© Copyright 2007 by the American Chemical Society
Volume 46, Number 2
January 16, 2007
Current Topics Solution NMR of Large Molecules and Assemblies† Mark P. Foster,*,‡,§ Craig A. McElroy,‡ and Carlos D. Amero§ Department of Biochemistry and Biophysics Program, The Ohio State UniVersity, 484 West 12th AVenue, Columbus, Ohio 43210 ReceiVed October 12, 2006; ReVised Manuscript ReceiVed NoVember 15, 2006 ABSTRACT: Solution NMR spectroscopy represents a powerful tool for examining the structure and function of biological macromolecules. The advent of multidimensional (2D-4D) NMR, together with the widespread use of uniform isotopic labeling of proteins and RNA with the NMR-active isotopes, 15N and 13C, opened the door to detailed analyses of macromolecular structure, dynamics, and interactions of smaller macromolecules (
