Preparation and antimalarial activity of compounds related to dypnone

William T. Colwell, George W. Chan, J. K. Horner, R. M. Parkhurst, and David W. Henry. J. Med. Chem. , 1971, 14 (1), pp 70–72. DOI: 10.1021/jm00283a...
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70 Journal of Medicinal Chemistry, 1971, Vol. 14, No. 1

NOTES

as Quevauviller’ has pointed out, must exist between the lipophilic and hydrophilic portion of the molecule for it to exhibit potent local anesthetic activit?. Hydrophilicity in the case of G-I