Qualitative and Quantitative Analysis of Small Amine Molecules by

Jul 16, 2004 - Peter J. Lee, Weibin Chen, and John C. Gebler*. Life Science Chemistry, Waters Corporation, 34 Maple Street, Milford, Massachusetts 017...
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Anal. Chem. 2004, 76, 4888-4893

Qualitative and Quantitative Analysis of Small Amine Molecules by MALDI-TOF Mass Spectrometry through Charge Derivatization Peter J. Lee, Weibin Chen, and John C. Gebler*

Life Science Chemistry, Waters Corporation, 34 Maple Street, Milford, Massachusetts 01757

A pair of isotopically coded light and heavy reagents, tris(2,4,6-trimethoxyphenyl)phosphonium acetic acid N-hydroxysuccinimide esters (1 and 2) were synthesized and used to derivatize low molecular weight (