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Ecotoxicology and Human Environmental Health
Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFASs) and Association between the Placental Transfer Efficiencies and Dissociation Constant of Serum Proteins-PFAS Complexes Ke Gao, Taifeng Zhuang, Xian Liu, Jianjie Fu, Jingxing Zhang, Jie Fu, Liguo Wang, Aiqian Zhang, Yong Liang, Maoyong Song, and Guibin Jiang Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.9b00715 • Publication Date (Web): 17 May 2019 Downloaded from http://pubs.acs.org on May 20, 2019
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Environmental Science & Technology
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Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFASs)
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and Association between the Placental Transfer Efficiencies and
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Dissociation Constant of Serum Proteins-PFAS Complexes
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Ke Gao,†,‡,# Taifeng Zhuang,§,# Xian Liu,† Jianjie Fu,†,* Jingxing Zhang,†, Jie Fu,†,‡
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Liguo Wang,†,‡ Aiqian Zhang,†,‡,
,
Yong Liang , Maoyong Song,† Guibin Jiang†,‡
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†
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Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
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‡
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
College of Resources and Environment, University of Chinese Academy of Sciences,
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Beijing, China
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§
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Medical University, Beijing, China
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Department of Pediatrics, Beijing Obstetrics and Gynecology Hospital, Capital
Institute of Environment and Health, Jianghan University, Wuhan, Hubei, China
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* Corresponding author:
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Dr. Jianjie Fu; Tel.: +86-10-6284-9357; E-mail:
[email protected] 16
# These
authors contributed equally to this work
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Environmental Science & Technology
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Abstract
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Information on placental transfer and adverse outcomes of short-chain per- and
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polyfluoroalkyl substance (PFASs) is limited, and factors responsible for PFAS
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placental transfer are still unclear. In the present study, concentrations of 21 PFASs
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were analyzed in 132 paired maternal and cord serum samples collected from residents
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in Beijing, China, and placental transfer efficiency (PTE) of each PFAS was calculated.
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PTEs of short-chain perfluoroalkyl acids (PFAAs), including PFBA (146%), PFBS
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(97%), PFPeA (118%) and PFHxA (110%), were firstly reported, and a complete U-
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shape trend of PTEs from C4 to C13 of perfluoroalkyl carboxylic acids (PFCAs) were
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obtained. Positive association between maternal weight and PTE of perfluorooctane
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sulfonate (PFOS) (p
