Anandan Palani,, Sherry Shapiro,, Hubert Josien,, Thomas Bara,, John W. Clader,, William J. Greenlee,, Kathleen Cox,, Julie M. Strizki, and, Bahige M...
The chemokine receptor CCR5 plays an important role in inflammatory and autoimmune disorders as .... potent CCR5 antagonist exhibiting IC50 values of 2.0,.
Aug 31, 2001 - Synthesis of14C-labeled piperidines and application to synthesis of [14C]SCH 351125, a CCR5 receptor antagonist. Sumei Ren , Paul McNamara ... Duncan Armour , Marcel J. de Groot , Martin Edwards , Manos Perros , David A. Price , Blanda
Jan 25, 2012 - ... Krystyna Vocadlo , Danielle Guay , Susan Nan , Helen Yee , Jason ... Veronique Bodart , Rebecca Wong , Simon Fricker , and Dominique ...
Jan 25, 2012 - A series of CCR5 antagonists representing the thiophene-3-yl-methyl ureas were designed that met the pharmacological criteria for HIV-1 inhibition and mitigated a human ether-a-go-go related gene (hERG) inhibition liability. Reducing l
Genzyme Corporation, 153 Second Avenue, Waltham, Massachusetts 02451, ... Anormed Inc., 200-20353 64th Avenue, Langley, British Columbia, V2Y 1N5 ...
Jan 25, 2012 - Design of Substituted Imidazolidinylpiperidinylbenzoic Acids as Chemokine Receptor 5 Antagonists: Potent Inhibitors of R5 HIV-1 Replication.
Jan 25, 2012 - Anormed Inc., 200-20353 64th Avenue, Langley, British Columbia, V2Y 1N5 Canada. § Rega Institute for Medical Research, Katholieke ...
May 12, 2017 - Interestingly, only 9 was found to be effective in suppressing body weight gain relative to control in a diet-induced obese dog model, suggesting ...
... Alan D. Neubertâ , Paul Szklennikâ , Vivienne Tedescoâ¡, James Thompsonâ¡, David Truongâ¡, Qing Yangâ¡, Brian K. Hubbardâ¡, and Michael H. Serrano-Wuâ .
May 12, 2017 - â Global Discovery Chemistry, â¡Cardiovascular and Metabolism, â¥PK Sciences, and §Translational Medicine, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, Massachusetts 02139, United States. J. Med. C
Anandan Palani,, Sherry Shapiro,, Hubert Josien,, Thomas Bara,, John W. Clader,, William J. Greenlee,, Kathleen Cox,, Julie M. Strizki, and, Bahige M. Baroudy.
