Products and
Bοοks on Cosmetics
Processes
For further information o n any item m e n t i o n e d here, fill out c o u p o n o n p . 2 1 1 0 .
Winter, F.:
Riechstoffe
und
Parfumierungstechnik. Muller,
Α.:
$9.00
Internationaler
Riechstoff-Kodex. Gerhardt, O . :
$9.00
Komponieren in
der Parfumerie.
$12.50
Mann, H.: Moderne Parfumerie. $10.00
J. W . EDWARDS Michigan
Ann Arbor
ISOTOPE
T h e synthesis of vitamin A in a high Mate of purity was described in a recent issue of Helvetica CJtimicn Acta (32, 443-52 [1949]) b y a group of workers from the W a r n e r I n s t i t u t e for T h e r a peutic Research. Complete identity b e tween t h e n a t u r a l and synthetic product has b e e n established by chemical, physico-chemical, and biological m e t h o d s . A m e t h o d suitable for commercial p r o duction has also been worked o u t . Starting with a C\* ketone first d e scribed b y Heilbron. the researchers added two carbon atoms and obtained a mixture of vitamin A acid a n d ester which was successfully reduced to t h e vitamin b y t h e use of lithium a l u m i n u m hydride, a reducing agent which does not attack carbon-to-carbon double bonds. T h e end product had a p u r i t y of 50 t o 7nr/-aminobenzoic acid, are packaged in 1-millicurie a m o u n t s . T h e />-aminobcnzoic acid m a y b e obtained in vials containing 0.5 mc. activity. Handling charges a n d procurement procedures are as outlined in Circular E-39. ρ 2 Specific Activity
Price per millicurie
Compound
Formula
Nicotinic acid (carhoxyl labeled)
XXCOOII
4.5 mc. per m m o l e
$125
Nicotinamide (carbonyl labeled)
XXCONH2
4.8 m c . p e r m m o l e
150
Urea
NH2CONH2
4 m c . per m m o l e
125
Anthranilic acid (carboxvl labeled)
/'NcOOIJ > L JNII2
3.7 mc. per m m o l e
150
4.6 mc. p e r m m o l e
150
FATTY ACIDS Potassium propio nate-1-C" 0 . 5 inc. Potassium butyratc1-C>« 0 . 5 inc. 14 Stearic acid-1-C 0 . 5 inc.
of its acetate, starting from /3-ionone, an aromatic oil with t h e pleasant odor of violets, has now b e e n performed on a sufficiently large scale t o p e r m i t its use in pharmaceutical preparations. The first pharmaceutical product, vitamin A capsules, will be m a r k e t e d i n this coun try b y William R . W a r n e r & Co., I n c . T h e y are said to b e t h e smallest gelatin capsules of v i t a m i n A ever manufac tured (25,000 U.S.P. units per capsule) and completely free from a n y fishy odor or taste. Ρ 1
Isotope-Labeled Compounds Now
Labeled Compounds 2,4-D
Commercial Process for Synthesizing Vitamin A
^*
DEUTERATED COMPOUNDS D e u t e r a t e d methanol 1 g. Deuterated methyl chloride 1 p. Deuterated methyl bromide 1 g. Deuterated methyl iodide 1 g. D e u t e r a t e d a m m o n i a 1 mole 100 ml. (gas) Deuterated methane 1 mole
1 2 5 . 0 0 . g. 15O.0O/g. 125.0Ο, g. I00.00/g. 500.00/mole 50.00 500.00/mole
Complete Radiochemical Research Facilities Available
TEXAS RESEARCH FOUNDATION RENNER
TEXAS
p-Aminobenzoic acid (carboxyl labeled)
COOH ρ Ν NH2
2106
NH2
CHEMICAL
AND
ENGINEERING
NEWS
ganic builders such as t e t r a s o d i u m p y r o phosphate. Ρ 3
Food Product N u t r i t i o n i s t s a t t h e U. S. D e p a r t m e n t of Agriculture h a v e developed a soybean protein product for use in place of whipped egg whites for m a k i n g meringue. T h e new product, called Gelsoy, elimi nates t h e shrinkage, w a t e r y characteris tics, toughness, and stickiness often as sociated with egg meringue. Ρ 4
Sodium
Greatest Improvement in Water Stills in 25 Years
Amide
T h e F a r c h a n Research Laboratories announces t h e availability of sodium amide for t h e first t i m e as a free flowing powder. I n this convenient form it is ready for i m m e d i a t e use. Sodamide should p r o v e of great interest as a valuable condensing agent in t h e m a n u facture of pharmaceuticals, perfume in termediates, fine chemicals, a n d general organic synthesis. I t s use is well known in such reactions as t h e Claisen conden sation, alkylations and acylations of ketones, animations, and ring closures, the manufacturer states. I» 5
Muscle Adenylic
Acid
Adenosine-5-phosphoric acid ( A M P ) , the adenine nucleotide usually called muscle adenylic acid, is now available from Schwarz Laboratories, I n c . M a d e by a process t h a t does not require the use of animal tissues, this basic constit uent of such vital co-enzymes as A T P and C o e n z y m e I is offered in virtually unlimited quantities. A n i m p o r t a n t bio chemical substrate, it has been used clinically in t h e t r e a t m e n t of cardiac af flictions, some types of r h e u m a t i c condi tions, and malnutrition. T h e isomeric nucleotide adenosine-3-phosphoric acid, yeast adenylic acid, is also m a d e by Schwarz. V 6
TtUdete
~7&e ffa* m Polished Stainless Steel Exterior • Streamlined Construction • Disassembly in 10 Seconds Without Tools • Built-in After-Cooler • Compact • Tall, Large-Diameter Vapor Flue • New Improved "VaporMaze" Multiple Baffle and Vapor Scrubber • Λ11 Models Suitable for Hard Water • Easiest to Clean, Inside and Out • Simple to Install SEE YOUR LABORATORY
Product Notes
Inlet Water Preheated Complete Liberation of Gases Block-Tin-Coated Inside Surface Steam, Gas, or Electric Heated Models Capacities from 1 to 4 G.P.H. Automatic Operation "Concentube" Condenser —Easy to Clean Ail Models suitable for Table or Wall Mounting Write for Literature SUPPLY
DEALER
Precision Scientific Compami
T h e Stalwart R u b b e r C o . announces the production of silicone r u b b e r b o n d e d to Fiberglas, asbestos, wool, or cotton. Bonding this versatile synthetic rubber to these materials greatly increases its strength. Ρ 7
3737
W
CORTLAND
ST.
CHICAGO
47.
ILL
U S A .
OFFICES IN CHICAGO, NEW YORK. PHILADELPHIA. SAN FRANCISCO DEALERS IN ALL PRINCIPAL CITIES
American Cyanamid C o . announces that its catalytic plasticizer, P e p t o n 22, is now being added to crude rubber in latex form right at t h e p l a n t a t i o n . This means t h a t rubber products manufac turers in t h e United States can eliminate a difficult step in processing and can receive raw rubber which is partially plasticized a n d will require a b o u t onehalf t h e mastication n o r m a l l y required. P8 V O L U M E
2 7,
NO.
2 9
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JULY
18,
1949
2107
