Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin

Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin

ACS eBooks; C&EN Global Enterprise .... The unusual, major groove-aligned structure of the adduct 5 may account for the low cytotoxicity of 2,7-DAM. View: PDF | PDF w/ Links | Full Text HTML .... Properties of New Heterocyclic Derivatives of 1,3-Diaz


Aug 9, 2001 - Calcutta, India. 1 Abbreviations: MC, mitomycin C; 2,7-DAM, 2,7-diaminomitosene; ..... other than those centered about the [M]G4 adduct site in.


nan Subramaniam, Manuel M. Paz, Gopinatha Suresh Ku- mar, Arunangshu Das, Yolanda Palom, Cristina C. Clement,. Dinshaw J. Patel, and Maria Tomasz*, ...


2,7-Diaminomitosene (2,7-DAM), the major metabolite of the antitumor antibiotic mitomycin C, forms DNA adducts in tumor cells. 2,7-DAM was reacted with the ...

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Sep 1, 1997 - P.O. Box 124, 22100 Lund, Sweden, and Department of Soil Sciences and Plant .... ri is the distance between an atom i and the metal ion, and.

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Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin

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