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chanistic themes in bioactive substances. Syn- thesizes the latest work of scientists in indus- trial, academic, and government laboratories. Probes t...
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Probing Bioactive Mechanisms Edited by

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Probing Bioactive Mechanisms • Jew! Reveals innovative techniques in f l f statistics and computer modeling that A W are being used to study common mechanistic themes in bioactive substances. Synthesizes the latest work of scientists in industrial, academic, and government laboratories. Probes the common molecular mechanisms in three diverse fields-medicinal chemistry, agrochemicals, and chemical toxicology. Details experimental, statistical, and computational approaches coupled with SAR and QSAR studies for developing and detecting drugs, pesticides, and toxic substances. Describes a variety of statistical and modeling approaches to designing biologically active molecules, elucidating structure-activity relationships, and defining the characteristics of the receptor and receptor-ligand interaction. Blends theory and applications in twenty-four chapters covering the following topics: • an overview of the design of bioactive molecules; prediction of mechanism and activity, and the interface of statistics, quantum chemistry, and molecular modeling • new tools for the study of bioactive mechanisms, including SAR in three dimensions and micellar liquid chromatography with QSAR studies • sixteen uses of computational analysis techniques to study bioactive mechanisms in agrochemicals, drugs, and toxic substances Medicinal, environmental, toxicological, and agrochemical scientists with a basic interest in QSAR and modes of action will welcome this most current approach to the study of bioactive compounds. John H. Block, Editor, Oregon State University Douglas R. Henry, Editor, Molecular Design Limited Philip S. Magee, Editor, Biosar Research Project Developed from a symposium sponsored by the Division of Agrochemicals of the American Chemical Society ACS Symposium Series No. 413 400 pages (1989) Clothbound ISBN 0-8412-1702-5 LC 89-17988 $59.95

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