Book Review pubs.acs.org/jnp
Review of Design of Precursors for Sustainable Chemistry and postdoctoral researchers who have a basic knowledge of physics, chemistry, biology, and materials science. This chapter is divided into three sections: Section 1 is a discussion about the creation of protein, peptide, and small-molecule linkerbased bioinspired electrodes and the characterization by spectroscopy, microscopy, and cyclic voltammetry. Section 2 is the mechanism of O2 reduction by these electrodes including the roles of axial ligands and second sphere residues on the rates and selectivity. Section 3 is a discussion on the electron transfer properties of iron porphyrin complexes having different axial ligands and second sphere hydrogen-bonding interactions. The studies reviewed in this chapter can be used to design catalysts with improved properties that can be used in a variety of challenging chemical transformations. Proton exchange membrane fuel cells (PEMFCs) are an important class of clean and efficient renewable energy. They have been applied to a variety of important fields such as in the automobile industry. The problems with PEMFCs are as follows: (1) the high cost of production due to use of the expensive metal platinum, a noble metal with limited reserves on earth; (2) the moderate or low activity and durability. Therefore, huge efforts have been devoted to identify a nonnoble metal that is suitable for mass production and commercialization with reasonable cost and durability. Drs. Zihui Zhai, Chexi Qiu, and Yujiang Song (Dalian University of Technology) contributed a chapter (#209) entitled “Metallomacrocycles for the Creation of Non-Noble Metal and Noble Metal Electrocatalysts toward Oxygen Reduction Reactions (ORR)”. This chapter (#209) reviews the syntheses of non-noble metal and noble metal electrocatalysts. This book chapter can be used for training graduate students and postdoctoral researchers who have a basic knowledge of physics, chemistry, biology, and materials science. This chapter is divided into two sections: Section 1 is entitled Syntheses of Non-Noble Metal Electrocatalysts toward ORR Using Metalomacrocycles. Section 2 is entitled Light-Controlled Syntheses of Noble Metal ORR Electrocatalysts Using Photocatalytically Active Metalomacrocycles. The studies reviewed in this chapter represent the most promising technologies for the production of clean energy. Cancer remains one of the most challenging diseases with a very low cure rate due to lack of specificity. One way to improve specificity is to deliver a drug to the target tissue through advanced delivery systems or use a drug with high specificity. In the past 10 years, macromolecular therapeutics such as monoclonal antibodies are becoming increasingly attractive due to the high specificity and low toxicity. However, most macromolecular therapeutics have their therapeutic target on the surface of cells due to their inability to penetrate the cell membrane, which limits the use of macromolecular therapeutics with intracellular targets. Therefore, the research of intracellular delivery of macromolecular therapeutics has intensified. Drs. Kristian Berg and Pal Kristian Selbo (Oslo University Hospital)
Design of Precursors for Sustainable Chemistry. By Karl M. Kadish (University of Houston, USA), Kevin M. Smith (Louisiana State University, USA), and Roger Guilard (University of Bourgogne, France). World Scientific Publishing Co. Pte. Ltd., Singapore. 2016. 315 pp. $1850.00 ISBN 978981-3143-52-4 (set); ISBN 978-981-3143-57-9 (Vol. 43).
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ustainable chemistry (or green chemistry) has created a new paradigm in the development of molecules. The subject matter has been reviewed by many books and journal articles, but none of them specifically covered the importance and innovation of sustainable chemistry in the synthesis of porphyrins, which are a group of heterocyclic macrocycle organic compounds that have important roles in medicine, biomimetic catalysis, molecular electronics, and organic geochemistry. This book offers an in-depth coverage of the role of sustainable chemistry in the synthesis of porphyrins. In spite of the many favorable properties of porphyrins, their synthesis has been considered to be nonsustainable due to the long synthetic route and low yields as well as the unfavorable environmental impact. Therefore, tremendous efforts have been made in the past decade to develop more sustainable and “greener” methods for the synthesis of porphyrins. Drs. Jean-Gerard and B. Andrioletti (Université Claude Bernard Lyon 1), and Drs. N. Kardos and M. Draye (Université Savoie Mont Blanc) contribute to the book “Design of Precursors for Sustainable Chemistry” a chapter (#207) entitled “Sustainable Approaches in the Syntheses and Uses of Porphyrin(oid)s”. This chapter (#207) reviews the sustainable methods for the syntheses and uses of porphyrins and can be used for training graduate students and postdoctoral researchers who have a background in organic chemistry, physical chemistry, and spectroscopy. This chapter is divided into two major sections: Section 1 is “Green” Syntheses of Porphyrins and Analogs, and Section 2 is Sustainable Catalytic Transformations. In Section 1, the authors review the three main approaches used in the green syntheses of porphyrins: (1) the synthesis in green solvents (water and ionic liquids); (2) solventless syntheses; and (3) microwave-promoted syntheses. In Section 2, the authors discuss the potential application of these methods to energy sectors such as green oxidation and water splitting with porphyrins. Heme proteins play a key role as catalysts in the transformation of chemicals under ambient conditions. Synthetic efforts have been made since the 1930s to make molecules/catalysts by mimicking the active site of natural enzymes (e.g., heme proteins). Despite the high activities, the rates and selectivities of these synthetic catalysts are significantly lower than that of the natural enzymes they mimic. Drs. Sohini Mukherjee, Kushal Sengupta, Sabyasachi Bandyopadhay, and Abhishek Dey (Indian Association for the Cultivation of Science) contributed to this book a chapter (#208) entitled “Bio-inspired Electrodes”. This chapter (#208) reviews the bioinspired electrodes with synthetic models and can be used for training graduate students © 2017 American Chemical Society and American Society of Pharmacognosy
Published: May 1, 2017 1701
DOI: 10.1021/acs.jnatprod.7b00200 J. Nat. Prod. 2017, 80, 1701−1702
Journal of Natural Products
Book Review
contributed a chapter (#210) entitled “Photochemical Internalization (PCI)−A Technology for Intracellular Drug Delivery”. This chapter (#210) reviews photochemical internalization (PCI), a technology that can be applied to the delivery of macromolecular therapeutics to intracellular targets. This book chapter can be used to train graduate students and postdoctoral researchers who have a background in pharmaceutical science with an emphasis on physical chemistry, formulation, and drug delivery. This chapter is divided into two sections: Section 1 is entitled Photosensitizers for Use in PCI, and Section 2 is entitled The Use of PCI to Stimulate Intracellular Delivery. The advanced delivery method utilizing PCI is a promising technology for the delivery of protein drugs to an intracellular target for the treatment of various diseases. I highly recommend this book as an addition to any personal collection and to university libraries.
Jianjun Chen
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College of Pharmacy, Chicago State University, Chicago, Illinois, United States
AUTHOR INFORMATION
Notes
The author declares no competing financial interest.
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DOI: 10.1021/acs.jnatprod.7b00200 J. Nat. Prod. 2017, 80, 1701−1702
