Chem. Res. Toxicol. 2001, 14, 609
Additions and Corrections Metabolism of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Human Hepatocytes: 2-Amino-3methylimidazo[4,5-f]quinoxaline-8-carboxylic Acid Is a Major Detoxication Pathway Catalyzed by Cytochrome P450 1A2 [Volume 14, Number 2, February 2001, pp 211-221] SOPHIE LANGOUE¨ T, DIETER H. WELTI, NATHALIE KERRIGUY, LAURENT B. FAY, TUONG HUYNH-BA, JOVANKA MARKOVIC, F. PETER GUENGERICH, ANDREÄ GUILLOUZO AND ROBERT J. TURESKY* Figure 2, page 217. The figure legend should read as follows: Effect of furafylline on MeIQx metabolism in human hepatocytes. The cells were pretreated for 48 h with 0.1, 1, or 5 µM furafylline (from left to right in each histogram), and the amounts of the various MeIQx metabolites were calculated as a percentage of (A) 10 or (B) 1 µM MeIQx used for the treatment. Two independent analyses were performed, and the estimation of metabolite formation was within 15%. One-way ANOVA (p < 0.010) and the post-test linear trend (p < 0.01) for IQx-8-COOH, HON-MeIQx-N2Gl, and MeIQx at 1 and 10 µM MeIQx and 7-oxo-MeIQx at 1 µM MeIQx as a function of furafylline. TX010498Y 10.1021/tx010498y Published on Web 05/05/2001
609
