Relationship Between Chemical Structure and Toxic Action on Rats

Soc. , 1954, 76 (6), pp 1714–1714. DOI: 10.1021/ja01635a090. Publication Date: March 1954. ACS Legacy Archive. Cite this:J. Am. Chem. Soc. 76, 6, 17...
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tion of 3-acetylpyridine and adenosinediphosphate ribose and the two components can be separated on a Dowex formate column. 3--icetylpyridine can be washed off the column with water and can be identified spectrophotometrically as illustrated in Fig. 1. The absorption spectrum presented is identical with free 3-acetylpyridine as shown b y the peak at 230 mp.4 The spectrum of nicotinamide released from D P N by the same treatment is coinpared with the product of cleavage of the acetyl-



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