pH Switchable Nanoassembly for Imaging a Broad Range of

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pH Switchable Nano-Assembly for Imaging a Broad Range of Malignant Tumors Ye Liu, Zhuo Qu, Hongyan Cao, Hongyan Sun, Yuan Gao, and Xingyu Jiang ACS Nano, Just Accepted Manuscript • DOI: 10.1021/acsnano.7b06483 • Publication Date (Web): 01 Dec 2017 Downloaded from http://pubs.acs.org on December 1, 2017

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ACS Nano

pH Switchable Nano-Assembly for Imaging a Broad Range of Malignant Tumors Ye Liu1 ‡, Zhuo Qu1 ‡, Hongyan Cao1, Hongyan Sun1, Yuan Gao1 *, Xingyu Jiang1, 2 * 1

CAS Center for Excellence in Nanoscience, Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No.11 Zhongguancun Beiyitiao, Beijing 100190, P. R. China. 2 University of Chinese Academy of Sciences, Beijing 100049, P. R. China. Corresponding Author: [email protected]; [email protected]

ABSTRACT: Polymer-based fluorescent nanomaterials have proven to universally image various tumors based on its extremely sharp responsiveness to pH change. Such a property has never been realized in supramolecular system. We herein design a small molecule (DPP-thiophene-4) that is composed of a diketopyrrolopyrrole (DPP) core and two alkyl chains terminated with quaternary ammonium. DPPthiophene-4 can self-assemble into non-fluorescent nano-assembly when pH>7.0 but reversibly disassemble back to fluorescent monomers when pH