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A d d it ions and Corrections Synthesis, Absolute Configuration, and Analysis of Malathion, Malaoxon, and Isomalathion Enantiomers [Volume 6, Number 5, September/October 1993, pp 718-7231 CLIFFORDE. BERKMAN, CHARLESM. THOMPSON,’and SCOTT R. PERRIN Page 722. In Table I, row 7 in the body of the table, reading 3c [(1S,3S)-isomalathionl -57.6 (0.50) 56.92, should read 3c [(lR,3S)-isomalathion] -57.6 (0.50) 56.92.
Announcements Cytochrome P450 Joint Symposium: Structure, Function, Regulation, and Genetics The International Society for the Study of Xenobiotics and the Americai Society for Biochernistry a d Molecular Biology are sponsoring a symposium May 21 and 22, 1994, in Washington, DC, to recognize the scientific contributions of Dr. Ronald W. Estabrook. The scientific sessions will feature plenary lectures by major contributors to our understanding of the structure, function, regulation, and genetics of cytochromes P450. For more information, contact: Dr. Bettie Sue Masters, Department of Biochemistry, University of Texas Health Sciences Center, San Antonio, TX 78284-7760 (Tel: 210-567-6627; FAX: 210-5676984).
European ISSX Workshop: Toxicology of Industrial Compounds The 1994 European ISSX Workshop will be held June 12-15, 1994, in Schuluchsee, Germany. Representatives from industry, academia, research institutes, and regulatory authorities will be brought together to discuss the use and significanceof experimental toxicology in the safety assessment of industrial chemicals. Plenary lectures will review the major general topics of toxicokinetics, metabolism, mechanisms of toxicity, occupational safety, and regulation with respect to industrial chemicals. Mechanistic aspecb of toxicity as well as the toxicology of selected classes of industrial chemicals will be the subject of parallel afternoon sessions. Poster presentations and oral poster communications as well as a round table discussion on controversial mechanistic and regulatory issues in the safety assessment of industrial chemicals will round off this event. Participation will be limited. For further information please contact: 1994 European ISSX Workshop Secretariat, PO Box CH-4002, Basel, Switzerland (Tel: +4161 697 8320; FAX: +41 61 697 3679).
Sixth Congress on Nephrotoxicity and Nephrocarcinogenicity The Leiden/Amsterdam Center for Drug Research will be hosting the 6th Congress on Nephrotoxicity and Nephrocarcinogenicity September 21-24, 1994, in Noordwijkerhout, The Netherlands. This Symposium will cover various aspects of nephrotoxicity, including mechanisms of chemically induced nephrotoxicity, immunologically induced nephrotoxicity, toxicity after ischemia, wound repair, and nephrocarcinogenesis. For more information please contact: Symposium Secretariat, Mrs. F. J. Velthorst, LACDR, P.O. Box 9502,2300 RA Leiden, The Netherlands (Tel: +31 71 274 341; FAX: +31 71 274 277).
Sixth North American ISSX Meeting The International Society for the Study of Xenobiotics (ISSX) will be holding their 6th North American Meeting October 23-27,1994, at North Carolina State University in Raleigh, North Carolina. The meeting will begin with four half-day short courses on “Comparison of in Vitro and in Vivo Models for Studies of Drug Metabolism and Toxicity”; “Liquid Chromatography and Mass Spectrometry in the Study of Xenobiotics”; “Applications of Physiologically-Based Pharmacokinetic Models in Studies of Xenobiotic Metabolism”; and %DNA Expression Systems for Enzymes of Drug Metabolism: An Introduction to Methods and Applications”. Eleven symposium sessions are planned which will include the Second Rochester-Wurzburg Conference on Frontiers in Molecular Toxicology,
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organized by M. W. Anders and W. Dekant. Other symposium topics include “Human Enzymes in Xenobiotic Metabolism”, “In Vitro Techniques for the Study of Drug Metabolism”, “Emerging Techniques in Drug and Metabolite Analysis”, “Gene Regulation”, “Rational Approaches to Drug Development”, ”Cation Radicals in Drug Metabolism”, and “Delivery and Disposition of Peptides and Oligonucleotides-Current Status and Future Status”. For more information, contact: Dr. Ernest Hodgson, Department of Toxicology, North Carolina FAX 919-515-7169). State University, Box 7633,Raleigh, NC 27695-7633(Tel: 919-515-2274;
The Fifth International Symposium on Biological Reaotive Intermediates The Fifth International Symposium on Biological Reactive Intermediates will be held January 44,1995,in Munich, Germany. The Symposium will feature a series of platform presentations, with ample time for discussion, describing advances in our understanding of fundamental mechanisms of toxicity and carcinogenesis. A series of poster-discussion sessionsand a final day workshop devoted to coupling data from mechanistic toxicology with current research in PBPK, biomarkers, and the process of human health risk assessment are also planned. Symposium topics will include the following: Generation of biological reactive intermediates; Cellular damage; Role of reactive intermediates and redox state on GSH transferase and quinone reductase; Nitric oxide; Effects on specific organs; Endogenous reactive intermediates; Conjugation and organ-organ interactions; Mathematical modeling of bioactivation; Linking mechanistic studies to risk assessment. The posterdiscussion session topica will include the following: Human cytochrome P450s,xenobioticmetabolism, and polymorphisms; Oxidative stress and gene expression; Molecular epidemiology, biomarkers, and risk assessment.
For further information, please contact: Dr. R. Snyder, EOHSI, 681 Frelinghuysen Rd., P.O. Box 1179,Piscataway, NJ 08855-1179(FAX 908-932-0119).
Meeting Calendar July 4-9, 1994
Eighth International Congressof Pesticide Chemistry [Chern.Res. Toxicol. 7 (11, 119,19941.
September 25-30, 1994 International Symposium on Human Health and Environment: “Mechanisms of Toxicity and Biomarkers To Assess Adverse Effects of Chemicals” [Chern. Res. Toxicol. 7 (l),119,19941.
