if the author were t o emphasize more strongly some of his views ("Advances in Enzymology," 1941, Vol. 1, p. 11. This book has numerous commendable features including excellent orintine. errors. well-chosen -. freedom from tvDoera~hical . . .. . cubjcct matter, and a l k i - i n ~style. On the whole i t .hunlld mcrt the nerds of brgiming s t u d t n t ~llctlcr than any other ilvmlahlc
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NHa, 0 a 1 (51 pp.); Poisonous Compounds of the Halogens (20 p p ) ; Carbon Monoxide and Dioxide, Hydrocyanic Acid, Cyanopen (40 pp.); Combustible and Solvent Vapors (20 pp.); Organic Compounds [about 100 varieties] (195 pp.). The more important materials are discussed in considerable detail as to: (a)industrial incidence, (b) physiological response and toxicity, (c) detectionand estimation. Theanalytical procedures are taken from the original sources without critical comment or suggested preferences. No information regarding antidotes or treatments is given. There are numerous references t o the literature. The final chapter (40 pp.) is devoted t o chemical i warfare agents. The appendix contains a number of useful tables in which are assembled data on limits of inflammability and explosive ranges, physiological responses, probable safe concentration limits of exposure to gases. The mechanical make-up of the book is attractive. This text is a good buy. RALPHE. OBSPER UNIVERSITY OX
CINCINNATI
CINCINNATI, O ~ O
ANHYDROUS ALUMINUMCHLORIDEIN ORGANICCHEMISTRY. Charles Allcn Thomas. Central Research Director, Monsanto Chemical Company, in &llahoration with Mary Baluk Moshicr, Herbert E . Morris, and Ross W. Moshier, Thomas and Hochwalt Laboratories, Monsanto Chemical Company. American Chemical Society Monograph Series. Reinhold Publishing Corporation, New York. 1941. xiii 972 pp. 15.5 X 23.5 THEANALYTICAL CHEMISTRY OF INDUSTRIAL POISONS,HAZARDS cm. $15, After a short introduction and historical sketch of Friedel AND SOLVENTS. Morris B . Jacobs, Senior Chemist, Department of Health, City of New York. 1928-; Director of Gas and Crafts, a chapter is devoted to the chemical and physical Reconnaissance, Gas Defense Service, New York City; Citi- properties of anhydrous aluminum chloride itself and another t o zens Defense Corps. Second Revised Reprint. Interscience the various mechanisms which have been proposed to explain Publishrrs, Inc., New York. 1944. xvii 661 pp. 110 figs. its role in organic reactions. The next 12 chapters, which constitute the major portion of the book, give a detailed and orderly 34 tables. 15 X 23 cm. $7.00. This text was originally issued in 1941 and evidently met so account of the numerous reported instances of the use of aluminum chloride in reactions involving aromatic compounds. The cordial a welcome that this 1944 reprinting was required. Any literature of the more recent and Less well-known field of the use changes are so minor that the author did not deem i t necessary of aluminum chloride in aliphatic reactions is then surveyed with to include an additional preface. Consequently, the reviews of separate sections on polymerization and cracking. The two final the earlier issue are still applicable. Excellent detailed discussions were given by H. B. Elkins, Journal qflhe American Chemi- chapters are devoted to the manufacture and purification of cal Society. 63. 3544 (1941); N. M. Molnar. Chemical and En- anhydrous aluminum chloride and to the various factors;such gineering News, 20, 55 (1942); H . E.. Cox, The Analyst, 66, 477 as temperature, solvents, agitation, etc., which may modify its action. Subject, author, and patent indexes complete the (1941); M. G. Mellon, THISJOURNAL, 19, 50 (1942). Reviews of thisreprinting have been published by H . H. Schrenk, Journal book. There can he little doubt t h a t the authors have achieved to a of the American Chemical Society, 66,1993 (1944) and again by ronarrmndoblr srtent their exprrssed purpow of cullecting i n one H. E. Cox, The Analyst, 70, 36 (1945). placeallof thr widely scattered litcratureon thr urr of nnhydrous Under these circumstances, the present reviewer feels that his alur~linumchlorirlc in organic chemistry. Hou.t.vrr, in nrhieving competent predecessors have done his work for him. He, too, this completeness as a literature survey, the authors have denied has found here a wealth of information gathered together, for the themselves, for the most part, the opportunity of critically first time, from widely scattered sources, especially periodicals evaluating the work cited. As a consequence, the book will and government bulletins. The preface states: "The author be particularly useful to workers in the field of reactions involving hopes that this book will be a contribution to analytical chemthe use of aluminum chloride, but in its very completeness will istry in industrial hygiene. I t should be useful in industry, in- overwhelm those of more casual interest. Likewise, i t will be surance, education, gownmental regulation, research, hospitals, useful to advanced students as a reference work but will not and for chemists, toxicologists, and physicians." The reviewer readily lend itself to use as a textbook. hopes that it may be seen by students also, because they can M. F. ROY read here how to attack and solve problems that require the BEOWN UNIVERSITY sampling of dusts and atmospheres, and the subsequent deterPROVIDGNCB, RHODE ISLAND mination of their burden of toxic materials. Practically nothing is given relative to the chemistry of the various procedures, so CHEMISTRY.Louis F. Fieser and Mary Fieser. .%bridged that considereble reading, class discussions, and lectures would ORGANIC edition. D. C. Heath and Company, Boston. 1944. xi be required to adapt the text to pedagogical purposes. 698 pp. 22 figs. 61 tables. 20 charts. 15.5 X 23.5 cm. The scope of the text is indicated by the following partial syn$4.00. opsis: Sampling (25 pp.); Measurement of Gas Volume and I t is always pleasant when first good impressions continue Quantity (23 pp.); Absorbers and Absorbents (21 pp.); Chemical and Microscopic Estimation of Dust (44 pp.); Chemical throughout the reading of a book. Such were the feelings of the and Microscopic Estimation of Silica (25 pp.); Dangerous Met- reviewer as he turned the pages of this admirable book. It is an als [Pb, Hg, As] (44 pp.); Other Harmful Metals [Cr, Sb, Cd, abridged edition of the Larger work by the same authors but the Mn. Se, Va, TI, Zn, Cu, Sn, Ni. Alkalies, Radioactive sub- abridgment has been done so well that even one familiar with the stances] (35 pp.); Other Poisonous Compounds [H2S04,SOz, first work would not especially notice the condensation. The H,S. CS*. SzCI1, SOCIZ,SOnC12,COS, P , PCII. Nitrogen oxides. abridged edition consists of 33 chapters instead of 40 and of 698
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pages instead of 1091. Some of the essay chapters are omitted or condensed and combined, and paragraphs or groups of paragraphs are cut directly out of the larger text to make the smaller edition. This book is well written and gives an air of authority without any signs of pedantism. I t contains a tremendous amount of good theoretical and practical information, There are many references to the commercial uses of organic compounds as well as to laboratory processes of the preparation. Chemistry is a laboratory science and the discussions of reactions from the laboratory standpoint help chemists t o keep "one foot on the ground." Questions are given a t the ends of someaf the chapters, also references to the literature, chiefly and properly t o review articles. The book is up to date as evidenced'by the discussion of resonance, of the use of isotopic tracer elements in solving the courses of reactions, and of the structure and synthesis of biotin. Brief notes on the history of compounds, the derivationof names, and the biological significance of compounds, are excellent. Not only are these of general interest, they also help the student by association to remember facts. The book is full of structural formulas and they are very well done. Scarcely a page is noted without a t Least one, and this extensive use of the organic chemist's shorthand is worth while. Many tables of compounds and physical data are very helpful. The Geneva system of nomenclature is used considerably. The authors follow the older method of adding suffixes (hutened) instead of the more modern American Chemical Society method of prefixes (2-butene). The introductory chapter consisting of 24 pages on "The Kature of Organic Compounds" is a liberal education in the fundamentals of the subject, and the section on "Problems in Synthesis" is provocative of good thinking. Three hundred ninety-five pages cover aliphatic compounds and two hundred twenty-six, aromatic compounds. There are, of course, some overlapping subjects, such as the chapter on stereochemistry, and there are two closing chapters on "Synthetic Fibers and Plastics," and "Physiologically Active Agents." The aromatic compounds are adequately discussed, and the accent on aliphatic chemistry is desirable in these days. The arrangement or order of treatment of subjects may not be what might be considered regular, but the general subject is so well covered that the author's arrangement is scarcely open to question. There is a very good index, 32 pages of double columns. The typography of the book is excellent and errors must be very few sinceonly two, in spelling, were nated (pp. 79,648). HARRY L. Frsnen
500 to 5000 Angstroms thick mounted on a 1000-Angstrom collodion layer, or transferred to a polystyrene film; (d) recent models with improved vacuum technique, eliminating the special air-lack; (6) stereoscopic pictures. Happily this author does not view his popular science through roseate glasses, for in Chapter 4 he frankly states the limitations of the electron microscope: its lower limit of 15 Angstroms, too small to see common molecules; the destruction of specimens by vacuum, or by the searing and dehydrating effect of electron bombardment; and difficulties in preparing specimens. Chapter 5 reviews the historical development in this country down to the present portable models by RCA (electromagnetic focusing) and by G E (electrostatic focusing). Perhaps too little is said of the superb photographs once obtained in Europe. Chapter 6 discusses the pioneer researches by Columbia Carbon Co., revealing that particles of carbon black are round and smooth, and the importance of this in rubber chemistry; of the round and pear-shaped particles of rubber latex, 20 times larger in natural rubber; of grains of metallic smokes, round for aluminum, needles for zinc oxide. Industrial applications are treated in Chapter 7-the structure of wood pulp, textile fibers with dyes, photographic emulsions, clays and soils; and of the recent techniques for obtaining impressions on plastics. In Chaoter 8. we see clumsv bacteria outside the cells: viruses which penetrate and reproduce within the cell; leucocytes engulfing pneumonia germs, a bacteriophage attacking, penetrating, and finally destroying a streptococcus ceil; and individual molecules of tobacco mosaic virus. There is speculation on things yet to be discovered with cancer cells, and with genes. The concluding chapter peers briefly into the future, reiterating the shortcomingsof the new instrument. The author has performed a useful service both in collecting these pictures, most of which have already appeared in print, and in writing a story of our latest scientific prodigy. The story is a t times dull, explanations awkward, and statements inaccurate, but on the whole the volume should prove interesting to the young scientist andlayman. HUBERT N. ALYEA PRINC&TON UNm~Bsrn PIWCETON, Nsw JERSEY
EXPER~MENTS IN GENERALINORGANIC CHEMISTRY.J . L. Maynard and T . I. Taylor, Assistant Professors of Chemistry, School of Chemistry. University of Minnesota. D. Van Nostrand Comoanv. .. Inc.. New York. 1944. xi 554 oo. 101 U.S. I ~ n u s r a r *C~w ~ n c r ~ INC. s, figs. 17 X 24 cm. 'paper cove& spiral wire binding. perSTAMPOLD. CONNBCT~VT forated sheets. $2.90. This laboratory manual is designed t o accompany "General SEEING THE INVISIBLE. THE STORY OR THE ELECTRON MICROSCOPE.Gessner G. Hawley. Alfred A. Knapf, New York, 1945. Inorganic Chemistry" by Sneed and Maynard, although it may xv 196 ix pp. 12.5 X 18.5 cm. $2.50. Written for the he adapted t o accompany other textbooks. Fifty-five general layman, this little volume is the life history of our latest scien- experiments are included, together with qualitative analysis for twenty-two common cations according t o the scheme presented tific baby, the electron microscope. in "Semimiera Qualitative Analysis" by Barber and Taylor. Chapter 1, "The Search far the Small"--excites us to its The hook opens flat and occupies small desk space. The wonders: jagged particles of face powder magnified 47,800 times; system of recording results on separate pages indexed according pneumonia germs looking 35,000 times larger than nature in- t o the experiment is an admirable feature. A large appendix tended; studies on quick-setting cement for the Siegfried Line: includes a discussion of errors and logarithms. photographs of paper, textiles, and synthetic rubber for a nation The manual i.i relatively heavy for the flimsy covers. The at war; current practice of taking electron microscope pictures experiments are irregular in length. The first 22 of the 55 exwith 1000 t o 8000 times magnification, then photographically periments cover the topics of introductory principles, oxygen. enlarging to a hundred times the magnification achieved with the hydrogen, and water. Experimental directions, questions ordinary microscope. about observations, and reference questions are often included in Chapter 2, on "The Physics of Waves"--diffraction, resolving the same paragraph, sending the pupil frequently to the textbook power, and interference is poorly done, using oversimplifiedanalo- when writing his lahoratory report. The description of the exgies with water-waves-examples which confounded this re- perimental synthesis of copper sulfide (p. 83) differs radically viewer more than the phenomena themselves. from that given in the textbook. Small quantities of reagents Chapter 3, "How the Electron Microscope Works2'-includes are specified throughout. Normal or molar designations are many interesting details: (a) electrons from a hot filament oper- regularly made for the concentrations of liquid reagents, e. g., ated around 60.000 volts *l volt d. c. obtained from ordinary 36 N HsS04. 110-volt a,-=. house current; (b) electromagnetic focusing giving higher resolution and magnification than electrostatic focusina.
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