Placental Metal Concentrations in Relation to ... - ACS Publications

Jan 4, 2016 - The study protocols for the New Hampshire Birth Cohort Study (NHBCS) were approved by the Committee for the Protection of Human Subjects...
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Placental metal concentrations in relation to maternal and infant toenails in a US cohort Tracy Punshon, Zhigang Li, Carmen Marsit, Brian P. Jackson, Emily R Baker, and Margaret Karagas Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.5b05316 • Publication Date (Web): 04 Jan 2016 Downloaded from http://pubs.acs.org on January 10, 2016

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Environmental Science & Technology

Maternal post-partum toenails N=565

Placenta N=750

Cd Pb Hg Mn Se Zn

Infant toenails N=360 ACS Paragon Plus Environment

Environmental Science & Technology

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Placental metal concentrations in relation to maternal and infant toenails in a US cohort

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Tracy Punshon*1, Zhigang Li2, Carmen J. Marsit2, Brian P. Jackson2, Emily R. Baker3 and Margaret R.

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Karagas2

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Running head: Metals in placenta

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Dartmouth College, Department of Biology, 78 College Street, Hanover, NH, 03755

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2

Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755

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Dartmouth Hitchcock Medical Center, Department of Obstetrics and Gynecology, One Medical Center

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Drive, Lebanon, NH, 03756

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*Address correspondence and reprint requests to:

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Tracy Punshon, PhD

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Research Assistant Professor

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Department of Biology, Dartmouth College

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78 College Street

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Hanover, NH 03756

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Tel: (603) 646 1037

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Fax: (603) 646 1347

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[email protected]

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ABSTRACT

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Metal contaminants cross the placenta, presenting a heightened risk of perturbing fetal development.

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Information on placental concentrations and transfer of multiple potentially toxic metals from low to

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moderate exposure is lacking. We measured concentrations of Cd, Pb, Hg Mn, Se and Zn in 750 placentas

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collected from women enrolled in the New Hampshire Birth Cohort Study and examined the correlation

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between elements, and profiles of potentially toxic metals (Cd, Pb, Hg and Mn) stratified by nutrient

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concentrations (Zn and Se) using Principal Components Analyses (PCA). We further examined the indirect

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effects of maternal metal concentrations on infant metal concentrations through placenta metal

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concentrations using structural equation models. Placental metal concentrations were all correlated,

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particularly Zn and Mn, and Zn and Cd, and the principal component of metals differed by stratum of high

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versus low Zn and Se. Associations were observed between placenta and maternal toenail Se (β 63.49,

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P