Photothermal Effect Enhanced CascadeTargeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@Mesoporous Silica Nanorod Ruifang Zhao,†,‡,§,# Xuexiang Han,†,‡,§,# Yiye Li,*,†,§ Hai Wang,†,§ Tianjiao Ji,†,⊥ Yuliang Zhao,†,§ and Guangjun Nie*,†,§ †
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China ‡ Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China § University of Chinese Academy of Sciences, Beijing 100049, P. R. China ⊥ Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, United States S Supporting Information *
ABSTRACT: Pancreatic cancer, one of the leading causes of cancer-related mortality, is characterized by desmoplasia and hypovascular cancerous tissue, with a 5 year survival rate of
