CHARTI
m
second fluorine as well. This approach was therefore abandoned. Treatment of I1 with 1 mole of sodium ethoxide (see Chart 11) yielded 2-amino-4-ethoxy-6-fluoropyrimidine
P
A separation was finally accomplished by the use of steam distillation. The steam volatile isomer, which was isolated (66%) in a crystalline state, mas proved to be 2-amino-4,6-difluoropyrimidine (11). Unfortunately, the nonvolatile isomer, 4-amino-2,6-difluoropyrimidine (111), was isolated in very poor yields (
