pubs.acs.org/Langmuir © 2010 American Chemical Society
Physicochemical Characterization of Nanotemplate Engineered Solid Lipid Nanoparticles Melissa D. Howard,† Xiuling Lu,‡ John J. Rinehart,§ Michael Jay,‡ and Thomas D. Dziubla*,^ †
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, Lexington, Kentucky 40536-0596, United States, ‡Division of Molecular Pharmaceutics, Eshelman School of Pharmacy and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB#7571, Chapel Hill, North Carolina 27599-7355, United States, §The Markey Cancer Center, Division of Hematology, Oncology, Blood and Marrow Transplantation and the Experimental Therapeutics Program, University of Kentucky, 800 Rose St., Lexington, Kentucky 40536-0293, United States, and ^ Department of Chemical and Materials Engineering, University of Kentucky, 177 F. Paul Anderson Tower, Lexington, Kentucky 40506-0046, United States Received October 23, 2010. Revised Manuscript Received December 8, 2010 As the physicochemical characteristics of solid lipid nanoparticles (SLNs) play a critical role in their success, it is important to understand how the materials and process used in their preparation affect these properties. In this study, two stearyl alcohol-based formulations were prepared using nanotemplate engineering technology and characterized. Both formulations were of a small particle size (
