RESEARCH • Sufferers of hypertension can look duced /V-dimethylaminoethyl tetraforward t o relief b y use of a n e w drug chlorophthalimidine. Other studies called Ecolid. T o be produced and show that hydroxyphthalirnidine is in marketed in the near future b y Ciba termediate to the phthalimidine. Pharmaceutical, this ganglionic block Key to the process came from theo ing: agent can be made in large quanti retical calculation, continues Allen, ties by a n electrochemical reduction of that indicated a good yield of t h e isothe intermediate ZV-dimethylaminoethyl indoline might b e obtained if a medium tetirachlorophthalimide to t h e respec were used in which calculated current tive isoindoline says M. J. Allen, direc density did not result in hydrogen evo tor of Ciba's physical research labs. lution a t the cathode. This means a E\evealing - the new process a t the system is required which would in 108th meeting of the Electrochemical crease t h e overpotential of an electrode Society i n Pittsburgh, Allen adds that such as lead or mercury beyond that recL-uction b y conventional chemical which could b e obtained in aqueous me-aus gives relatively low yields be sulfuric acid. cause of the substituted phthalimide's Such a system, adds Allen, is an low?- solubility in the solvent systems aqueous solution of sulfuric acid con use~d. But, b y electrochemical method taining acetic acid. This medium has it Ls possible to increase yields t o the the added advantage of being a good ordler of 8 5 % . solvent for the starting material and T h e isoindoline, Allen continues, is contributes to good yields and current isolated from the electrolysis medium efficiency. by making t h e catholyte basic. The resulting precipitate is extracted with eth-er, evaporated, and then extracted witlh pentane. Subsequent evaporation Reducing Smog yields IV-dimethylarninoethyl tetrachloroisoindoline. This compound is Use of different auto fuels to them quarternized to form t h e new drutg. reduce smog is impractical; Mechanism studies of t h e electro unleaded gas a n d catalytic lytic process, says Allen, indicate that converters offer promise bot£h carbonyl groups of the tetrachlorophthalimide are not reduced simtultaneously. If t h e reaction is O F THE MANY WAYS suggested to allowed t o proceed approximately 45% reduce smog is to use alternate auto of t h e time required t o give optimum fuels. This proposal is impractical, ac yield of t h e isoindoline, the major com cording to an Air Pollution Foundation ponent isolated would b e partially re- report. A study conducted by South-
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€. C. Closing date is Dec. 1.
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Contract
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University of Arizona Mechanism of Heterogeneous Low Temperature Ortho Hydrogen Conversion Canisius College Investigations in Irradi'; vd Vitreous Silica Carnegie Institute of Technology Standard Free Energy of Formation of Certain Rare Earth Carbides Effects of Irradiation on Surface Reactions
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tctivities at the Laboratory will be sent upon request.
P R & f i i S I O N
r 4800
cts for research research in the physical AEC has a w a r d e d 69 unclassified contracts physical sciences. Eighteen are new, t h e remainder renewals. Among Ajnong the n e w are:
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JET
AEC Grants 69 Contracts
C&EN
LABORATORY
UFORNIA INSTITUTE OF TECHNOLOGY 4800 OAK GROVE DRIVE PASADENA 3, CALIFORNIA
NOV.
7,
1955
Clark University Reactions of Partially Chelated Metal Ions Columbia University Structure of Metallic Liquids Duke University Ion Exchange in Polar Nonaqueous Solvents New York University Thermodynamic Properties of Sodium-Potassium Alloys Ohio University Reaction o£ Uranium v/ith^ Solutions of Ammonium Salts in Liquid AmniOiiia Pennsylvania State University Study of Release of Chemisorbed Gases on Graphites by Thermal and Chemical Treatment Stevens Institute of Technology Effect of Radiation on Solids
Investigator Chapin, Douglas S. Szymanski, H e r m a n A.
Amount $ 8,415 2,420
McCabe, C . L.
nn 4 0 n
Simnad, Massoud T . Smoluchowski, R.
34,000
Martell, A. E.
11,000
Gordon, R.
4,967
Strobel, H o w a r d A.
4,420
Sundheim, B. R .
9,000
Kline, Robert J .
4,850
Walker, P . L., Jr. Hippie, J. A. Johnson, E . R.
13,100
r\ Q(\n
