R2 R3 OH HN HO R2 R4 * cyclization N R4 R3 H + reductive

Page 1. R2 R3 OH HN HO R2 R4 * cyclization N R4 R3 H + reductive cross coupling N R4 R3 R2 R1 R1 R1 * * * * * dr up to 50:1 R1 R2 OH ...
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Allylic alcohol – Alkyne Cross-Coupling: OH

R1

reductive

R1

+

R3

R4

R2

R2

cross-coupling

R3 rr ≥ 20:1 dr up to 99:1

Imine – Alkene Cross-Coupling: R4

HO R2

R1 *

+

reductive

N R3

H

R4

OH

cross R1 * coupling

HN

R4

cyclization

* * R3 R2

R4 R * N * R3 1

* R2

dr up to 50:1 Alkene – Alkyne Cross-Coupling:

reductive

HO R1

( )n

+

R2

R3

R2

OH

R3

( )n

cross-coupling

R1 rr ≥ 20:1 dr up to 20:1

Imine – Alkyne Cross-Coupling:

+

1

R

N

R2

carbonylative

R1 N

cross-coupling

R3

R2

R3



R1 R2

+

R4

R3 rr ≥ 20:1

Allene – Alkyne Cross-Coupling: OH

OH

O

OH

R5

OH

reductive cross-coupling

R4 R5

R1 R2 R3 rr ≥ 20:1