Protein Aggregation and Performance Optimization Based on

(1,2) Protein aggregation usually leads to lower biological potency, altered ... proteins, the manufacturing process, container quality, and storage c...
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Protein aggregation and performance optimization based on microconformational changes of aromatic hydrophobic regions Lili Wen, Man Lyu, Huashuai Xiao, Hairong Lan, Zhili Zuo, and Zongning Yin Mol. Pharmaceutics, Just Accepted Manuscript • DOI: 10.1021/acs.molpharmaceut.8b00115 • Publication Date (Web): 25 Apr 2018 Downloaded from http://pubs.acs.org on April 26, 2018

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is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Published by American Chemical Society. Copyright © American Chemical Society. However, no copyright claim is made to original U.S. Government works, or works produced by employees of any Commonwealth realm Crown government in the course of their duties.

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