Pharmacokinetics and metabolism of hexachlorobenzene in the rat

Pharmacokinetics and metabolism of hexachlorobenzene in the rat and the rhesus monkey. Raymond S. H. Yang, K. A. Pittman, D. R. Rourke, and V. B. Stei...
1 downloads 0 Views 1MB Size
1076

J. Agric. Food Chem., Vol. 26, No. 5, 1978

Yang et al.

Pharmacokinetics and Metabolism of Hexachlorobenzene in the Rat and the Rhesus Monkey Raymond S. H. Yang,*' K. A. Pittman,2 D. R. R ~ u r k eand , ~ V. B. Stein4

The metabolism of hexachlorobenzene (HCB) has been studied with respect to its tissue distribution, disposition, pharmacokinetics, and biotransformation in rats and rhesus monkeys. Preliminary results using the rat for a short-term (48 h) study indicate that a very small portion (