EDITOR'S PAGE
CHEMICAL & ENGINEERING NEWS 1155—16th St., N.W., Washington, DC 20036 (202) 872-4600 or (800) 227-5558 EDITOR-IN-CHIEF: Rudy M. Baum DEPUTY EDITOR-IN-CHIEF: Pamela S. Zurer MANAGING EDITOR: A. Maureen Rouhi ART DIRECTORS: Nathan Becker, Robin L. Braverman ASSOCIATE DESIGNER: Yang H. Ku STAFF ARTIST: Monica C. Gilbert SENIOR CORRESPONDENT: Lois R Ember NEWS EDITOR: William G. Schulz EDITOR-AT-LARGE: Michael Heylin SENIOR ADMINISTRATIVE OFFICER: Marvel A. Wills ADMINISTRATIVE ASSISTANT: Marilyn Caracciolo
BUSINESS Michael McCoy. Assistant Managing Editor NORTHEAST: (732) 906-8300. Lisa M. Jarvis (Associate Editor), Rick Mullin (Senior Editor), Marc S. Reisch (Senior Correspondent), William J. Storck (Senior Correspondent), Alexander H. Tullo (Associate Editor), Rachel Eskenazi (Administrative Assistant). HONG KONG: 852 2984 9072. JeanFrancois Tremblay (Bureau Head). LONDON: U 20 8870 6884. Patricia L. Short (Senior Correspondent)
GOVERNMENT & POLICY David J. Hanson, Assistant Managing Editor WASHINGTON: (202) 872-4495. Glenn Hess (Senior Editor), Bette Hileman (Senior Editor), Cheryl Hogue (Senior Editor), Jeffrey W. Johnson (Senior Editor), Susan R. Morrissey (Associate Editor)
SCIENCE/TECHNOLOGY/EDUCATION Doron Dagani, Assistant Managing Editor (Washington) BOSTON: (617) 395-4163. Amanda T. Yarnelt, Deputy Assistant Managing Editor WASHINGTON: (202) 872-6216. Ivan Amato (Senior Editor), Celia Henry Arnaud (Senior Editor), Stuart A. Borman (Senior Correspondent), Rebecca Evanhoe (Intern), Sarah Everts (Associate Editor), Bethany Halford (Associate Editor), Stephen K. Ritter (Senior Editor), Sophie L. Rovner (Senior Editor). CHICAGO: (847) 679-1156. Mitch Jacoby (Senior Editor). HOUSTON: (281) 486-3900. Ann M. Thayer (Senior Correspondent). WEST COAST: (510) 849-0575. Elizabeth K. Wilson (Senior Editor). LONDON: 441256 811052. Michael Freemantle (Senior Correspondent)
ACS NEWS & SPECIAL FEATURES Linda Raber, Assistant Managing Editor Corinne A. Marasco (Associate Editor), Rachel A. Petkewich (Assistant Editor), Linda Wang (Assistant Editor)
EDITING & PRODUCTION Robin M. Giroux, Assistant Managing Editor Janet S. Dodd (Senior Editor), Kimberly R. Dunham (Assistant Editor), Arlene Goldberg-Gist (Senior Editor), Faith Hayden (Assistant Editor), Melissa A. Kuhnell (Assistant Editor), Stephen M. Trzaska (Associate Editor)
C&EN ONLINE Rachel Sheremeta Pepling, Editor Tchad K. Blair (Visual Designer), Luis A. Carrillo (Production Manager), William B. Shepherd (Manager, ChemJobs)
PRODUCTION & IMAGING Renee L. Zerby, Lead Digital Production Specialist Krystal E. King (Senior Digital Production Associate) SALES & MARKETING Elise Swinehart, Manager Elaine Facciolli Jarrett (Marketing Manager) ADVISORY BOARD: Magid Abou-Gharbia, Kim Baldridge, Lukas Braunschweiler. Gary Calabrese, E. J. Corey, F. Fleming Crim, Marijn E. Dekkers. Michael P. Doyle, Robin L. Garrell, Rudolf Hanko, L. Louis Hegedus, Nancy B. Jackson, Harry Kroto, Sunil Kumar, Robert L. Lichter, Charles M. Lieber, Joseph A. Loo, Eli Pearce, Peter Pollak, Marquita M. Quails, Paul J. Reider, Sara J. Risch, Gregory H. Robinson, Alan Shaw, Kevan M. Shokat, Rakesh (Ricky) S. Sikand, Wilhelm Stahl, Joel Tickner, Guy Villax. Frank Wicks Published by the AMERICAN CHEMICAL SOCIETY Madeleine Jacobs, Executive Director & CEO Robert D. Bovenschulte, President, Publications Division EDITORIAL BOARD: Grace Baysinger (Chair); ACS Board of Directors Chair: James D. Burke; ACS President: E. Ann Nalley; Ned D. Heindel, Madeleine M. Joullie. Leah Solla, Peter J. Stang Copyright 2006, American Chemical Society Canadian GST Reg. No. R127571347
Pharmaceuticals And C&EN
T
HIS WEEK'S ISSUE IS C&EN'S ANNUAL
pharmaceutical issue, timed to coincide with the CPhI pharmaceutical ingredients exposition being held in early October in Paris. Four C&EN editors will attend CPhI to stay abreast of this dynamic segment of the chemical enterprise. A report on the exposition will appear in the Oct. 23 issue of C&EN. C&EN, of course, focuses on biomedical research and pharmaceutical developments—from fundamental research on new drugs to the health of the pharmaceutical and biotech industries—throughout the year. There are many reasons for this attention. The interface of chemistry and biology is one of the most vibrant areas of science, and research on new drugs to treat human disease is one of the most active and exciting areas of chemistry. The pharmaceutical and biotech industries are among the few industries where new jobs are being created for chemists. Another important reason is that, as you can tell by the heft of this issue, C&EN's largest source of advertising revenue is the fine and custom chemical manufacturers who produce the molecules that go into drugs. Advertising revenuesdisplay and classified—are critical to our ability to bring you this magazine each week. The allotment that C&EN receives from member dues, $34.99 this year, covers only the printing, paper, and distribution components of the costs of producing C&EN, about one-third of the magazine's expense budget. The remainder of that budget is covered by advertising revenue. To facilitate advertising sales, we produce an editorial calendar each year that outlines in very general terms some of featured stories that will appear throughout the year. We keep the calendar general—this issue is listed simply as "Pharmaceuticals"—so that the topics we actually write about are timely. That's certainly the case with this week's cover story on drugs to fight addictions, by Senior Correspondent Ann Thayer (see page 21). Like all serious journalistic enterprises, C&EN has a rigorous wall between editorial and advertising activities. C&ENs policy and ethics manual has a section on "Separation of Editorial and Advertising," which states: "The credibility of the editorial content of a
magazine hinges on a clear and recognizable division between editorial and advertising in the published product." Among the mandates that follow are "Advertising staff must not have access to copy prior to publication," and "Writers and editors should not supply advertising staff with details on which companies will be covered in an upcoming story." C&EN never provides editorial coverage in exchange for advertising. Of course, we cover the activities of companies that advertise in C&EN, but we cover them because they have done something newsworthy. In addition to Thayer's fascinating and comprehensive feature on efforts to develop pharmacotherapies to treat smoking and drug and alcohol abuse, this issue contains three Business Department stories that focus on various aspects of pharmaceutical R&D and business. Associate Editor Lisa M. Jarvis' "Arming Antibodies" (see page 51) examines the complex chemistry and pharmacology of antibody-drug conjugates (ADCs) to treat cancer. Since the advent of monoclonal antibodies 30 years ago, researchers have dreamed of linking a highly toxic small drug molecule to an antibody highly specific for a particular tumor cell. It's been a tough road. Jarvis explores how several companies have developed promising ADCs for a number of tumor types. Senior Editor Rick Mullin previews the CPhI exposition (see page 62). His story, "Indian Firms Go Global," looks at the strategies of several Indian companies in buying the high-cost fine and custom chemical assets ofWestern companies that are exiting the business. Finally, on page 66, Hong Kong Bureau HeadJean-Francois Tremblay provides a look into how the U.S. Food & Drug Administration inspects Indian and Chinese pharmaceutical manufacturing facilities for compliance with current Good Manufacturing Practices. Pharmaceuticals are an essential component of the chemical enterprise and of modern health care. C&EN is committed to keeping its readers well-informed of developments in this area. Thanks for reading.
Editor-in-chief
Views expressed on this page are those of the author and not necessarily those of ACS. WWW.CEN-0NLINE.ORG
C & E N / S E P T E M B E R 25, 2006
5
