Book Review pubs.acs.org/jnp
Review of Problems in Organic Structure Determination. A Practical Approach to NMR Spectroscopy Problems in Organic Structure Determination. A Practical Approach to NMR Spectroscopy. By Roger G. Linington (Simon Fraser University), Philip G. Williams (University of Hawaii), and John B. MacMillan (University of Texas Southwestern Medical Center). CRC Press/Taylor & Francis Group, Boca Raton, FL. 2016. 755 pp. 21 × 28 cm. $119.95. ISBN 978-1-4987-1962-9.
recommend this monograph as an addition to any personal collection and to university libraries.
H. Liva Rakotondraibe
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AUTHOR INFORMATION
Notes
The author declares no competing financial interest.
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uclear magnetic resonance spectroscopy (NMR) is a useful technique in the structure determination of synthetic and natural product compounds such as terpenoids, alkaloids, aromatic compounds, polyketides, peptides, and proteins. With the increasing development of extremely sensitive high-field NMR spectrometers (e.g., 900 MHz equipped with optimized probes and pulse sequences), microgram-scale samples can be identified structurally in a short period of time. Interpretation of 1D- and 2D-NMR spectra is, however, always a challenge, not only for students at all levels but also for professionals dealing with structure determination. NMR covers a wide range of scientific areas from physics to medicine, and no single monograph can cover all of its aspects. Drs. Linington, Williams, and MacMillan provide excellent materials for NMR training through a problem-based learning approach in their new book entitled Problems in Organic Structure Determination, A Practical Approach to NMR Spectroscopy. This book provides NMRbased problems in organic chemical structure elucidation and can be used in undergraduate and graduate student courses as well as by postdoctoral scientists who already have a basic knowledge of the structure elucidation of organic compounds. The book is mostly oriented toward natural product, synthetic, and analytical chemists working on structure elucidation of simple and complex small molecules. With the 130 NMR-based problems divided into six major sections (i.e., Sections 1 and 2: structure confirmation for simple and complex molecules, Sections 3 and 4: determination of unknown structures for simple and complex molecules, Section 5: determination of relative configurations using NMR methods, and Section 6: complex unknown natural product structure determination), the authors offer exercises to help users read and understand NMR data that can be obtained from 1D- and 2D-NMR spectra. To help readers, most of the problems are accompanied by detailed explanations, hints, and/or technical notes in their answer keys. In addition, all of the answers and answer keys can be downloaded from the publisher’s Web site. Also, for use as take-home exam questions and homework problems, this book is supplemented with a number of electronic resources including a complete set of original free induction decays (FIDs) for all compounds and complete layouts for all selected complex natural product problems. In summary, this informative NMR-based structure elucidation monograph covers most of the NMR tricks that can assist students and professionals solve structures of simple and complex synthetic and natural product molecules. I highly © XXXX American Chemical Society and American Society of Pharmacognosy
The Ohio State University, Columbus, Ohio, United States
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DOI: 10.1021/acs.jnatprod.6b00518 J. Nat. Prod. XXXX, XXX, XXX−XXX
