pyrimidine Lipophilic Antifolates as Inhibitors of Pneumocystis carinii

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Additions and Corrections

1997, Volume 40

Andre Rosowsky,* Andrew T. Papoulis, and Sherry F. Queener: 2,4-Diaminothieno[2,3-d]pyrimidine Lipophilic Antifolates as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase. Pages 3695, 3697. It was stated in the footnote to Scheme 1 on p 3695, in line 3 from the bottom in the right-hand column on p 3695, and in line 14 from the top in the left-hand column on page 3697 that the reaction of 2,4-diamino-6-mercaptopyrimidine with chloroacetone to form 2,4-diamino-5-methylthieno[2,3-d]pyrimidine could be carried out in the presence of potassium bicarbonate in DMF. However, several attempts to replicate this experiment have proved to be unsuccessful, and we therefore recommend that the reaction should continue to be done with NaOMe in ethylene glycol as originally reported in the following reference: Roth, B.; Laube, R.; Tidwell, M. Y.; Rauckman, B. S. J. Org. Chem. 1980, 45, 3651-3657. JM030231R 10.1021/jm030231r Published on Web 06/17/2003