Potent, Cell Active, Non-Thiol Tetrapeptide Inhibitors of


John T. Hunt,*,† Ving G. Lee,† Katerina Leftheris,† Bernd Seizinger,‡ Joan Carboni,‡ John Mabus,‡ Carol Ricca,‡. Ning Yan,‡ and Veeras...
0 downloads 0 Views 147KB Size

Recommend Documents


Farnesyltransferase Inhibitors: From Squalene Synthase Inhibitors to the Clinical Agent BMS-214662. John T. Hunt. 2001,199-213. Abstract | PDF | PDF w/ Links.

Oct 19, 2012 - ABSTRACT: The histone H3-lysine 27 (H3K27) methyl- transferase EZH2 plays a critical role in regulating gene expression, and its aberrant ...

aReagents and conditions: (a) KNO3, H2SO4, 0 °C (94%); (b) hydrazine hydrate ..... (22, 44) Unlike other Mps1 kinase inhibitors 1, 2, and 3, indazoles 32a and ...... The mixture was poured into ice water, and the resulting solid was collected on ...

May 1, 2013 - Indazole-Based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125). Ken-ichi ... *Phone: +81 6 6331 6190. Fax: +81 6 6332 ... Thus, selective Mps1 inhibitors offer an attr

May 1, 2013 - Ana Rita R. Maia , Simon Linder , Ji-Ying Song , Chantal Vaarting , Ute Boon , Colin E. J. Pritchard , Arno Velds , Ivo J. Huijbers , Olaf van ...

Publication Date (Web): August 26, 2016 ... hydroxylactams was identified as potent enzymatic and cellular inhibitors of human lactate dehydrogenase A. Utilizing structure-based design and physical property optimization, multiple inhibitors were disc

Aug 30, 2017 - ACS AuthorChoice - This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, .... and ultimately cellular activity, a campaign that led to the discovery of inhibitor

Aug 30, 2017 - Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3 ..

Aug 30, 2017 - Johannes PopowHeribert ArnhofGerd BaderHelmut BergerAlessio CiulliDavid CoviniChristian DankTeresa GmaschitzPeter GrebJale ...

Aug 30, 2017 - Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity ...