Rare Sugar Syrup Containing d-Allulose but Not High-Fructose Corn

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Rare Sugar Syrup Containing D-Allulose, but not High Fructose Corn Syrup, Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats Tomoya Shintani, Takako Yamada, Noriko Hayashi, Tetsuo Iida, Yasuo Nagata, Nobuaki Ozaki, and Yukiyasu Toyoda J. Agric. Food Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jafc.6b05627 • Publication Date (Web): 16 Feb 2017 Downloaded from http://pubs.acs.org on February 18, 2017

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Journal of Agricultural and Food Chemistry

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Rare Sugar Syrup Containing D-Allulose, but not High Fructose Corn Syrup,

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Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic

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Glucokinase Translocation in Wistar Rats

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Tomoya Shintani*, †, Takako Yamada†, Noriko Hayashi†, Tetsuo Iida†, Yasuo Nagata‡,

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Nobuaki Ozaki#, and Yukiyasu Toyoda⊥

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Itami, Hyogo 664-8508, Japan

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1-14 Bunkyo-machi, Nagasaki 852-9521, Japan

Research and Development, Matsutani Chemical Industry Co., Ltd., 5-3 Kita-Itami,

Center for Industry, University and Government Cooperation, Nagasaki University,

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#

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Nagoya, Aichi, 453-8511, Japan

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Japanese Red Cross Nagoya Daiichi Hospital, 3-35 Michishita, Nakamuraku-ku,



Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, 150

Yagotoyama, Tempaku-ku, Nagoya, Aichi,468-8503, Japan

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ACS Paragon Plus Environment

Journal of Agricultural and Food Chemistry

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ABSTRACT

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Ingestion of high fructose corn syrup (HFCS) is associated with the risk of both

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diabetes and obesity. Rare sugar syrup (RSS) has been developed by alkaline

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isomerization of HFCS and has anti-obesity and anti-diabetic effects. However, the

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influence of RSS on glucose metabolism has not been explored. We investigated

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whether long-term administration of RSS maintains glucose tolerance and whether the

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underlying mechanism involves hepatic glucokinase translocation. Wistar rats were

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administered water, RSS, or HFCS in drinking water for 10 weeks, and then evaluated

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for glucose tolerance, insulin tolerance, liver glycogen content, and subcellular

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distribution of liver glucokinase. RSS significantly suppressed body weight gain and

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abdominal fat mass (p