(31T) Lyn, W. T., Engineer (London)215, 661 11963). (32T) hlalschaert, F. P., Mech. Power 58, 201-5 (1962). (33T) Rlelent’eva, N. I., Khim. z Tekhnol. Topliz: z Masel 8, No. 2, 62-3 (1963). (34T) Mozes, G., Fenyi, Rl., Fehervari, A,, Vamos, E., Acta Chim. Acad. Sci. Hung. 37, S o . 2, 191-202 (1963). (35T) Selson, W. L., Oil Gas J . 60, No. 53, 151 (1962). (36T) Ibzd., 61, Yo. 31, 109 (1963). (37T) Pasek. G. J.. Thodos. G.. J . Chem. Eng. Data’7, 21-6 (1962): ’ (38T) Pektemirov, G. K., ~Vovosti.\’eft. i Gaz. Tekhn. Seftepromysl. Delo 1962, s o . 11, 33-4. (39T) Rajeswaran, P., Kirk, P. L., Microchem. J . 6 , No. 1, 21-9 (1962).
(40T) Roelands, C. J. A., Vlugter, J. C., Waterman, H. I., J . Basic Eng. 85, 60110 (1963). (41T) Sanin, P. I., Bagrii, E. I., Petrov, A. A,, Nikitskaya, E. A,, Tsedilina, A. L.. 12’eftekhimiua3.835-44 (1963). (42T) Sant“ucri, L.- E.,’ Schmidt, R.’ J., Mater. Res. Std. 3, No. 5, 395 (1963). (43T) Schatt, W., Pietsch E., Chem. Tech. (Berlin) 15, X o . 5, 284-90 (1963). (44T) Stepanov, L. P., Stul’ginskaya, I. A., Tr. Vses. Ll’auchn.-Issed Inst. Metrol. 1962, No. 62, 5-23. (45T) Trowell, F., Taylor, H. G., Brown, W. J., Analyst 87, 677-83 (1962). (46T) White, H. T., 139th Meeting ACS, Division of Petroleum Chemistry, St. Louis, Mo., Symposium 6, No. 2C, 9-16 (1961).
(47T) Wickey, R. O., Chittenden, D. H., Hydrocarbon Process. Petrol. Rejner 42, XO.6, 157-8 (1963). (48T) Zaitsev, I. F., TsarevskiI, A. F., Zavodsk. Lab. 28, 1135-7 (1962). Standards
(1V) Am. Soc. Testing Materials, Philadelphia, Pa., “Book of Standards,” Parts 17 and 18, 1964. (2V) Am. Soc. Testing Materials-Institute of Petroleum, “Petroleum Measurement Tables,” Am. SOC.Testing Materials, Philadelphia, Pa., 1952. (3V) Institute of Petroleum, London, “Standar* for Petroleum and Its Products, 1964.
Pharmaceuticals and Related Drugs D. C.
Wirner, J. G. Theivagt, and
V. E. Papendick,
Analytical Research Department, Abbott laboratories, North Chicago, 111.
T
SURVEY includes analytical methods and related topics of pharmaceutical interest that have appeared since the last published review (197) and covers the literature to J u n e HIS
1964. T h e material has been arranged in the same tabular form as was used in the previous review; however, general papers on pharmaceutical siability and incompatibility are now indexed separately (see Table VI). Stability and degradation studies of individual compounds and/or classes may still be found in the appropriate table under the desired topic. .A number of review articles have appeared which are of interest to analytical chemists working in the d r u g field. Papers on thin layer chromatography and its application to pharmaceutical analysis continue to increase in number (233, 765, 1074, 1122, 1184). T h e use of grooved glass plates permits uni-
form application of silica gel or other materials without the use of elaborate spreading equipment (406). Comprehensive reviews of column partition chromatography (739) and gas chromatography (184) and their application in pharmaceutical analysis have appeared. Gas chromatography has been used to separate and identify a large number of tranquilizing drugs (957). Tschudi-Steiner and Leupin have reviewed the fluorescence analysis of drugs (1294). The possibility of using solid state fluorescence for the control of tablet uniformity was explored by Head (480). Phase solubility analysis may be used for determining the purity of compounds suspected to contain structurally similar impurities (939). The slope of the total concentration us. the solubility concentration curve can be related t o drug purity. T h e dissolution behavior and the effect of hydration and solva-
Table I.
Compound or class Method or subject Alkaloidal amines Colchicine Polarographic, stability Ephedrine Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper Colorimetric Counter-current distribution Extractive, mise. Identity Volumetric, acid-base Volumetric, complexometric Muscarine Chromatographic, paper Alkaloids, general Chromatographic, column
Reference (961) (1369) (141)
tion on the solubility and rate of solution of drugs have been evaluated from a theoretical standpoint (@2, 1138). An evaluation of oral sustained release formulations based on the principle of delayed diffusion has been made (1153). T h e identification of drugs continues to receive considerable emphasis. A compilation of the infrared, ultraviolet, and visible absorption spectra of some U.S.P. and K.F. reference standards and their derivatives has been published (478). Over 200 spectra are included. Sunshine and Gerber have written a book on the Spectrophotometric Analysis of Drugs (2264). An atlas of spectra is included. The control applications of ultraviolet and infrared spectrophotometry have been reviewed (892). Microscopic identification of drugs has been studied including some of the factors which influence crystal formation from solutions (896). (Text continued on page 199 R )
Alkaloids
Compound or class
Method or subject Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper
( 495 )
(1286) ( 660 )
( 172, 173) (302, 1361) (141, 240, 546) (1297) (194) (28, 139, 970)
Chromatographic, partition column Chromatographic, thin layer
Reference (188, $97, 622, 959) (1448) (291, 297, 332, 707, 856, 1049, 1210, 1293, 1355, 1377, 1393, 1443, 1458) (195) (318, 367, 683, 690 )
(Continued)
VOL. 37,
NO. 5, APRIL 1965
185 R
Table I. Alkaloids (Continued) Corn oundor &ass
Method or subject Colorimetric
Electrophoretic Fluorometric Identity Polarographic Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, complexometric Volumetric, conductometric Volumetric, radiometric T701umetric, colorimetric Glyoxaline alkaloids General Pilocarpine Indole alkaloids Ajmaline
Brucine
(79, 231, 332, 444, 893, 1038, 1286, 1413) (32, 956, 1261 ) (722, 734) (302, 1038) (1093, 1094) (446)
Chromatographic Electrophoretic, turbidimetric Polarographic Spectro hotometric StereocKemistry Chromatographic paper
Electrophoretic Spectrophotometric, ultraviolet Stability Tyolumetric. acid-base Chromatugraphic*,paper Chromatographic, partition column Colorimetric
Countercurrent distribution Identity Review, colorimetric Stability Volumetric, acid-base Ergot alkaloids Chromatographic, paper
Indoles, general Physostigmine
Rauwolfia alkaloids
(559) (765) (69)
(149,387, 794, 1003, 1098, 1293 ) (231, 365. ' 1098)
(17, 18, 20, 743, 1239, 1366) (109) ( 302 ) (1366) (1183) (1239) (19, 638, 743, 778) (742, 1381 )
Chromatographic, partition column Chromatographic, thin layer 1.652) (19, '313, 638, Colorimetric 743, 828) Countercurrent distribution Detection of clavine in Review, critical (464) (1208) Stabilitv Chromatographic, paper ( 7 , 8, 9, 887) (8) Colorimetric Fluorometric (66% 1414) Spectrophotometric, ultra(652) violet Stability ( 7 , 8 , 9, 387) Chromatographic, paper (1008) Chromatographic, paper; - . ~. misc. Identity Polarographic St abilitv Chromatographic, paper Chromatographic, thin layer Review Spectrophotometric, ultraviolet
186 R
Reserpine
Strychnine
(128, 240, 1023, 1178) (150, 1297) ( 1230) (1155) (676)
[;:;A)
Ergot, hydrogenated
Compound or Class
ANALYTICAL CHEMISTRY
(1117, 1377)
(607; 681, 766, 1003) (766) (1080) (606, 607, 766)
Method or subject Stereochemistry Volumetric, acid-base Colorimetric Coulometric Fluorometric Refractometric Spectrophotometric T. olumetric Chromatographic, ion exchanee Chromatougraphic, paper Chromatographic, partition - column Colorimetric
Chromatographic, paper Colorimetric Chromatographic, paper Colorimetric Identity
Colorimetric
Ergotamine
Reference
Strychnos alkaloids Yohimbine
Isoquinoline alkaloids Apomorphine Berberine
Chelidonine Codeine
Electrophoretic Extractive Identity Spectrophotometric, ultraviolet Stability Volumetric 1-olumetric, acid-base Volumetric, complexometric Volumetric, radiometric Chromatographic, paper Chromatographic, paper; thin layer Fluorometric Spectrophotometric Volumetric Volumetric, ox.-red. Colorimetric Chromatographic, ion ex change Electrophoretic Volumetric T'olumetric, complexometric I'olumetric, ox-red. Volumetric, acid-base Chromatographic, absorption column Chromatographic, gas Chromatographic, paper
Chromatographic, partition column Chromatographic, thin layer
Reference (69) (73) (169, 723) (697) (668)
(918) (766) (858) (1400) (149, 794, 1003, 1098, 1293, 1390) (737) (71, 231, 270, 454, 1098) (270, 271 ) ( 298 1 (302)
(737, 983) (1098) (160)
(220, 366) (1297) (83) (794)
(756) V47) (27, 766) (160) (1447) (1285) (1397, 1398, 1400) (1420) (978)
(1397) (1399) (669) (28, 996) (1369, 1432) (289, 361, 664 880, 971, 995, 1213, 1293) (678, 680)
(126, 379, 799, 1236 ) Colorimetric (169, 231, 366, 1013, 1273) Extractive, misc. (17%) Fluorometric (256) Gravimetric (1013) Identity ( 900 1 Refractometric (104.2) Spectrophotometric, infrared (441 ) Volumetric, acid-base (201, 440, 673 982, 1347, 137%) Volumetric, high frequency (36, 433) X-ray diffraction ( 1087) Cotarnine Fluorometric ( 629 ) Cryptopine Nuclear magnetic resonance (1072) DiacetylChromatographic, paper (880)' morphine Identity (400, 784, 834) Spectrophotometric, infrared (834) Spectrophotometric, ultra(879) violet Diamorphine Chromatographic, gas ( 1369) Dihydrocodeine Chromatographic, partition (678, 738) column Colorimetric (1083, 1084) Spectrophotometric ( 738)
Table 1. Alkaloids (Continued) Compound or Com ound or class Method or subject Reference cPass Colorimetric Uihydrohy( 1286) droxySpectrophotometric, ultra(724) violet codeinone Ethylmorphine Chromatographic, thin layer Extractive, misc. Spectrophotometric, ultraviolet Yolumetric, acid-base Electrophoretic, gel Hydrastine Salsoline Volumetric Tecodine Morphine Chromatographic, adsorption Thebaine column Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper (289, 361, 460, 664, 668, 880, 1293) Chromatographic, partition (680) column Chromatographic, thin layer (379, 799) Colorimetric 1231. 33L. 610. 668, 8g3, ’ Isoquinoline, bis1013, 1039, benzyl, alkaloids 1086, 1164 Colorimetric, psuedomorphine in Electrophoretic, paper Extractive Fluorometric Gravimetric Identity
Narcotine
Opium alkaloids
Nuclear magnetic resonance Polarographic Review Spectrophotometric, infrared Spectrophotometric, ultraviolet Volumetric Volumetric, ox.-red. Chromatographic, adsorption column Chromatographic, gas Chromatographic, pa.per Chromatographic, thin layer Colorimetric Fluorometric Gravimetric Identity Stability Volumetric Activation analysis of metals
( 179; 266)
(66, 181, 994, 1013 ) (216, 400, 611, 734, 1446) ( 929 1 illl6’)
(1446) (10, 289) (799, 1018 ) (231,1013, 1086) (266)
Pyridine alkaloids Hemlock alkaloids Lobelia alkaloids
(1013)
(1446) (10)
(978)
111
Quinoline alkaloids Cinchona alkaloids Qui n ci n e
Chromatographic, partition column Chromatographic, thin layer (799,1018) Colorimetric (883, 1039) Determination (1040) Fluorometric Gravimetric Identity Spectrophotometric, infrared Stability Colorimetric Chromatographic, adsorption column Chromatographic, gas Chromatographic, paper Chromatographic, thin layer
iE4)
Colorimetric Compatibility Electrophoretic, paper Extractive, misc. Fluorometric Gravimetric Polarographic
Tubocurarine Lupinane alkaloids General
Sparteine
Chromatographic, paper
Oxymorphine Papaverine
Ipecacuanha alkaloids
Quinidine
Quinine
Method or subject Spectrophotometric, ultraviolet Stability Volumetric Volumetric, acid-base Volumetric, complexometric Volumetric, high frequency Identity Identity Chromatographic, adsorption column Chromatographic, ion exchange Chromatographic, paper Chromatographic, thin layer Colorimetric; gravimetric Determination Fluorometric Nuclear magnetic resonance of cryptopine in Volumetric, acid-base
Reference
(lo.&,
1178, 1348) (978, 1462)
Stability Chromatographic, partition column Colorimetric Fluorometric Identity Chromatographic, partition column Colorimetric Polarographic Fluorometric Chromatographic, ion exchange; paper Electrophoretic, paper Xephelometric Identity Volumetric, acid-base
(447) ( 887 1
Chromatographic, gas Chromatographic, thin layer Autoisomerization Chromatographic, paper Colorimetric Spectrophotometric Volumetric, acid-base Chromatographic, paper Volumetric, acid-base Volumetric, thermometric Chromatographic, paper Colorimetric, polarographic Chromatographic, thin layer Fluorometric Identity Volumetric, thermometric Chromatographic, adsorption column Chromatographic, ion exchange paper Chromatographic, paper Chromatographic, thin layer Colorimetric Electrophoretic Fluorometric Gravimetric Identity
(149, 1229) (1287)
(177, 579) (231,270,454) (270,271,1420)
Spectrophotometric, ultraviolet Stability Volumetric, acid-base Volumetric, complexometric
VOL. 37, NO. 5 , APRIL 1965
187 R
Table 1. Compound or class Steroidal alkaloids Solanaceae alkaloids lreratensine Veratrine
Method or subject Volumetric, ox.-red.
(601 )
Colorimetric
( 444 )
Alkaloids (Continued)
Reference
Compound or class
Hyoscine
Colorimetric Colorimetric Countercurrent distribution
Tropane alkaloids Atropine Chromatographic Chromatographic, adsorption column Chromatographic, ion (1398) exchange Chromatographic, paper (300, 632, 668, 1293) Chromatographic, partition (1096) column Chromatographic, thin layer (643, 1268) Colorimetric (231. 668. Electrophoretic, paper Extractive Fluorometric
Hyoscyamine
Norhyoscyamine Scopalamine
Tropane, general
Identity
Cocaine
Homatropine
Stability Volumetric Volumetric, acid-base Volumetric, complexometric Volumetric, high frequency Chromatographic, gas Chromatographic, paper Colorimetric Identity Stability Chromatographic, paper; turbidimetric
i1293.’ 1377) Tropic acid, tropine
Table II. Compound or class
Method or subject
Chromatographic, ion exchange Chromatographic, column Actinomycin Actinospectacin Chromatographic, column Spectrophotometric, ultraviolet Stability Volumetric. acid-base Chromatographic, ion Amphomycin exchange Amphotericin Colorimetric Gravimetric Bacitracin Stability Bioautographic Cephalosporins Chloramphenicol Chromatographic, column Colorimetric Identification Polarographic Spectrophotometric, infrared Spectrophotometric, ultra-violeC Stability Volumetric, general Volumetric, precipitation ChlortetraChromatographic, ion exchange cycline Chromatographic, paper Chromatographic, thin layer Colorimetric Actinoidin
Coiilometric Extractive Identification Oscillographic Spectrophotometric, ultraviolet Stability
188 R
ANALYTICAL CHEMISTRY
Reference (180)
Compound or class Erythromycin
General
(239)
(811)’
(469, 11366)
(138-4)
Reference (1236) (49) (302, 797) ( 1398)
Chromatographic, ion exchange Colorimetric Identity
(1398)
Stability Chromatographic, paper
(1096) (1431) (300, 667) (1095) (1310)
(557, 633, 797) (991 1
(703, 720) ( 633 1
11286)
(302, 633, 797, 990, 1446) (720) (300, 633, 787, 1126) (1096)
Chromatographic, partition column Chromatographic, thin layer (543, 1268) Colorimetric (787, 1121, 1126) Countercurrent distribution (1310) Electrophoretic, paper ( 762 1 Extractive (172, $61, 1029 Identity i7,97l Review, critical i68) ’ Stability ( 1208) Stability (99, 100) Volumetric, acid-base (100)
Antibiotics
(1113) (111) (417)
(1306) (1480) (46, 736)
Method or subject Chromatographic, thin layer Colorimetric Identity Chromatographic, ion exchange Chromatographic, partition column Colorimetric, electrophoretic Chromatographic, paper Chromatographic, partition column Countercurrent distribution Identity Extractive Stability Identity
Magnamycin Monomycin Nafcillin Neomycin
Novibiocin Nystatin
Method or subject
Reference
Chromatographic, paper Colorimetric Identification Spectrophotometric, ultraviolet Volumetric, conductometric Chromatographic, pH Chromatographic, thin layer Identification Polarographic Review Turbidimetric Chromatographic, partition Colorimetric Polarographic Spectrophotometric, ultraviolet Chromatographic, column Chromatographic, ion exchange Chromatographic, paper Colorimetric Chromatographic, pH Chromatographic, ion exchange Specifications Chromatographic, ion exchange Chromatographic, thin layer Colorimetric Identification Polarographic Chromatographic, paper Colorimetric Identification (Continued)
Table 11. Compound or class Oleandomycin Oxytetracycline
Penicillins
Method or subject Spectrophotometric, ultraviolet Chromatographic, column Chromatographic, paper Chromatographic, thin layer Colorimetric Coulometric Identification Oscillographic Polarographic Stability Chromatographic, exchange Chromatographic, Chromatographic, Chromatographic, Colorimetric Review
Antibiotics (Continued)
Reference (398)
Compound or class Streptomycin
(693) (217, 1246) ( 609 ) (13, '692, 693, 1066,1311) (602)
(1270)
ion Streptovitacin Syntomycin Tetracycline
paper pH thin layer
S'olrimetric, acid-base Volumetric, ox.-red.
S taphylomycin
Stability Gravimetric Identification Volumetric, amperometric Spectrophotometric, ultraviolet Chromatographic, column Chromatographic, thin layer
Table 111. Compound or class Aluminum Ammonia Antimony Arsenic
Bismuth
Method or subject Volumetric, complexometric Identification Volumetric, photometric X-ray analysis Colorimetric Identification Volumetric, ox-red. Colorimetric Gravimetric Identification Volumetric, complexometric
Volumetric, ox.-red. Colorimetric Volumetric, acid-base Bromine Identification Radiometric Calcium Colorimetric Nephelometric Review Volumetric, complexometric Chlorine Gravimetric Copper Colorimetric Volumetric Fluorine Identification General, cations Volumetric, complexometric Halogens, general Identification Volumetric Heavy metals, Identification general Radiometric Volumetric X-ray analysis Iodine Colorimetric Volumetric, ox.-red.
Boron
Chromatographic Chromatographic, ion exchange Colorimetric Conductometric Fluorometric Identification Polarimetric Polarographic Spectrophotometric, ultraviolet Stability Volumetric, ox-red. Stability Colorimetric Chromatographic, paper Chromatographic, thin layer Colorimetric
Reference
(1137)
(44)
(370) (636, 1031 ) (1290)
(13, 691, 1066, 1311)
Extractive (1383) Fluorometric (479) Identification (1270) Oscillographic Polarographic Spectrophotometric, infrared Spectrophotometric, ultraviolet
Spectrophotometric, infrared (940) Spectrophotometric, ultra(886, 1403) violet Stability
Phenethicillin Polymyxin Primycin Rifamycin Sparsomycin
Method or subject
Trichothecin Tubercidin Tyrocidin Viomycin
Stability Volumetric Polarographic Spectrophotometric, ultraviolet Colorimetric, review Chromatographic, paper Colorimetric Gravimetric
Inorganic and Metal-Organic Compounds Reference (686, 686) (998) (1131)
(iizsj
(566, 708, 746) (137, 274, 1362) (1141) (434, 683, 964, 999) (1268, 1264) (1302) ( 6 1 , 62, 113.2, 1460) (387,466) (1071) 96L i (1110)
(733) (1424) ( 1062) (566, 936) ( 1863)
Com oundor cpass Iodine, organic
Method or subject Nolumetric, ox.-red.
Reference (706, 738, 817, 1103)
Iron
Review Volumetric Volumetric, complexometric Volumetric, ox.-red. Lead Volumetric Magnesium Volumetric, complexometric Mercury Colorimetric Kinetic Volumetric, complexometric Volumetric, ox.-red. Mercury, organic Bioassay Chromatographic, paper Gravimetric Polarographic Volumetric, complexometric Nitrate Identification Nitrite Identification Phosphorus Volumetric, complexometric Potassium Silver Sodium
Sulfate Sulfur Zinc
Gravimetric Identification Volumetric, ox.-red. Gravimetric Identification Nephelometric Volumetric, complexometric Volumetric, precipitation Gravimetric Identification Colorimetric Volumetric Volumetric, complexometric
VOL. 37, NO. 5, APRIL 1965
0
189 R
Tat,le IV. Compound or class
Nitrogen-Containing Compouindr Com oundor cyass
Method or subject
Acridines Amides
Chromatographic, paper Characterization Chromatographic, ion exchange Colorimetric
Sympathomimetic amines
Hydrolysis kinetics Polarographic Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, ox.-red. Volumetric, acid-base
Amino acids Amino acids (general)
Amidines Amines Aliphatic Spectrophotometric, ultraamines violet Antihistamine ?S Chromatographic, adsorption Chromatographic, gas Chromatographic, paper
Volumetric, precipitation Chromatographic, ion exchange Chromatographic, paper Colorimetric Gravimetric Spectrophotometric, ultraviolet Volumetric, acid-base Gravimetric Volumetric, acid-base
Phenylalkylamines
Piperazines Piperidines
. Procaine and analogs
Pyridines
196 R
Chromatographic, gas Chromatographic, paper Colorimetric Identification Polarographic Volumetric, acid-base
(36, 104, 170) (241) (241, 621, 812, 963)
Volumetric, ox.-red. Colorimetric Gravimetric Identification Polarographic Spectrophotometric, infrared Spectrophotometric, ultraviolet Stability Volumetric, acid-base l'olumetric, amperometric Chromatographic, paper Colorimetric (1102) Electrophoretic ( 1223) Gravimetric ( 1223)
ANALYTICAL CHEMISTRY
Chromatographic, Chromatographic, exchange Chromatographic, Chromatographic, Colorimetric
Epinephrine and analogs
Isoprenaline Meth ldopa andYanalogs Phenylephrine Azepines
Barbiturates
Reference
(474) (813)
(186, 187, 282, 968) (958, 1154) (237, 1271, 1872) (1161)
general ion
(210) (396, 898)
paper review
( 135, 284, 866) (210) (117,' 165, 158, 167, 21 9, 285, 1052) (1319, 1460)
p-hminosalicylic acids and salts Glycine Colorimetric Nucleic acids Spectrophotometric, ultraviolet Taurine Identification Thyronine and Biological assay analogs Chromatographic, ion exchange Chromatographic, paper Colorimetric Electrophoretic, 1 1 3 1 Aminoalcohols Ephedrine Identification N-AminobarSpectrophotometric, infrabituric acids red Aminophenols Adrenaline and Chromatographic, paper analogs Chromatographic, thin layer Fluorometric Spectrophotometric, chelates Stability Volumetric, ox.-red. Aminophenol Colorimetric
Chromatographic, paper Polarographic Chromatographic, paper Colorimetric Fluorometric Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, compleximetric
Nitrogenous organic bases
Identification Spectrophotometric, ultraviolet Volumetric, amperometric
Identification Polarographic Spectrophotometric, ultraviolet Stability Chromatographic, paper Chromatographic, thin layer
Chromatographic, partition Colorimetric Gravimetric Spectrophotometric, ultraviolet Thermomicroseopic Volumetric, acid-base Volumetric, compleximetric Volumetric, ox.-red.
Aromatic amines Morpholines
Method or subject Spectrophotometric, ultraviolet Volumetric, acid-base Chromatographic, gas
(429, 1096) ( 1 338)
(1389) (467, 1392) (61, 676, 943)
Chromatographic, adsorption Fluorometric Review Stability Volumetric, complexometric Spectrophotometric, chelates Stability Colorimetric Colorimetric Stability (to oxidation) Colorimetric Gravimetric Identification Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, compleximetric Chromatographic, gas Chromatographic, paper
(613, 647, 649, 1009, 1,901, 1206, 1212, 1436 1 (Continued)
Table IV. Com ound or cf’ass
Method or subject Chromatographic, ion exchange Chromatographic, thin layer
Barbiturates silver salts Benzoxazines Carbamates Ethylenimines Guanidines Hydantoins Hydrazides
Hydrazines
Imidazoles Imidazolines
Imides
Indantriones Ninhydrin Indoles Indolines Isoxazolidones Nitro
Oxazolidines
Nitrogen-Containing Compounds (Continued) Reference ( 605 )
(341, 1100, 1826 ) (286, 290, 768) Colorimetric Differentiation (microscopic) ( 856 ) Identification (185, 889, 1201, 1225) Refractometric (835, 836, 837) Review (methods) (161) Spectrophotometric, infrared ( 9 6 7 ) Spectrophotometric, ultra(156, 596, violet 1278. 1280) Spot tests (30, 4 f 5 , 644, 645,646, 648, 650, 651, 757, 1283, 1328) Stability and degradation (1190, i402, 1L53) Volumetric, acid-base ( 16,’ 142, 1054, 1238) Volumetric, compleximetric (138, 140, 263, 264, 1041) Volumetric conductimetric Volumetric, coulometric Volumetric, photometric Stability X-ray diffraction Spectrophotometric, ultraviolet Colorimetric (112, 881) Spectrophotometric, infrared (123) Volumetric, acid-base (212,1172) Volumetric, acid-base (1077) Colorimetric (899, 1148) Volumetric, compleximetric ( 1030) Volumetric, precipitation (699, 1030) Colorimetric (12, 1296, 1461) Fluorometric (853) Volumetric, acid-base ( 727,’ 1171 ) Volumetric, compleximetric (1266, 1267) Volumetric, coulometric ( 84%1 Volumetric, ox.-red. (1827) Colorimetric Volumetric, coulometric, tablet variation Volumetric, ox.-red. Polarographic Volumetric, acid-base I’olumetric, ox.-red. Crystallographic Identification Spectrophotometric, ultraviolet Colorimetric Degradation kinetics Identification I’olumetric, acid-base Anomalous reactions Colorimetric Volumetric, ox.-red. Colorimetric Colorimetric Gravimetric Spectrophotometric, ultraviolet Stability Colorimetric Electrophoretic Spectrophotometric, ultraviolet
Compound or class N-Oxides Purines and derivatives Pyrazines and derivatives Pyrazolidines Pyrazolones Aminopyrine
Antipyrine
Pyrazolones (general)
Pyrimidines Pyrroles Quaternary ammonium compounds
Method or subject Colorimetric Volumetric, acid-base Volumetric, ox.-red. Chromatographic, paper Chromatographic, thin layer Colorimetric Degradation (oxidation) Volumetric, ox.-red. Gravimetric Identification (microscopic) Review (methods) Spectrophotometric, Raman Stability Volumetric, acid-base Volumetric, compleximetric Chromatographic, paper Colorimetric Gravimetric Volumetric, compleximetric Volumetric, ox.-red. Chromatographic, paper Gravimetric Identification Spectrophotometric, ultraviolet Volumetric, ox.-red. Colorimetric Polarographic Stability Colorimetric Chromatographic, ion exchange Chromatographic, paper Colorimetric
( 455 1
(114) (721) (316) (500, 7 2 1 ) ( 1565) (325) (5) (1233)
Identification Polarographic Review (methods) Spectrophotometric, infrared Spectrophotometric, ultraviolet Stabilization and decomposition Volumetric, acid-base ( 7 8 , 473, 694, 1168)
Quinolines Sydnones Tetrazoles Uracils Urea and derivatives
Xanthenes Xanthines
Volumetric, ox.-red. Gravimetric Spectrophotometric, ultraviolet Stability Chromatographic, gas Colorimetric Volumetric, acid-base Colorimetric Complexes Identification Volumetric, acid-base Volumetric, ox.-red. Decomposition and stabilization chromatographic, paper Colorimetric Isotope dilution Volumetric, acid-base Volumetric, amperometric Volumetric, coulometric T‘olumetric, ox.-red. Volumetric, precipitation
(745, 816) (174) (595, 901 ) (1008, 1032) (975, 976)
VOL. 37, NO. 5, APRIL 1965
191 R
Table V. Compound or class
Method or subject
Acids and derivatives Acetyl salicylic Chromatographic, gas acid Colorimetric Decomposition General Spectrophotometric, infrared Spectrophotometric, ultra- violei Stability Carboxylic acids, aliphatic
Carboxylic acids, aromatic
Esters
Carbohydrates
Coumarins
Dextrin Ethers Fats and oils
Glycerides Glycosides Aloin and emodins
Cardiac glycosides Digitoxin
Flavones
192 R
Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper Colorimetric Spectrophotometric, infrared Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, ox.-red. Chromatographic, gas chromatographic, paper Colorimetric Coulometric Gravimetric Spectrophotometric, infrared Spectrophotometric, ultraviolet Volumetric, precipitation Colorimetric Review Stability Volumetric, acid-base \.olumetric, precipitation Aquametric Chromatographic paper Dialysis Microscopic Volumetric, ox.-red. Chromatographic, column chromatographic, paper Chromatographic, thin layer Polarographic Spectrophotometric, ultraviolet Solubility analysis Chromatographic, gas Chromatographic, gas Chromatographic, paper Chromatographic, thin layer Peroxide number Chromatographib, thin layer Colorimetric Chromatographic, paper Chromatographic, thin layer Colorimetric Polarographic Spectrophotometric, ultraviolet Stability Chromatographic, paper Colorimetric Electrophoresis Luminescence Chromatographic, paper Chromatographic, thin layer Colorimetric Fluorometric Review Chromatographic, paper Chromatographic, thin layer Colorimetric Coulometric Identification Polarographic Spectrophotometric, ultraviolet Stability
ANALYTICAL CHEMISTRY
Oxygen-Containing Compounds
Reference
Compound or class General
(279) ( 303 1
Method or subject Chromatographic, paper Chromatographic, thin layer Colorimetric
(705, 907) (283)
(414) (716)
(617, 704, 706, 747, 907) (640) (1461) (616, 1036, 1065)
(883, 1690) (160)
Santonin Saponin Squill glucosides Strophanthin
(516, 1089)
Gravimetric Identification Spectrophotometric, ultraviolet Colorimetric Chromatographic, paper Chromatographic, thin layer Spectrophotometric, ultraviolet Chromatographic, paper Chromatographic, thin layer Colorimetric
Reference ( 775 )
(368, 631, 1037) (369, 612, 775 826,1073, 1112, 1156, 1382) (514) (1017) (130, 9 4 f )
Polarographic Stability Hydroxyl, alcoholic Chelidonine Chloral hydrate Ethanol
Ethchlorvynol General 4Hydroxymethyl-1,3dioxolanes Mephenesin Hydroxyl, phenolic Aminophenols Bithionol Cresols Eugenol General
(rok5, 1220) (31)
(687) (67, 619, 1387) (1387)
Hexestrol Phenolphthalein Quinolinols Resorcinol Thymol Thyroxine Hydroxyl, polyhydric
Ketones
Q'uinones
Extractive Stability Distillation Identification Refractometric T.olurnetric, ox.-red. Colorimetric Chromatographic, gas Gravimetric Gravimetric Volumetric, ox.-red. Fluorometric
(175)
Chromatographic, paper Colorimetric Spectrophotometric, ultraviolet Chromatographic, gas Colorimetric Chromatographic, thin layer Identification Review Spectrophotometric, ultraviolet Colorimetric Spectrophotometric, ultraviolet Colorimetric
(1126) (127) (844)
Gravimetric Volumetric, complexometric Amperometric Colorimetric Volumetric, ox.-red. Chromatographic, gas Chromatographic, thin - layer Colorimetric Polarimetric Review Volumetric, acid-base Volumetric, ox.-red. Chromatographic, gas Chroma tographi c, paper Chromatographic, thin layer Polarographic Refrartometric Spectrophotometric Spectrophotometric, ultraviolet Chromatographic, thin layer Colorimetric
(26) (932) (870) (1386) (822) (396) (110)
(620)
(868, 1386) (1099, 1124) (1159) (1175) (360, 728, 1089) (94, 671) (717 ) (82, 1866)
Table VI. Compound or class
Table VII.
Stability (General)
Metho&or subject
Drug stability
Kinetics of
Parenterals Pharmaceuticals
Incompatibilities of Preservative loss in Accelerated stability Incompatibilities of
Rubber closures Stability Tablet formulations
Effect on preservatives Prediction of Photostability of
Reference (409, 457, 637, 670) (1053) (715) (579) (342, 846, 9661 966, 1291 ) (712) (669) (366, 713, 714)
Com oundor cPass Estriol
Estrone
Ethinyl estradiol General
Table VII. Compound or class
Steroids and Hormones Method or subject
Reference Ethisterone
Adrenocorticals Aldosterone
Chromatographic, gas Chromatographic, thin layer (101,' 198, 682) Fluorometric (483) Cortisones Chromatographic, gas Chromatographic, thin layer Colorimetric Electrophoretic Polarographic Spectrophotometric, ultraviolet Stability DexamethaChromatographic, thin layer sone Spectrophotometric, infrared Epicortisol Chromatographic, paper Colorimetric Fluorocortisone Identification General Chromatographic, paper Chromatographic, thin layer Polarographic Hydrocortisones Prednisolone
Prednisone
Triamcinolone
Androgens Androsterone General Methandrostenolone Nandrolone Testosterones
Estrogens Estradiol
Review (328) Chromatographic, paper (363, 807) Chromatographic, thin layer ( 5 7 5 ) Polarographic (517, 702) Chromatographic, thin layer ( 5 7 3 ) Colorimetric (213, 8-49) Dissolution rates Polarographic Solubility Chromatographic, thin layer Colorimetric Polarographic Colorimetric Identification Polarographic Spectrophotometric, infrared Polarographic Chromatographic, paper Chromatographic, thin layer Fluorometric
(647) (226) (749) (1279)
Colorimetric Identification Chromatographic, column Chromatographic, paper
(24) (24) (629) (5'85, 869, 1199) Chromatographic, thin layer ( 2 3 5 ) Colorimetric (225, 299) Fluorometric (1198) Spectrophotometric, ultra(629, 869, violet 1199) Chromatographic Chromatographic, column Chromatographic, paper Chromatographic, thin layer Fluorometric Stability
Insulin
Keto steroids
Method or subject Chromatographic Chromatographic, column Chromatographic, paper Fluorometric Chromatographic Chromatographic, column Chromatographic, paper Chromatographic, thin layer Fluorometric Chromatographic, paper Colorimetric Fluorometric Stability Chromatographic, gas Chromatographic, paper Chromatographic, thin layer Color reactions Chromatographic, column Spectrophotometric, ultraviolet Bioassay Chromatographic, paper
(345) (508, 1150,
Polarographic Chromatographic, gas Chromatographic, gradient elution Chromatographic, paper Chromatographic, thin layer Colorimetric Identification Polarographic Spectrophotometric, infrared Spectrophotometric, ultra-violet
Methods of general application Chromatographic, column Chromatographic, gas Chromatographic, spot detection Chromatographic, thin layer Color reactions Spectrophotometric, ultraviolet Miscellaneous Bile acids General, steroid hormones
(1119)
(92, 266, 338, 472, 808, 1162, 1327) (988, 1144) ( 1308)
Volumetric, acid-base Chromatographic, paper Microsublimation Optical properties Stabili tv Lipid extracts Chrom&ographic, column 19-Norsteroids Chromatographic, thin layer Chromatographic, .pa,per Sapogenins Chromatographic, thin layer Colorimetric Chromatographic, thin layer Steroid acids Bioassay Oxytocin Chromatographic, gas Pregnans Volumetric, acid-base Chromatographic, paper Progesterone
(791) (623) (807, 1058) (312) (623, 1058) (1058)
Steroids and Hormones (Continued)
Sterols
Chromatographic, partition Spectrophotometric, ultraviolet Chromatographic, gas Chromatographic, paper Chromatographic, thin layer
(90, 1060) (718) 118, 896) (103,
VOL. 37, NO. 5 , APRIL 1965
193 R
Table VIII. Compound or class Method or subject Benzothiadiazines Colorimetric
Phenothiazines
Sulfur-Containing Compounds
Reference
Spectrophotometric, ultraviolet Volumetric, ox-red. Volumetric, precipitation Chromatographic, gas Chromatographic, paper
/
Chromatographic, partition Chromatographic, thin layer (ZOk,346,969) Colorimetric (384,786) (878,273,580, Identification
762,1449) (147) (182,1211)
Review Spectrophotometric, ultraviolet Stability and degradation
Sulfonamides
(1.46.16L. 165. ' ish, 5i9, 973,998, 143% 1434) ( 1059)
Sustained release, tracer method Volumetric, acid-base Volumetric, coulometric Volumetric, ox.-red. Chromatographic, paper
(963,1187) (54) i36L.1136) (176;486, '709, 1000,1176) Chromatographic, thin layer (189,408,611, 630, 610,
1046) Colorimetric
(2% 56, 394,
Gravimetric Identification Polarographic Spectrophotometric, mass Spectrophotometric, ultraviolet Stability Volumetric. acid-base Volumetric; amperometric
.
'
771,773, 1214) (1011) (96,770,1019, 1067,1295) (925,926,927, 928) (1179) (455,825,830, 831,843, 1375) (1436) (1055.1206) ii409j Table IX.
Compound or class Oil-soluble Vitamin A
Method or subject Chromatographic, paper Chromatographic, partition ~. column Chromatographic, thin layer Colorimetric Colorimetric, automatic recording Polarographic Review Spectrophotometric Stability
Vitam+ A2 Vitamm A, 9-cis isomers Vitamin D
Compound or class
Reference
Sulfur (Miscellaneous) Cyclohexylsulfamates Disulfiram 2-Mercaptoimidazole Sodium camphorsulfonate Sodium lauryl sulfate Sodium noramidopyrine methanesulfonate Sulfinylpyridazines Sulfonylureas Sulfoxides Surface active agents Tetramethylthiuram disulfide Thioamides
Compound or class
(310)
1339) (1180,1235, 1247,1248)
Identification Gravimetric Volumetric, compleximetric Polarographic , Spectrophotometric, ultraviolet
(34)
Qtability Volumetric, coulometric Volumetric, ox.-red. Volumetric, precipitation Volumetric, ox.-red. Chromatographic, paper Volumetric, ox.-red. Chromatographic, paper Stability to ultrasound Colorimetric
(1016,1351) (1016) (1016,1350)
Method or subject Reference Chromatographic, adsorption (793,1216, column 1253,1396) Chromatographic, paper (143,789, Chromatographic, partition column Chromatographic, thin layer Colorimetric
(208)
Chromatographic
Reference ( 2 , 485) (62, 1305,
Vitamins
(1101,1256) (1018,1101)
Chromatographic, paper Spectrophotometric
Volumetric, precipitation
Colorimetric Identification Polarographic Spectrophotometric, ultraviolet Volumetric, acid-base Volumetric, ox.-red. Volumetric, precipitation Thiobarbituric Volumetric, ox.-red. acids Thiosemicarba- Colorimetric Volumetric, precipitation zones Review (methods) Thio-TEPA
(143,582, 1088,1060) (871,872)
(878,1250, 1316) ( 582) (489)
Method or subject Volumetric, compleximetric Volumetric, ox.-red.
Vitamin E
1050) (1216) (224,293) (793.1050.
Review, radiometric methods Spectrophotometric, infrared; differentiation of DI and DI Chromatographic, adsorption column Chromatographic, paper Chromatographic thin layer
(Continued
194 R
ANALYTICAL CHEMISTRY
Table IX. Compound or class
Vitamin K Water-soluble B1, Thiamine
Method or subject Colorimetric Optical activity, resolution of isomers Review Review, spectrophotometric Review, physicochemical Spectrophotometric Chromatographic, paper Chromatographic, thin layer Polarographic Chromatographic, adsorption column Chromatographic, complexometric Chromatographic, ion exchange paper Chromatographic, paper Colorimetric Fluorometric Fluorometric ; spectrophotometric Polarographic Review Spectrophotometric, UV St ability
Vitamins (Continued)
References
Compound or class
Electrophoretic, paper Identity 31icro-diffiision Radiometric Review
(730) (66) (661
(208,661) (143) (143) (207, 208,193)
Spectrophotometric Stability
( 1005)
(1297) (626, 653)
(1005, 2101, 1277) (937,1101, 1292) (780) (11, 462, 561,
HydrocobalSpectrophotometric amine Hydrpxycobal- Chromatographic, paper amine Chromatographic, thin layer Radiometric Spectrophotometric
C, ascorbic acid
Complexometric Identity Optical activity Polarographic Review Spectrophotometric, ultraviolet Stability
(1257) (1068) ( 803
(216)
( 653 )
(515, 653) (151, 1292) ( 635 ) (561 1
(181, 1101) (1101) (561, 1316) ( 1252) (181)
(1297) (525, 663) (305, 867) (914) (308, 779) (208, 780) (1315) (1257) (864,856) ( 1 , 81, 183 840, 864, 865, 867) ( $66 1
Reference (1, 183, 840,
864-5,857) (490) i6L5) (183, 867) ($17,H8, 8;i5) (276, 937, 1379) ( 7 7 , 80, 218, 252, 276. (80, 82,490, im, 1462, 1463) (77, 80) (218, 276,420,
796) ( 252
(97)
(218, 252, 276,
420, 7 9 6 ) (525, 6ii3,974) (153, 451, 911, 1260)
(252) (435, 818, 1163, 1215) (639) 11330)
(672)
(1101) (1101, 1254) (779, 911) (11, 245, 382.
451,458, 488,577,
(88)
~
Chromatographic, thin layer
Chromatographic, ion exchange paper Chromatographic, paper Chromatographic, thin layer Colorimetric
1316,1316, 1333,1419) Volumetric, complexometric Thiamine 35 S Chromatographic, electroDhoretic Thiamine, acyl- Chromatographic, paper; st ability Thiamine, N- Stability cyclohexylsulfamate Chromatographic, fluoroThiamine metric pyrophosChromatographic, ion phate exchange paper Chromatographic, ion BP,riboflavin exchange paper Chromatographic, paper Colorimetric Fluorometric, spectrohotometri c Poyarographic Review Stability Chromatographic, paper Riboflavin derivatives Polarographic Riboflavin, leucoChromatographic, complexoBe, pyridoxine metric Chromatographic, ion exchange paper Chromatographic, paper Chromatographic, thin layer Colorimetric Spectrophotometric Stability Volumetric, complexometric Chromatographic, ion BIZ,cyanocoexchange halamine Chromatographic, paper
l l e t h o d or subject Colorimetric
S'olumetric Folic acid Folic acid, tritiated Nicotinamide
Chromatographic, ion exchange paper Colorimetric Chromatographic, paper Chromatographic, gas Chromatographic, ion exchange paper Colorimetric Spectrophotometric, ultraviolet Stability T701umetric Colorimetric
Sicotinamide, cobalt chloride complex Nicotinic acid Chromatographic paper Pantothenic Chromatographic, coloriacid and salts metric Chromatographic, ion exchange Pant henol Chromatographic, ion exchange paper Fluorometric \-itamin P Chromatographic, paper suhst ances Chromatographic, spectrophotometric
$11 , ,934, 938, 1163, 1258, 1316, 1316, 1333) (383, 911,
1177) (625, 653)
( 1369)
(525, 663)
(458,1315) (208,309) (544)
VOL. 37, NO. 5 , APRIL 1965
195 f?
Table X. Compound or Class
Formulations, Mixtures, and General Methods
Method or subject
Reference
Compound or Class
Chromatographic, gas Chromatographic, paper Chromatographic, gas Voliimetric, ox.-red. Chromatographic, gas Chromatographic, ion exchange Chromatographic, thin layer Colorimetric Volumetric, acid-base Volumetric, complexometric T-oliimetric, high frequency Amines, high boil- Chromatographic, gas ing Amines, Volumetric, complexometric (978) quaternary Antacids Xeutralization rate (89, 816, 908, 909, 910) Review (1106) Chromatographic, gas Antipyretics ( 800 1 Complexometric (314) Identity 11066) Antituberculins Volumetric, ox.-red. (753)' Analgesics (1557) Chromatographic, paper Chromatographic, thin (259, 407) - layer Compatibility Comdexometric Idenhty Volumetric, acid-base Chromatographic, gas Anesthetics
Acids Alcohols Aldehydes Amides Amines
Anesthetics, local
.4ntibiotics Antihistamines
Antiseptics Antit ussives Azulenes Barbiturates
Chlorinated hydrocarbons Dyes
Emodins Esters N-Ethyl groups Ethylene groups General techniques
Spectrophotometric, infrared Chromatographic, paper Chromatographic, thin layer Review Volumetric, acid-base Identity Chromatographic, paper
Chromatographic, ion exchange Chromatographic, paper Chromatographic, - . thin layer Spectrophotometric, infrared Volumetric, acid-base Spectrophotometric, infrared Chromatographic, column Chromatographic, paper Chromatographic, thin layer Identity Colorimetric Chromatographic, gas Identity Identity Chromatographic, gas Chromatographic, paper Chromatographic, thin layer
196 R
ANALYTICAL CHEMISTRY
Phase solubility Polarographic Purity tests Refract ometri c Review, ultraviolet Spectrophotometric, ultraviolet Stability, effect of trace copper Stability, effect of heavy metals Thermal analysis Turbidimetric Volumetric, acid-base
Hypnotics Ketones Monamine oxidase inhibitors Xarcoti cs Phenothiazint?S
Sedatives Steroids
Chromatographic, partition column Chromatographic, thin layer Stability Chromatographic, partition column Colorimetric; paper chromat ography Chromatographic, gas
Sulfonamides
Sympathomimetics Tranquilizers (1047) (1047, 1268) (477)
Method or sitbject Colorimetric Complexometric Countercurrent distribution Dissolution rate Electrophoretic Isotope dilution hielting point
A. General methods
Vaccines, adsorbed Xanthines
X-Ray Zone melting Chromatographic, thin layer Chromatographic, gas Identity Chromatographic, gas Chromatographic, paper Chromatographic, gas Chromatographic, paper Chromatographic, thin layer Identity Chromatographic, paper Chromatographic, thin layer Chromatographic, thin layer Chromatographic, paper Spectrophotometric, infrared Chromatographic, paper Chromatographic, thin layer Fluorometric Spectrophotometric, infrared Volnmetric. ox.-red. Chromatographic, gas Countercurrent distribution Chromatographic, gas Chromatographic,, paper Spectrophotometric Catalytic
(660) (967, 959) (1369) (1261) (1425)
Chromatographic, paper
(707)
B. Formulations, mixtures and miscellaneous Compound or formulation Acetone Acetazolamide Acetonitrile Acetylsalicylic acid
Method or subject Volumetric, ox.-red. Polarographic I'se as solvent Chromatographic, gas Chromatographic, ion exchange paper (398, 1237) Chromatographic paper Chromatographic, thin (379) layer Compatibility Identity Xuclear magnetic resonance Refractometric Volumetric, acid-base
(Continued)
~~
Table X. Compound or formulation
Formulations, Mixtures, and General Methods (Continued) Compound or formulation
Method or subject
Chromatographic, thin layer Countercurrent distribution Chromatographic, paper Chromatographic, thin layer Extractive; miscellaneous Identity Miscellaneous Refractometric I'olumetric, acid-base TTolumetric, complexometric Volumetric, high frequency p - Aminobenzoic Volumetric; complexometric acid esters p-Aminosalicyl- Coulometric ate, sodium Amobarbital Refractometric Amylsil Volumetric, acid-base Aniline Refractometric Volumetric; complexometric Extractive; miscellaneous Antipyrine Identity Aliscellaneous Refractometric Volumetric; miscellaneous Volumetric, acid-base Aritrenyl Volumetric, acid-base Aprophen Chromatographic, thin Aucubin lnvpr
Identity Refractometric Barbital, sodium Extractive; paper chromatographic Barbamyl Colorimetric Benzacine Volumetric, acid-base Belladonna ex- Extractive; miscellaneous tract 2-Benzyl-2-imid- Volumetric, acid-base azoline hydrochloride Chromatographic, paper Benzoate, sodium Volumetric, high frequency Benzyl mandel- Chromatographic, thin layer ate Bismuth subExtractive; miscellaneous gallate Boric acid Refractometric Bromcamphor Refractometric Bromisoval Refractometric Butobarbitone Chromatographic, partition column Caffeine Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper Chromatographic, thin layer Coulometric Extractive; miscellaneous Miscellaneous Nuclear magnetic resonance Refractometric Volumetric, acid-base Volumetric, high frequency Calcium bromide Bda-ray Camphor Refractometric Cannabis Identity Cetran Spectrophotometric, ultraviolet ChloramphenIdentity icol Miscellaneous Chlorguanide Identity Chlorhexidine Colorimetric Chloroform Chromatographic, gas Chlorothiazide Polarographic
Method or subject
ChlorphenirChromatographic, partition amine column Chlorpromazine Gravimetric Identity Miscellaneous Colorimetric ChlortetraVolumetric, complexometric c cline Chromatographic, paper CoJeine ion exchange Chromatographic, thin layer Extractive; miscellaneous Refractometric Volumetric, high frequency Cymarine Chromatographic, thin layer Dehydrochloric Identity acid Demorphan Volumetric, acid-base Dibucaine Volumetric, acid-base Dichloroethane Use as extractive Diethazine Identity Volumetric, acid-base Diphylline Extractive; gravimetric Dipyrone Volumetric; complexometric Dormutil Chromatographic, paper Ephedrine Extractive; miscellaneous
S-ilcetylsulfanilamide Adrenaline Aminopyrine
Ethylaminobenzoate
Colorimetric
Ethylmorphine
Extractive; miscellaneous Identity Colorimetric Extractive; miscellaneous Spectrographic, ultraviolet
Estradiol benzoate Ethionamide Ferric chloride
(651) (433) ( 403)
(172, 173) (1243) (1042) (1042) (1412) (499) (403, 1047, 1448) (561, 1213, 1567) (126, 379, 403, 1047) ( 696 )
(173, 984) (1269) (606)
(918) (673,1022, 1023)
Extractive; gravimetric Complexometric Refractometric Ferrous iron Complexometric Ferrous sulfate Miscellaneous Gentisic acid Spectrophotometric, ultraviolet Glucose Extractive ; miscellaneous Refractometric Glycerol Miscellaneous Refractometric Halothane Spectrophotometric, infrared Hemp, Indian Miscellaneous Hexamet hylene- hliscellaneous tetramine Refractometric Hexobarbital Identity Homatropine Miscellaneous 1-Hydrazino Colorimetric phthalazine Hydrochloric Refractometric acid Hydrocortisone Spectrophotometric, ultraacetate violet 8-HydroxyIdentity quinoline sulfate Hydroxyzine Coulometric Infusions Chromatographic, adsorption column Injectables Stability Isoniazid Coulometric Isonicptinic Refractometric acid Kanamycin Volumetric, ox.-red. Lemoran Volumetric, acid-base Magnesium Miscellaneous sulfate Meperidine Spectrophotometric, ultrahydrochloride violet Meprobamate hliscellaneous hlethadone Extractive; paper chrohydrochloride matography
VOL. 37, NO. 5 , APRIL 1965
197 R
To ble X. Compound or forniulat ion
Formulations, Mixtures, and General Methods (Continued)
Method or subject
Extractive; paper chroJlethapyrilene hydrochloride matographic Spectrophotometric, ultraviolet JIethylphenoChromatographic, partition barbitone column Jlorphine Chromatographic, thin layer hydrochloride Extractive, paper chromatographic Identity Xicotinic acid Nitrofurantoin Polarographic Xorcaine Gravimetric; Volumetric Chromatographic, ion Papaverine hydrochloexchange, thin layer Extractive, miscellaneous ride ~~
Reference (298)
pentobarbital calcium Perparine Phenacetin
Pheniramine Phenobarbital
Volumetric, acid-base Volumetric, complexometric Spectrophotometric, ultraviolet Volumetric; complexometric
Progesterone
(1412)
Pyridine derivatives Pyrimethamine Volumetric, acid-base Pyruvate isoni- Hydration, crystallinity azone calcium Quinidine Chromatographic, thin - . layer Quinine Chromatographic, thin layer Quinocide Volumetric, acid-base Saffron adulter- Chromatographic, paper ations Salicylic acid Compatibility Spectrophotometric, ultraviolet Salicylate, Miscellaneous sodium Volumetric, high frequency Santonin Identity Sodium chloride Refractometric Beta-ray
( 379 1
(298)
Chromatographic, paper Spectrophotometric, ultraviolet Hydration, crystallinity
Reference (662)
(2297) (780) (1681) (367) (1320)
(373) (379) (357) (831) (463) (983) (551, 1269) (433)
( 900 1
(1343)
( 1368)
So:EOL-
Xiscellaneous Chromatographic, gas Chromatographic, ion exchange Chromatographic, paper Chromatographic, paper ion exchange Chromatographic, thin layer Extractive; miscellaneous Identity Chromatographic, partition column Chromatographic, paper Chrqmatographic, partition column Chromatographic, thin laver Cdl&Imetric Extractive; miscellaneous Identity Miscellaneous Refractometric Spectrophotometric, ultraviolet Volumetric, acid-base Extractive; miscellaneous ~~
Phenobarbital sodium Phenylpropanol- Chromatographic, partition column amine Phenylsalicylate Spectrophotometric, ultraviolet Refractometric Chromatographic, partition Phenytoin column Countercurrent distribution Pholedrine Colorimetric Phthalazol Potassium bro- Extractive; miscellaneous Refractometric mide Extractive; miscellaneous Potassium Refractometric iodide Miscellaneous Preludin Chromatographic, thin Procaine layer Refractometric
198 R
Method or subject
(361)
Gravimetric; volumetric Nuclear magnetic resonanc:e Volumetric, acid-base Pentinol Pentobarbital
Compound or formulation
ANALYTICAL CHEMISTRY
( 792 ) (499) (1047)
(1237) (1215)
(126, 379) (175, 984) (900) (738) (1237) (1412) (126) (756) (107, 173)
(196)'
'
(876, 1347) ( 17.2)
zoate Sodium thioBeta-ray sulfate K-Strophanthin- Chromatographic, thin B layer K-Strophantho- Chromatographic, thin side layer Strychnine Extractive: chromatographic ' hydrochloride Succinyl sulfaMiscellaneous thiazole Sulfadiamine Colorimetric Sulfamethazine Identity Miscellaneous Identity Sulfamethylthiazole Sulfanilamide Chromatographic, thin layer Chromatographic, thin Sulfapyridine layer Sulfathiazole Chromatographic, thin layer Identity Miscellaneous Sulfathiourea Identity Suppository Miscellaneous mixtures Tetracaine hy- Volumetric, acid-base drochloride Tetracycline Colorimetric Terpin hydrate Refractometric Coulometric Theobromine I'olumetric, acid-base TetrahydroRefractometric zoline Volumetric, acid-base Theophylline Chromatographic, ion exchange Coulometric Extractive; miscellaneous Volumetric, acid-base Tofranil Miscellaneous . Urotropine Volumetric, high frequency Vincamine Polarographic Water in drugs Dielectric Hygroscopicity Radiometric Zinc chloride Refractometric
( 1368)
(379) (379) (298)
(379) (373) (373) (300)
(107) (900)
(105, 107)
( 662 1 ( 665 1
(1042) (551, 596) (875, 1023) (1243) (1022) (1448) ( 5% 1 ( 172, 173) ( 1023)
(216) (433) ( 322 1 (388, 1127) (711 (6.28)
134%
A review of methods of identification of 47 narcotic drugs is available ( 8 7 4 ) . A comprehenPive survey of the use of EDTA in drug analysis has been made (163). Indicators, buffers, masking and demasking techniques, and applications are discussed. Recent developments in pharmaceutical analysis have been discussed (986) and the analytical chemistry of pharmaceuticals, antibiotics, and surfactants presented ( 5 7 4 ) . The use of tritiumlabeled compounds in pharmaceutical research was reviewed by Snell (1165). Beckett and Stenlake have published a book on the quantitative analytical aspects of pharmaceutical chemistry ( 8 7 ) . Ashworth has compiled a n exhaustive bibliography on titrimetric methods for organic iconipounds (39). The subject material is arranged by compound class and also according to the titrant used. M a n y references to pharmaceutical products are included. Papers presented a t the 1961 Symposium on Titrimetric Methods have been published in book form (565). Several papers are devoted to topics of pharmaceutical interest. .I section on the basicity of a large number of excipients used in pharmaceutical formulations is included. By choosing the proper solvent for the titration of a formulation, excipient interference may be minimized or eliminated entirely in some instances. LITERATURE CITED
( 1 ) Abd El Raheem, -4.A , , Dikhana, M. .\I., 2. Anal. Chem. 189, 389-96 (1962); ('A. 58, 3879b (1963). ( 2 ) Abdine, H., Abdel Sayed, W. S., J . Pharm. Pharmacol. 14, 761-3 (1962); C.A. 58, 437% (1963). ( 3 ) Adachi, T., Bifamin 27, 433-7 (1963); C . A . 60, 2723b (1964). ( 4 ) fbid., pp. 438-41 (1963). ( 5 ) Adamanis, F., Kucharski, S., Poznan. Towarz. Przyjaciol S a u k , Wydzial Lekar., Prace Komisji Farm. 2, X o . 2, 89-91 (1962); C . A . 59, 1440s (1963). (6) Ibid., pp. 93-7 (1962). ( 7 ) Adamanis, F., Pawelczyk, E., Plotkowiakowa, Z., Farm. Polska 18, 180-3 (1962); C . A . 58, 438lf (1963). (8) Ibid., pp. 513-51 (1962); C . A . 59, 3718h (1963). ( 9 ) Adamanis, F., Pawelczyk, E., Plotkowiakowa, Z., Poznan. Towarz. Przyjaciol .\'auk., Wydzial Lekar., Prace Komisji Farm. 1, S o . 3, 3-11 (1962); P . A . 59, 37218 (1963). ( I O ) I b i d , , pp. 13-22 (1962); C . d . 59, 286% (1963). (11) Agrawal, 11. K., Sen, R., ITprety, .\I. C., Sen, S . , LIohan Rao, T. K., Indian J . Technol. 1, So. 2, 90-3 (1063): C.A-l.58, 1 2 3 7 3 ~(1963). (12) Agrawal, K. C., Dutta, B. X . , Indian ,I. r l p p l . Chem. 24, 186--92(1961): C.A. 58, 4377f (1963). (13) Agrawal, K. C.. I h t t a , B. N., J . t'roc. Inst. Chemists ( I n d i a ) 34, 73-9 57, 12635f (1962). (1962); (>.&I. (14) Akerstrom, S., Lindahl, P.E.B., .-lcta Chem. Scand., 16 ( 5 ) , 1206-121, (1962); .hd.:16str. 10, 335 (1963). ( I , ? ) Akita, E., Ikekawa, T., J . Chromatog. 12, ( 2 ) , 250-1 (1963); C.A. 60, :36Xd (1964).
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~~
~
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(464) Gyenes, I., Bayer, J., Pharmazie 16, 211-17 (1961); C.A. 57, 47619 (1962). (465) Halmekoski, Jaakko, Suomen Kemistilehti B35, 209-12 (1962); C.A. 58, 7789h (1963). (466) Halmekoski, Jaakko, Ibid., B36, 40-2 (1963): C.A. 59. 384b 11963). (467) Ibid., pp. 58-60;’ C.A.‘ 59, 2589h \----,-
(\ -196.1). - - - I
(468) Halmekoski, Jaakko, Hannikainen, Helka, Ibid., 35B, 221-4 (1962); C.A. 58, 7350a (1963). (469) Halot, D., A n n . Pharm. Franc. 19 (7-8), 477-482 (1961); Anal. Abstr. 9, 2900 (1962). (470) Halot, D., A n n . Pharm. Franc. 19 (7-8), 483-493 (1961); Anal. Abstr. 9, 2906 (1962). (471) Haniilton-1Lliller, J . >I. T., Smith, J. T., Knox, R., J . Pharm. Pharmacol. 25 ( 2 ) . 81-91 -~ -~ (1963). (472) Ham, Shoji,. Kugaku N o Ryoiki 17, 196-206 (1963); C.A. 60, 7d (1964). (473) Harting, H. L., Pharm. Ind. 25, 57-9 (1963): C.A. 58. 13722b (1963). (474) Hattori,’ Tetsuyasu, Nishiumi, Michinori, Arch. Prac. Pharm., Japan, 21 ( l ) , 9-14 (1961); Anal. Abstr. 10, 3876 (1963). (475) Haug, U., Panescu, I., Pharmazie 18 ( 5 ) , 340-1 (1963); C.A. 60, 3 7 2 ~ ( 1964). (476) Hauton, J. C., J . Chromatog. 7, 341-5 (1962). (477) Hayden, A. L., J . Pharm. Sci. 51. 617-22 (19621. (478); Hayden; A. L., Sammul, 0. R., Selzer, G. B., Carol, J., J . Bssoc. Ofic. Agr. Chemists 45, 797-900 (1962). (479) Hayes, J. R., Jr., I h B u y , H. G., ilnal. Biochem. 7 131, 322-7 (1964). (480) Head, W. F., Jr., J . Pharm. Sci. 50 (12), 1041-1044 (1961). (481) Healton. D. C.. J . Assoc. Offc. Agr. Chemists 45, 616-20 (1962). (482) Healton, D. C., Ibid., 46, 652-4 (1963). (483) Hedner, P., Acta Pharm. Tox., Kbh. 18 (4), 407-413 (1961); Anal. Abstr. 9 , 3399 (1962). (484) Hefferren, J. J., Klessig, R. S., Dietz, C. L., J . Dental Res. 42, 793-802 (1963). (485) Hennart, C., Chim. Anal. 44 (11, 8-11 (1962); Anal. Abstr. 9 , 3423 (1962). (486) Hentrich, K., Pharmazie 18, 405-9 (1963); C..4. 60, 373d (1964). (487) Hernandez, R., Jr., Axelrod, L. R., ANAL. CHEM. 35 ( l ) , 80-83 (1963). (488) Herrmann, J., Grossmann, H. G., Pharm. Zentralhalle 101, 743-8 (1962); C..4. 59, 1442f (1963). (489) Herting, I). C., Ilrury, E. J. E., Harris, P. L., 4nal. Biochem. 4 (6), 459-475 (1962). (490) Herxmann, H., Hennig, A., Z . Naturforsch. 17b, 646-54 (1962); C . A . 58, 1307c (1963). (491) Hetman, J. S., Lab. Pracf. 12 (81, 727-8, 740 (1963). 1492) Himchi. Takeru, Proc. A m . Assoc. ‘ Coll. Fharm. Teachers’ Seminar 13, 119-24 (1961). (493) Higuchi, W. I., Lau, P. K., Higuchi, T., Shell, J. W., J . Pharm. Sci. 52, 150-3 (1963). (4941 Himchi. W. I., Rowe, E. L., ‘ Hiestaid, E, N., I b i d . , 52, 162-4 (1963); C.A. 58, 11168e (1963). (495) Hiller, K., Pharmazie 16, 600-603 (1961); .Anal. Abstr. 10, 1152 (163). (496) Hillers, S., Egerts, V., Simanska, A l . , ilkad. ;Vhuk. Latu. SSR Inst. Organ. Sinteza 1962, 17-27; C . A . 59, 3719b (1963). (497) Hishta, Charles, Reschke, R. F., % - , I
~
204 R
ANALYTICAL CHEMISTRY
Microchem. J . Symp. Ser. 2, 679-86 (1Y62); C.A. 58, 885lh (1963). (498) Hoerhammer, L., Wagner, H., Koenig, H., Deut. Apotheker-Ztg. 103 (17), 502-4 (1963); C.A. 59, 12593f (1963). (499) Hoffman, A. J., hLlitchel1, H. I., J . Pharm. Sci. 52, 305-6 (1963). (500) Hofstetter, R., Muhlemann, H., Pharm. Acta Helv. 38, 218-23 (1963); C.A. 59, 2591a (1963). (501) Ibid., pp. 349-57 (1963); C.A. 59, 11190e (1963). (502) Hoft, E., Schultze, H., J . Prakt. Chem. 19 15-6). 260-265 (1963): Anal. Ab&. 1 1 , ‘1319’(1964): (503) Hoil, W. W., llichaels, T. P., Sinotte, L. P., J . Pharm. Sci. 52, 817-18 (1863). (504) Holbrook, A., Bailey, F., Bailey, G. 32.. J . Pharm. Pharmacol. Suvvl. 15. 274-7’11963). (505) Holbrook, A., Barlow, F. S., Bailey, F., Ibid., 15, 232-5 (1963). (506) Hollis, I). P., ANAL.CHEM.35 ( l l ) , 1682-4 (1963). (507) Hollos, J., Gyogyszereszet 7 (5-6), 204-10 (1963); C.A. 60, 15409 (1964). (508) Homan, J. L). H., Med. Prom. SSSR 16, NO.4, 20-7 (1962); C.A. 57, 8659h (1962). (509) Horak, F., Chem. Zvest. 17, 795-7 (1963); C.4. 60, 9099d (1964). 1510) Horak. P.. Holoubek. J.. Burnba. T’. Cekan, Z.,‘ Coll. Czech. Chem. Commun. 27, 1037-42 (1962); C.A. 58, 10038f \
-
I
,
1 .
(1963) ~-;_I,.
(511) Horvath, D., Magy. Kem. Folyoirat 68. NO. 7, 324-5 11962); C.=l. 57, 15i43a (1962). (512) Hossein, A . M., Kassim, Aly, Hamad, Hassan, A. .4., Egypt. Pharm. Bull. 42, NO. 4, 395-409 (1960); C..4. 58, 438O.f (1963). (513) Houk, A. E. H., J . Pharm. Sci. 52, 738-43 (1963). (514) Ibid., pp. 743-7. (515) Hoyem, T., J . Assoc. O$c. Agr. Chemists 45, 902-905 (1962). (516) Hrdy, O., Ceskosl. Farm. 11, 192-6 (1962); Anal. Abstr. 9, 4858 (1962). (517) Ibid., pp. 255-259; Anal. Abstr. 9, 5402 (1962). (518) Hrdy, O., Kolcova, J., Ceskosl. Farm. 1 1 (4), 185-187 (1962); Anal. Abstr. 9, 4858 (1962). (519) Huang, C. L., Sands, F. L., J . ChTOmatOg. 13 ( I ) , 246-9 (1964). (520) Huang, C.-S., Wang, H., Wang, L.-L., Yao Hsueh Hsueh Pao 10 (61, 372-5 (1963); C.A. 59, 13768h (1963). (521) Hurst, L. S., “Titrimetric hlethods,” Proc. Symp. Cornwall, Ont., Can. 1961, 179-85. (522) Huttenrauch, R., Pharm. Zentralh. 102 (4), 203-208 (1963); Anal. Abstr. 1 1 , 1452 (1964). (523) Huttenrauch, R., Z . Physiol. Chem. 326, 166-167 (1961); Anal. Abstr. 9 , 5379 (1962). (524) Huttenrauch, R., Keiner, J., Pharm. Zentralhalle 102 ( l o ) , 615-17 (1963); C.A. 60, 78745 (1964). ( 5 2 5 ) Huttenrauch, R., Klotz, L., Experientia 19 (2), 95-96 (1963); Anal. ilbstr. 10, 5408 (1963). (526) Huttenrauch, R., Resch, IT., Arch. Pharm. Berlin 295 (4), 256-260 (1962); Anal. Abstr. 9 , 4428 (1962). (327) Ibadov, A. Yu., Gafurov, Sh., Dokl. Akad. Nauk U z . SSR 1961, No. 9, 31-3: C.A. 58, 12368h (1963). (528) Ichibangase, H., Kojima, S., J . Pharm. Soc. Japan 82 (12), 1616-1620 (1962); Anal. Abstr. 10, 5391 (1963). (529) Ichimura, Y., Runseki Kagaku 8, 557-61(1959); C.A. 58, 10041b (1963). (530) Ichimura, Y., Ibid., 10 (6), 623-625 (1961); Anal. Abstr. 10, 3414 (1963).
(531) Ichimura, Y., Nishimoto, K., Ibid., 1 1 , 1024-7 (1962); C . A . 57, 16748d (1962). (532) Iconomou, S., Buechi, J., Schumacher, H., Pharm. Acta Helv. 38, 175-88 (1963); C . A . 59, 2593b (1963). (533) Iconomou, K., Buechi, J., Schumacher, H., Ibid., 38, 275-92 (1963); C.A. 59, 9736f (1963). (534) Icononiou-Petrovitch, N., Buechi, J., Ychuniacher, H., Ibid., 37 (9-10), 622-638 (1962); C.A. 58, 43789 (1963). (535) Zbid., 37, pp. 638-710: ilnal. Abstr. 10. 3718 (1963’1. (536)’ Ibid.,‘ 37,-’pp. 748-69; C . A . 58, 7784b (1963). (537) Ibid:, 38 ( l ) , 26-33 (1962); Anal. Abstr. 10, 4872 (1963). (538) Ibid.. 38 (2). 102-118 (1963): Anal. Abstr. 11’. 319 (19641. (539) Igloy; M , , Magy. ~ Kem. Lapja 18 (12), 622-4 (1963); C.A. 60, 10476d (1964). (540) Iguchi, S., Yamamoto, 31., hoyama, T., Yakugaku Zasshi 83, 721-3 (1963); C.A. 59, 12595, (1963). (541) Ikeda, D., Yu, T., Bitamin 21, 230-6 (1960); C.A. 60, 3954e(1964). (542) Ikekawa, T., Iwami, F., Akita, E., and Umezawa, H., Penishirin Sono Ta Koseibusshitsu Ser. A 16 ( l ) , 56-7 (1963); C.il. 60, l539c (1964). (543) Ikram, 12.,Bakhsh, AI. K., ANAL. CHEM.36 ( l ) , 111-12 (1964). (544) Ikraniov, L. T., Vopr. Ispol’z. Mineral’n i Rust. Syr’ya. Sredn. Azii (Tashkent. Akad. ‘Vauk C’z. S S R ) Sb. 1961, 160-3; C.A. 58, 10040h (1963). (545) Ikramov, L. T., Aliev, Kh., Aptechn. Delo 1 1 ( 5 ) , 68-9 (1962); C . A . 60, 10478b (1964). (546) Iliev, AI.) Farmatsiya (Sofia) 12, NO. 1, 27-9 (1962); C.A. 58, 8 8 5 2 ~ (1963). (547) Illig, X., Buechner, AI., Acta Biol. .%fed. Ger. 1 1 . 6-13 (1963): C . A . 60, 154la (1964). (548) Ilver, K., Jackerott, .4a., Dansk. Tidsskr. Farm. 37 (6), 129-40 (1963); C.A. 59, 11190g (1963). (549) Ibid., pp. 225-36; C.A. 60, 395ld (1964). (550) Inczedv. J.. Gimesi. 0.. Acta Chim. Acak’ Sci.’Hung. 31’(4), 347-356 (1962); C.A. 58, 933f (1963). (551) Inoue, T., Hoshi Yakka Daigaku Kiuo 10, 17-19 (1961); C.A. 57, 959d (1962). (552) Invernizzi, I., Sampietro, C., Boll. Lab. Chim. Provinciali 14 (2), 127-134 (1963); ilnal. Abstr. 1 1 , 1923 (1964). (553) Ioffe, I . S., Sukhomlinov, F. K., Leproskii, A. N., Bukhman, L. B., Zh. Prikl. Khim. 36, 629-32 (1963); C . A . 59, 2,596b (1963). (554) Iritani. N.. Arizono. K.. Yakuaaka ‘ Zusshi 83; 1083-6 (1963); C.A.” 60, ~
9.-.__ i n 2 h (19134). \ - - - - I
( 5 5 5 ) Iritani, S . , Suzuki, N., Ibid., 82; 1073-6 (1962); C.A. 57, 1 5 2 4 2 ~(1962). (556) Iritani, K., Suzki, It.,J . Pharnz SOC.Japan83, ( l ) ,98-IOO(1963); Anal. Abstr. 1 1 , 336 (1964). (557) Irmscher, H., Pharm. Prazis, Beilage Pharmazie 1961, 184; C . A . 57, 13889c (1962). ( 5 5 8 ) Irudayasarny, A., Natarajan, A. R., Analyst 87, 831-832 (1962). (559) Isarenko, N. Ya., Orlov, Yu. E., Shraiber, M. S., Med. Prom. SSSR 17 (9), 38-40 (1963); C.A. 60, 2721d (1964). (560) Iso, T., J . Biochem. (Tokyo) 51, 345-49 (1962); C.A. 57, 11471a(1962). (561) Ivanov, N . P., Il’ich, G. K., Lab. Delo 8, No. 2, 24-7 (1962); C.A. 57, 4195d (1962). (562) Ivashkiv, E., J . Pharm. Sci. 51, 698-9 (1962).
(563) Izawa, Y., Kimura, W., J . Japan Oil Chem. SOC.1 1 (12), 627-630 (1962), -4nal. Abstr. 10. 4256 (1963). (564) Izniailov, 3 . A,, hlushinskaya S. Kh., Danel’yants, \-. -4.,Med. Prom. S S S R 17 ( 7 ) , 47-50 (1963); C..4. 59, 1 2 5 9 4 ~(1963). (565) Jackson. 1). S.. “Titrimetric Methods,” Proc. of 1961 Symposium on Titrimetric Methods, Cornwall, Ontario, M a y 8-9, 1961, Plenum Press, New York, 1961, 185 pp. (566) Jackwerth, E., Arch. Pharm., Berlin 295 ( l o ) , 779-795 (1962); C . A . 58, 4376d (1863). (567) Jakovljevic, I. )I., ANAL. CHEM. 35 ( l o ) , 1513-16 (1963). (568) Jakovljevic, I. AI,, Fose, J. ?*I., Kuzel, N. R., ANAL.CHEM.34, 410-413 (1962). (569) Jancik, F., Korbl, J., Ceskosl. Farm. 1 1 (6), 305-308 (1962); Anal. dbstr. 10, 336 (1963). (570) Jancik, F., Koerbl, J., Sulovsky, J., Czech. 108,813, Nov. 15, 1963, Appl. Xov. 29, 1962; C..4. 60, 10482c (1964). (571) Jayaraman, K . S., Ramanujam, S., Vijayaraghavan, P. K., Curr. Sci. 31 ( 7 ) , 282-283 (1962); Anal. Abstr. 10, 3455 (1963). ( 5 7 2 ) Jindra, L., Hejlek, J., Janat, Y., Farm. Obzor 32 ( l ) ,6-11 (1963); C . A . 60, 375e (1964). ( 5 7 3 ) Johannesen, B., Sandal, A., Medd. ,Vorsk Farm. Selskap 23, 105-13 (1961); C.A. 57, 152385 (1962). (-574) Johnson, C. A,, Mfg. Chemist 34 ( l o ) , 480-2, 489 (1963). ( 5 7 5 ) Johnson, C. A , , King, R. E., J . Pharm. Pharmacol. Suppl. 14, 77-82 (1962). 1576) Johnson, C. A,, King, R. E., Ibid., 15 (9), 584-8 (1963). ( 5 7 7 ) Jonaitis, H., Rubikaite, B., Lietuvos Fiz. Rinkinys, L i e t w o s T S R Mokslu Akad., Leituvos T S R dukstosios Mokyklos 1 , KO. 1-2, 207-16 (1961); C . A . 58, 8857e (1963). (*578)Jones, R . , Page, B. C., ANAL. CHEW36 ( l ) , 35-8 (1964). (579) Jones, W., Pharnl. J . 191, No. 5218, 459-62 (1963). ( 5 8 0 ) J . Pharm. Sci. 53 ( l ) ,101-3 (1964). (581) Jue, J., Huyck, C. L., J . Pharm. Sri. 51. 773-6 (1962); C . A . 57, 1263.7” (1962).’ (382) Jungalwala, F. B., Cama, H. R., J . Chromatog. 8 , 535-536 (1962). (-583) Jungnickel, H. E., Klinger, W., Pharmazie 18, 353-5 (19631, C..4. 59, 15120e (1963): (584) Jusiak, L., Soczewinski, E., Waksmundzki, A., Acta Polon. Pharm. 19, 193-8 (1962); C.A. 59, 382e (1963). (585) Kadar-Pauncz, J., Acta Chim. A c a d . Sci. Hung. 35 (3), 297--299 (1963); Anal. Abstr. 10, 2876 (1963). (586) Kadis, B., Harris, C., Salhanick, H. A,, J . Chromatog. 7, 430-431 (1962). (587) Kakac, B., Ceskosl. Farm. 12 (4), 177-182 (1963); Anal. Abstr. 1 1 , 1902 (1964). (588) Kakac, B., Hudlicky, AI., Talanta 9 (6), 530-533 (1962). (589) Kakemi, K., Arita, T., Ohashi, S., J . Pharm. SOC.Japan 81 ( 5 ) , 748750 (1961); Anal. Abstr. 9 , 4896 (1962). (590) Kakemi, K., Ohashi, S., Yakuqaku Zasshi 82, 338-42 (1962); C . A . 57, 11310f (1962). (591) Kakemi, K., Arita, T., Sezaki, H., Kadai, T., Ibid., 82, 297-9 (1962); C . A . 58, 32706 (1963). (592) Kakemi, K.. Yokata, T., Nadai, T., Ibid., 80 ( 2 ) , 176-180 (1960); Anal. Abstr. 9 , 4459 (1962). (-593) Ibid., pp. 180-183.
(594) Kala, H., PrLarmazie 16, 297-305 (1961); ,.Anal. Abstr. 10, 1173 (1963). (595) Kalinowska. Z. E.. Acta Polon. Pharm. 20 ( l ) , 69-75 (1963); Anal. Abstr. 10, 4877 (1863). (596) Ibid., pp. 193-198: Anal. Abstr. 11, 741 (1964). (597) Kalinowhka. Z.., E.., Bartnik-Kurzawinska, J., Ibid., 19, 45-53 (1962); C . A . 57, 47653 (1962). (598) Kalinowska, Z. E., Kochalska, J., Ibid., 20, 59-67 (1963); .lnal. Abstr. 10,4879 (1963). (599) Kalinowska, Z. E., Podkowska, L., Alieszczakowska, J., Farm. Polska 196(15-16), 329-31 (1963); C.A. 60, 104789 (1964). (600) Kalinowski, K., Baran, H., Acta Polon. Pharm. 16, 231-3 (1959); C.A. 58, 8852a (196.3). (601) Kalinowski, K., Fecko, J., I b i d . , 20, 53-58 (1963); -4nal. .-lbstr. 10, 4367 (1963). (602) Kalinowski, K., Piotrowska, A., Ihid.. 2 0 (2i. 199-204 119631: .Anal. ~. Abst;. 1 1 , i46 (1964). (603) Kalinowski, K., Zwierzchowski, Z., I b i d . , 20, 303-308 (1963); Anal. Abstr. 11, 1471’(1964). (604) Ibid.. DD. 309-313: Anal. Abstr. 1 1 , 1470 (fg64). (605) Kamp, W., Klijsen, J. B., Ruward, R. H., Pharm. Weekbl. 97 ( 2 5 ) , 889-894 (1962), Anal. Abstr. 10, 3868 (1963). (606) Kaneko, H., Fujimoto, R., Namba, K., Hayashi, K., J . Pharm. Soc. Japan 82, 1493-1496 (1962); Anal. Abstr. 10, 5357 11963). (607) Idid., pp. 1489-1492; Anal. Abstr. 10, 5357 (1963). (608) Kao, Tzu-I, T’ien, Ping-Shih, Hua Hsueh Hsueh Pao 27 ( 3 ) , 167-72 (1961); C.A. 59, 125949 (1963). 1609) KaDadia. G. J.. Roa. G. S.. J . Pharm.’Sci. 53 ( 2 ) , 223-4 (1964). (610) Karawya, 11. S.,El-Deeb, S. R., Egypt. Pharm. Bull. 42, KO. 4, 107-16 (1960): C . A . 57, 16752f (1962). (611) Karpitschka, N., Mikrochim. Ichnoanal. Acta 1963,157-64: C . A . 58,10042d (1963). (612) Kartnig, T., Pharm. Zentralhalle 98, 495-9 (1959); C.iZ: 59, 259lb j
, /
~
(lQ62\. \ - - - - ,
(613) Kas, I.., Prakt. Lekar43, ( 3 ) 112-14 (1963), C . A . 59, 1439e (1963). (614) Kashima. T.. Watari, T., Mikubo, ‘ H., Eisei Shikensho Hokok 79, 59-63 (1961): C.A. 59, 1438c (1963). (615) Kassau, E,, Deut. Apotheker Ztg. 100 (38), 1102-6 (1960); C . A . 60, lii42a (1964). (616) Kato, K . , Sato, K., Tsuda, T., Yakuaaku Zasshi 83. 815-17 (1963); (617) Kat‘ona, K . , Gyogyszereszet 3, 143-5 (1959), C.il. 58, 32746 (1963). (618) Kata, Al., Publ. Inst. Invest. Mzcroquim. Zlntv. Sacl. Lztoral 24 (22) 144-65 (1958), C.A. 57, 16752h (1962). (619) Kaufmann, H. P., Dah, B., Fette ‘ Seif., Anstrichmitt., 64 ( 3 ) , 214-217 (ld6Zi: And. ~-..~,. , . ~. Abstr. 9 . 4489 11962). (620) Kawai, S., Takeuc:hi, S.,’ Runseki Kagaku 10, 473-8 (1961); C.A. 58, 66469 (1963). (621) Kawamoto, H., Kumamoto M e d . J . 15 (2), 69-72 (1962); Anal. Abstr. 10, 2888 (1963). (622) Kazvak. L.. Knoblock. E. C., ANAL. CHEY.35, 1448-52 (1963). (623) Kediovski, AI., Ril. Farmats. Drusht. S R M 9 ( 2 ) , 1-5 (1962); Anal. .4bstr. 10, 3400 (1963). (624) Kelly, C. .4., Talanta 1 1 (2), 175-87 (1964). (625) Kerenyi, I., Gyogyszereszet 4 , 86-95 (1960); C‘A. 60, 5276k (1964). (626) Kerenyi, I., Pharm. Zentralh. 100 ~~~~
(12), 650-663 (1961); Anal. Abstr. 9, 2893 (1962). 1627) Kertesz. P.. Acta Pharm. Huno. 3 3 ’ ( 4 ) , 15011 (1963); C . A . 60, 154& (1964). (628) Kessler, W. \-., Christian, J. E., C:. S . At. Energy Comm. TID-14330, 7 pp. (1961); C . d . 59, 9736d (1963). (629) Kitazawa, T., Naito, AI., Yoshida, F., J . Pharm. Soc. Japan 80 ( I ) , 116-118 (1960); Anal. dbstr. 9, 4464 (1962). (630) Kho, B. T., Klein, S., J . Pharm. Sci. 52 (4),404-406 (1963). (631) Khorlin, A. Ya, Bochkov, A . F., I z v . A k a d . X a u k SSSR, Otd. Khim. LVauk 1962, 1120-1; C . A . 57, 12812b (1962). (632) K’imura, H., Yakugaku Zasshi 81, 1699-702 (1961): C . A . 58, 1301h i,----,. lQfX\
(633) Kimura, H., Ibzd., 81, 1703-5 (1961); C.A. 58, 1302d (1963). (634) Kirschner, ?*I. A , , Fales, H. A l . , ANAL. CHEY. 34 (12), 1548-1551 (1962). (635) Kiryakov, H., Compt. Rend. dcad Bulgare Sci. 16 ( l ) , 43-4 (1963); C.A. 60, 2723f (1964). (636) Ibid.. VD. 385-7 (1963): C.A. 60. 528lb (1Y64). (637) Kiss, L., Zajta, E., Rozsondai, B., Gyogyszereszet 6, 129-35 (1962); C.A. 57, 11315f (1962). (638) Klavehn, AI., Rochelmeyer, H., Seyfried, J., Deut. Apotheker-Ztg. 101 (4), 75-8 (1961); C . A . 60, 10477e i1964). (639) Kleflin, Z., Acta Pharm. Jugoslav. 11, 23-31 (1961); C.A. 57, 95% (1962). (640) Klein, S.,Kho, B. T., J . Pharm. Sci. 51 (lo),966-Y7i) (1962). (641) Kliman, B., Foster, I). W., Anal. Biochem. 3,,403-7 (1962). (642) Klimaviciene, E., I,ietuvos T S R Aukstuju hfokyklu Mokslo Ijarbai, M e d . 4, 197-205 (1963); C . A . 60, 2723e (1964). (643) Kloecking, H. P., Pharmazie 16, 604-ll(1961): C . A . 57, 2338a(1962). 16441 Kloerkinn. H. P.. I b i d . . 17. 218-19 (1462); ~ C . A , - j i SSii.7” , (1963): (645) Kloecking, H. P., Ibid., 18, 342-5 (1963); C.A. 59, 1,5120~(1963). (646) Kloeckinn. H. P . , 2. Chem. 2 (101, 310 (1962); Anal. Abstr. 10, 3424 i1963). (647) Kloecking, H. P., Z . M e d . Labortech. 3, 289-300 (1963); C . A . 59, 2591b (1963). (648) Kloecking, H. P., Joschko, E., 2. Chem. 2, 350 (1862); C.A. 58, 77849 (1963). (649)-Idid., p. 373 (1962); C..4. 59, 382d (1963). (650) Kluecking, H. P., Walter, H., Pharmazie 17, 277-80 (1962); C”..4.58, 10040b (1963). (651) Ibid., pp. 525-6; C.A. 58, 5453e (1963). (652) Klofutar, C., Pelan, B., Acta Pharm. Jugosl. 13 ( l ) , 3-12 (1963); Anal. Abstr. 10, 5355 (1963). (653) Klotz, L., Huettenraurh, R., Arch. Pharm. 296 ( l l ) , 721-5 (1963); C . A . 60, 5281a (1964). (654) Knabe, J., Pharm. Ztg. Ver. Apotheker-Ztg. 107, 69-71 (1962); C . d . 60,10476b(1964). (655) Knights, B. A., Thomas, G. H., A N A L . C H E Y . 34, 1046-8 (1962). (656) Knuppen, R., 2. Vitamin.-Horm.u.-Fermentforsch. 12 ( 5 ) ,355-401 (1963); Anal. Abstr. 10, 5335 (1963). (657) Kodama, Y., Hoshida, H., Tanabe, H., Yakuzaigaku 23, 158-62 (1963); C . A . 60, 2725e (1964). (658) Koen, V.,Farmatsiya, S o j a , 12 ( 3 ) , 36-40 (1962); ;InaZ. Ahstr. 10, 43.51 (1963). ~~
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I
VOL. 37, NO. 5 , APRIL 1965
s
205 R
(659) Koen, I b i d . , 13 (4),41--7 (1963); c'..i. 60, 2333h (1964). (660) Koenig, K., Pohloudek-Fabina, R., Pharrn. Zentrulhalle 99 i 11). 683-91 ( i ' ~ 6 0 ) ;c ? . . ~ .60, 9 i o ' ~ d( i w j . (661) Kotler, AI., Sornrner, P. F., Bo1liger, K. It., Schniidli, B., \-ecchi, AI., Vitamins and Hormones 20, 407-439 ( 1962); Anal. d b s t r . 10, 3464 (1963). (662) Kogan, 0. l t . j Famnatse (Kiez,) 18 [ l ) , 37-43 (1963): 111X7h (1963j . (663) Kolesnikova, \-. G., Sh. Trudy Odessk. .Iled. Inst. 1961 f 15)) 155-159; .Anal. :1bstr. 9, 5161 (l!t62). (661) Kolos-Pethes, E., Gyogyszereszet 4, 339--41 !1960): C7.A. 60, 5280h (1964). (665j Koluxeva, A , , &en, \.., Farinaciya 10,26-8 (1!160); C . d . 59, 2.5939 (1963). 1666) Kolusheva. A , . Xin'o. K..Parmat$iya ( s o ~ ~ u9) ' '(41, 36-40 ' ( i m ) ; C.A. 59, 1.5125e (1963). (667) Kolusheva, A . , Piin'o, X., Ibid., 13 (a), 21-5 (1963); C.21. 60. l542b \..)
~
(1964):
(668) Kolusheva, h., Toncheva, P., Ibid., 1 1 , (6) 13-18 (1961); ('..A. 58, 885ld (1963). (669) Konczal, LV., LIalek, B., Biul. Inst. lioslin Leozniczych 8 ( 4 ) , 145-50 (1962); c'.=l. 59, 8543g (1963). (670) Konecny, J., Pohoraky, J., \-ac'hek, J., ('esk. Parm. 12, 204-9 (1963): C . A . 59, 14429 (1963). (671) Konii, S., J . Pharm. Soc. Japan 82 (11) 1571-1573 (1962); Anal. d b s t r . 10, 5376 (1963). ( 6 7 2 ) Konkoly-Thege, I., Pungor, E., Schulek., R.. -Ann. I:nia. Sci. Budavest Rolando ~ o t v o sLVoAinatae, Sect. CiLzm. 2, 497-502 (1960), C . A . 57, 2334b (1962). (673) Konstantinova, El., Boichinov, Khr., Farmatsiya (Sofia)13 (4), 30-7 (1963); C.A. 60,2721e (1964). (674) Kopacova, L., Vrba, C., Farm. Obnor 32 ( l ) , 1-6 (1963); C.A. 60, 368c (1964). (675) Koppel, T'. I., Aptechn. DeZo 1 1 ( l ) , 40-4 (1962); C.A.57, 1 2 1 9 ~(1962). (676) Korchagin, T'. B., Erniakova, N . AI., Ilruzhinina, E. N., dntibiotiki 7 (5), 449-453 (1962); Anal. Abstr. 9, 5398 (1962). (677) Korchagin, V. B., Korobitskaya, A. A , . Chaikovskava. S. LI., I b i d . , 7 (6)) 562-566 (1962j; ' A n a l . Abstr. 10, 324 (1963). (678) Kori, S., Kono, M., J . Pharm. SOC. Japan 81, 776-8 (1961); Anal. Abstr. 9, 4877 (1962). (679) Kori, S., Kono, hl., Ibid., 82 (9), 1211-1213 (1962); Anal. Abstr. 10, 5356 (1963). (680) Kori, S., Tamaki, Y., Fujita, XI., [bid., 81 ( i ) ,980-984 (1961); Anal. dbstr. IO, 3840 (1963). (681) Korzun, B. P., Brody, S. XI., J . Chromatog. 7, 337-340 (1962). (682) Korzun, B. P., Brody, S., J . Pharm. Sei. 52 (2), 206-207 (1963). (683) Korzun, B. P., Dorfman, L., Brody, S. Xl., ANAL. CHEM. 35 (S), 950-2 (1963). (684) Koshy, K. T., hlitchner, H . , J . Pharm. Sei. 52, 802-3 (1963). (685) Kovach, A , , Vastagh, G., Acta Pharm. Hung. 29, 149-55 (1959); C A 57. 12633h 11962). (686j-K&!ach, A , , Vastagh, G., Gyogyszereszet 7 (9), 344-7 (1963); C.A. 60, -
" " _ V I
2
,-l--,.
(687) Kovacs, L., Ibid., 6,259-267 (1962); C.il. 57. 12837.1'(1962). (688) Kowalczyk-Kaniewska, T., Acta Polon. Pharm. 19 (4), 341-344 (1962), Anal. Abstr. 10, 3431 (1963). (689) Kowalewski, Z.,Biirl. Inst. Roslin 1,eczniczych 7 (3), 211-238 (1961): Anal. Abstr. 9, 4888 (1962).
206 R
0
ANALYTICAL CHEMISTRY
(690) Kozuka, H., Alotoyoshi, XI., Kagaku Keisatsu Kenkyusho Hokoku 16 (1)) 39-40 (1963); C . A . 59, 1512h (1863). (691) Kracniar, J., Pharmazie 16, 341-50 (1961); C..2. 57, 12630e (1962). (692) Kracmar, J., Sludkova, J., f b i d . , 18, 115-21 (1963); C.A. 59, 1438f i 1963 - -)., \ - -
(693) Ibid., pp. 350-3; C.A. 60, 1539f (1964). (694) Kracmar, J., Zyka, J., Ceskosl. Farm. 1 1 (9). 459-463 (19623: Anal. . .lbstr. 10, 3426 (1963). (695) Kracrnarova, J., Jindra, A., I b i d . , 1 1 (9), 457-459 (1962); Anal. Abstr. 10, 3427 (1963). (696) Kraua, P., Cesk. Farm. 12 ( 5 ) , 246-9 (1963); C.A.59, 8544f (1963). (697) Kraus, P., Simane, Z., Ibid., 10 (4j, 195-7 (1961); C.A. 60, 6703b (1964). (698) Krepinaky, J., Ibid., 1 1 (4), 205210 (1962); Anal. Abstr. 9, 4878 (1962). (699) Kreutxkamp, R., Hoelscher, P., Krenek, tl., Xlueller, ll., Deut. .4potheker-Ztg. 99, 1273-5 (1959); C..4. 60, 3948d (1964). (700) Krikova, ?i. I., Cchenye Zapiski, Pyatigorskii Farm. Inst. 3 , 138-43 (1959); C.A. 58, 12370f (1963). (701) Kristensen, K., Dansk Tidsskr. Farm. 36, 170-83 (1962); C.A. 58, 4378h (1963). ( 7 0 2 ) Krivis, A . F . , Supp, G . R., ANAL. CHEM.35 ( l o ) , 1411-12 (1963); C.A. 59, ll598d (1963). (703) Krogerus, \'. E., M e d d . l\rorsk Farm. Selskap 24, 1-6 (1962); C . A . 57, 13894b (1962). (704) Kubo, F., Imaoka, K., Kaneko, A , , Kyoritsu Yakka Daigaku Kenkyu ,Temp 6/7, 1-5 (1961/2); C.A. 60, 375d (1964). (705) I b i d . , pp. 5-8. (706) Kudymov, G. I., Savel'eva, G. I., Rubtsov, I-. K., M e d . Prom. S S S R 17 (IO), 41-4 (1963); C.A. 6 0 , 7873d (1964). ( 7 0 7 ) Kuehmstedt, H., Wagner, G., Pharm. Praxis, Beilagc! Pharmazie 1963 ( 8 ) , 152-60; C.A. 59, l5!19~ (1963). (708) Kulev, I., Dzhoneidi, hl., Neshkova, AI., Farmatsiya (Sofia) 13 (51, 16-23 (1963); C.A. 60, 6702e (1964). (709) Kunze, F. AI., Espinoza, L. B., J . Assoc. Oflc. Agr. Chemists 46 ( 5 ) , 899-901 (1963). (710) Kupcinskaite, R., Navickiene, B., Lietuaos T S R Aukstuju Mokyklu Mokslo Darbai, M e d . 4, 207-14 (1963); C.A. 60, 27219 (1964). ( i l l ) Kuroda, K., Yakugaku Zasshi 83, 445-54 (1963); C . A . 59, 11,192d (1963). (712) Lachman, L., ITrbanyi, T., Weinstein, S.,J . Pharm. Sci. 52, 244-9 (1963). (713) Lachman, L., Urbanyi, T., Weinstein, S., Cooper, J., Swartz, C. J., Ibid., 51, 321-6 (1962). (714) Ibid., pp. 326-9 (1962). (715) Lachman, L., Weinstein, S., Urbanyi, T., Ebersold, E., Cooper, J., Ibid., 52, 241-3 (1963). (716) Ladomery, L. G., Australasian J . Pharm. Suppl. N o . 44, 10-11 (1963); C.A. 58, 10041h (1963). (717) Lang, B., Horvath, G., Gyogyszereszet 6 , ( 5 ) 178-81 (1962); C . A . 57, 9956i (1962). (718) Langbein, G., Xleyer, hf., J . Chromatog. 8 , 442-448 (1962). (719) Larbre, Alrs. S., Ilorche, M. J., Bull. Trac. SOC.Pharm. Lyon 6 , ( 2 ) 61-2 (1962); C . A . 58, 66489 (1963). (720) Lnszlovszky, J., Barcza, L., Gyogyszereszet 7 (5-6), 192-6 (1963); C.A. 60, 3952h (1964). ( 7 2 1 ) Laszlovszky, J., Schulek, E., Acta I ,
Pharni.
Hung.
29, 217-22
(1959);
C.A. 57, 12634~(1962). (722) Laugel, P., Compt. Rend. 255 (4), 692-694 11962): , , , Anal. Abstr. 10. 3409 (1863). ( 7 2 3 ) Laugel, P., Hasselmann, 11.) Chim. Anal. 44 (lo), 433-435 (1962); Anal. d b s t r . 10, 2874 (1963). (724) Leal, A. AI., Inacio, M. XI. L., Leal, A I . AI. L., Rev. Port. Farm. 12, 476-81 (1962); C.A. 59, 1440h (1963). ( 7 2 5 ) Leal, A . M.> Lopes, AI. B. Y. R., Ibid., 13, 48-54 (1963); C.A. 59, 11188f 11963). (726) Lke; K . T.,.2nal. Chim. Acta 26 ( 3 ) , 285-289 (1962). ( 7 2 7 ) Lee, K. T., Ho, Y . H., J . Pharni. Pharmucol. 14 ( 2 ) , 123-124 (1962). ( 7 2 8 ) Lee, S., Putnani, iV. A., J . Appl. ('hem. (London) 13. 69-71 ilS63). (729) Leeman, H. G'., Stich,' K-,I'Helv. C ~ Z V LActa . 45, 1275-83 (1962); C.A. 57, 6246e (1962). (730) Lehman, It. W.,J . Pharm. Sci. 53 (2), 201-4 (1964). 17311 Lemmich. E.. Gialdbaek. .J. Chr.. ' Dansk 'I'idsskr. par& 37, lL8 ~(1963); C . A . 58, 10039e (1963). (732) Lenartowicz, K., Acta Polon. Pharm. 20 ( 3 ) , 233-235 (1963); Anal. Abstr. 1 1 , 1453 (1964). (733) Leonard, AI. A., J . Pharm. Phar~ U C O Z . 14 ( S u p p l . ) , 63T-65T (1962). (734) Lerner, AI.) hlills, A . L., Bull. 'Tarcotics, C:. S. Dept. Social Affairs 15 ( l ) , 37-42 (1963); C.A. 59. 3 7 1 9 ~ (1963). ( 7 3 3 ) Lerner, A l . , Alills, A . L., Mount, 5 . F., J . Forensic Sei. 8, 126-31 (1963). (736) Lespagnol, A., Devergnies, hl., Bull. SOC.Pharm. Lille 1961, ( 2 ) 85-7; C.A. 57, 11311b (1962). (737) Levine, J., J . Assoc. Ofic. Agr. Chemists 45, 595-7 (1962). ( 7 3 8 ) Levine, J., Ibid., 46 (4), 641-2 (1963). (739) Levine, J., J . Pharm. Sci. 52 (11), 1015-31 (1963). (740) Levine, T. E., Nachman, M., J . Forensic Med. 10,65-86 (1963). (741) Leyda, J. P., Harris, L. E., J . Pharm. Sci. 51. 725-8 (1962). (742) Liang, P., Chou, T.-H., Yao Hsueh Pao 8, 181-5 (1960); C.A. 57, 13888a (1962). (743) Liang, P., Chou, T.-H., Ibid., 10 (2), 87-90 (1963); C.A. 59, 13768h (1963). (744) Lidaks, hf., Lejins, Z., Shimanskay, M. V., T i o T E F A , Akad. S a u k Latv. S S R , Inst. Organ. Sinteza 1961, 9-17; C.A.58, 1304b (1963). (745) Linek, K., Peciar, C., Chem. Zvestz 16, 692-700 (1962); C.A. 58, 8409h (1963). 1746) Lipchinski, A., Kulev, I., Neshkova, XI.. Pharmazie 18. 616-18 (1963): -~-,, 6 0 , 1539d ~ C . A . 60, (1964). (747) Lippmann, I., Mattocks, A . AI., Sei. Sect. A m . Pharm. Assoc., Preprints Papers, Las Vegas, S e v . 1966, D-11, 11 DD.: C . A . 60. lt544e (1964). (748)'iishoa, B. P., Act Endocr. Copenhagen 43 ( l ) , 47-66 (1963); Anal. Abstr. 10, 5341 (1063). (749) Lisboa, B. P., J . Chromatog. 13 (2), 391-407 (1964). (750) Lisboa, B. P., Iliczfalusy, E . , Acta Endocr., Copenhagen 40 ( l ) , 6&81 (1962); Anal. Abstr. 10, 767 (1963). (751) Lisboa, B. P., Diczfalusy, E., Ibid., 43 (4), 545-560 (1963): Anal. Abstr. 1 1 , 1436 (1964). (752) List, P . H., Stein, E., Dtsch. ApothZtg. 102 (46), 1407-1498 (1062): Anal. Abstr. 10, 3846 (1963). (753) Litvinenko, I,. l l . , Arlozorov, D. G., Koroleva, T'. I., (,-ch. Z a p . Khar'kocsk. Lrniv., .Yo. 110, Tr. Khim.
?.A.
\
F a k . i L\Tauchn.-lssled. Inst. Khim.. Khar'koz1sk. Gos. c'nzz). S o . 17,-39-41 ( 1 9 6 l ) , C.A. 57, 2334e (1962). (754) Liukkonen, A,, -irch. Pharm. Chemi 68 ( l o ) , 493-500 (1961): Anal. Abstr. 9. 4876 ilYfi'2). (7.5,I., Serwin-Krajewska, M., Chem. Anal., Warsaw 7 (31, 653-657 (1962); Anal. :ibstr. 10, 2468 (1963). (814) AIazor, L., Papay, >'I K., . Acta Pharm. Hung. 32, 59-62 (1962); C.A. 57, 9569 (1962). (815) lledvesek, L., Farm. Vestnik (Ljubl-
j a n a ) 12 ( 5 - 8 ) , 97-108 (1961); C . A . 57, 73869 (1962). (816) Nedwick, T., Schiesuwohl, F., J . Pharm. Sci. 52 (Y), 843-6 i 1963). (817) Meier. G. S . . Kuhn. 0. S., d n a l e s Real Acad. Farm: 28, lb5-204' (196'2); C.A. 58, 8853d (1963). (818) Nelichar, B., Horka, J., Secesana, E., AIalt,a, U., C'esk. F a r m . 8 ( l o ) , 423-6 (1959); C'.z4. 60, 7873b (1964). (819) l\.lelichar, B., Jakubec, I., fbid., 9 ( 3 ) , 72-,5 (1960); C ' . A . 60, 787Yb (1964). (820) lIellinger, T. J., Keeler, C. E., J . Pharm. Sei. 51, 1169-73 (1962). (821) Melson, F., Hofmann, H., Pharni. Zentralh. 102 ( 2 ) , 59-69 (1963); A n a l . Abstr. 11, 337 (1064). (822) Menyharth, P , , A t r c h . I'harm. 295, 412-15 (1962); C ' . d . 57, 995Xb (1962). ( 8 3 ) Merlis, \-. AI., Bagreevu, 11. It., \.eselovskaya, G . G , j J l e d . Prom. S S S R 16, (11) 33-6 (1962); C'.d. 58, 12370h (1963). (824) LIerodio, J. C., An. dsoc. Qilin2. Argentina 49 ( 3 ) ,225-236 (1961): ine, H. hl., El-Alangouri, H. A , , Egypt. Pharm. Bull. 42, 325-33 (1960); C . A . 58, 1236% (1963). (914) Xuernberg, E., Ueut. ApothekerZtg. 101 ( l o ) , 268-9 (1961); f'.A. 60, 372h (1964). (515) Sussbaunier, P. A . , Pharni. Acta Helu. 37, 65-72 (1962); C . A . 57, 961b (1962). (916) Stissbacirner, P. A., Ibid., pp. 161168; Anal. Abstr. 9, 4456 (1962). (517) Sussbaunier, P. A , , Ibid., 38 ( l o ) , 758-66 (1963); C . A . 60, 1541 (1964). (918) Syiredy, S., Gogysterestet 6, 459-64 (1962); ('.&4. 58, 10039b (1963). (919) Syitray, L., Acta Pharm. Hung. 32, 27-29 (1962); Anal. Abstr. 9, 4879 (1962). (920) Oakey, R. E., J . Chromatog. 8, 2-16 (1962). (921j Oberzill, W . j Sci. Pharm. 30, 141-63 (1962); C.A. 58, 7784d (1963). (922) Ochab, S., Borowiecka, B., ('hem. Anal., Warsaw 8 ( l ) , 99-102 (1963); Anal. A b s t r . 10, 5363 (1963). (923j Ochab, S., Xalyaz, D.,Borowiecka, B., Ibid., 8 (4), 597-600 (1963); C . A . 60, 37Oc (1964). (924) Oelschlager, H., Arch. Pharm., Berlz'n 296 ( l ) , 7-13 (1963); Anal. Abstr. 10, 4886 (1963). (925) Okazaki, Y., Bunseki Kagaku 11, 1142-6 (1962); C.A. 58, 7786d (1963). (926) Ibid., pp. 1147-51. (927) Ibid., pp. 1239-42; C.A. 58, 88545 (1963). (928) Okazaki, Y.,J . Pharm. Soc. Japan 81, 1618-22 (1961); Anal. d b s t r . 10, 3880 (1963). (929) Okuda, S., Yamaguchi, S., Kawazoe, Y., Tsuda, K., Chem. Pharm. Bull. ( T o k y o ) 12 (1)) 104-12 (1964); C.A. 60, 1 4 0 3 0 ~(1964). (930) Okuda, Y., Horino, S., Xlasaki, H., Furukawa, Y,,Yamasaki, 11.) Rev. Polarog. (Kyoto) 9, 174-6 (1961); C.A. 60, 5279d (1964). (931) Olechnowicz-Stepien, W., Rzadkowska, H., Dissert. Pharm., Krakow 14 (3), 331-338 (1962); Anal. Abstr. 10, 3418 (1963). (932) Omboly, C., Derzsi, E., Acta Pharm. Hung, 32 (6), 246-250 (1962); Anal. dbstr. 10, 3886 (1963). (933) Onesanu, D., Acad. Rep. Populare Romine, Studii Cercetari Biochim. 6 ( 2 ) , 281-4 (1963); C.A. 59, 111896 (1963). (934) Opavsky, J., Moudry, R., Tech. Publ. Stredisko Tech. Inform. Potracinar. Priimudu 139. "106-10 11963): ?..4.-GO, 6706; (1964j. (935) Ordonez, C. R., Celsi, S. A., Rev. Farm. (Buenos ilires) 104 (3-4)) 55-61 (1962); C . A . 57, 9956a (1962). 936) Orlov. Yu. E., Dzvuba, S . P., Shostenko, Yu. V,, Farmatsevt. Zh. (Kzev) 18 ( 5 ) , 36-9 (1963); C.A. 60, 527Qh l-.ll IlR64'I \
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_
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