Retraction pubs.acs.org/jmc
Retraction: Synthetic N‑Acetyl‑D‑glucosamine Based Fully Branched Tetrasaccharide, a Mimetic of the Endogenous Ligand for CD69, Activates CD69+ Killer Lymphocytes upon Dimerization via a Hydrophilic Flexible Linker Anna Kovalová, Miroslav Ledvina, David Šaman, Daniel Zyka, Monika Kubíčková, Lukás ̌ Ž ídek, Vladimír Sklenár,̌ Petr Pompach, Daniel Kavan, Jan Bílý, Ondřej Vaněk, Zuzana Kubínková, Martina Libigerová, Ljubina Ivanová, Mária Antolíková, Hynek Mrázek, Daniel Rozbeský, Kateřina Hofbauerová, Vladimír Křen, and Karel Bezouška* Journal of Medicinal Chemistry 2010, 53, 4050−4065. DOI: 10.1021/jm100055b The authors retract this article, as it was found that experiments describing binding of natural killer cell receptors to carbohydrate ligands could not be repeated and the identity of the proteins used in the experiments cannot be guaranteed. Authors who were reached support the retraction of this paper. Evidence of scientific misconduct on the part of Karel Bezouška has been found by the joint Ethical Committee established by the Institute of Microbiology of the Academy of Sciences of the Czech Republic and the Faculty of Science at the Charles University in Prague. The authors emphasize, however, that the publication contains accurate data in the section entitled “Chemistry” and in the sections on the synthesis of linear and branched oligosaccharides in the article as well as in the related Supporting Information. The structures of the synthesized compounds were fully characterized by physical methods that are standardly used in the saccharide chemistry, i.e., by NMR spectroscopy, MS spectrometry, and elemental analysis. The authors apologize to all affected parties.
Published: June 5, 2014 © 2014 American Chemical Society
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dx.doi.org/10.1021/jm5007726 | J. Med. Chem. 2014, 57, 5477−5477
