Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin

Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin

ACS eBooks; C&EN Global Enterprise .... The unusual, major groove-aligned structure of the adduct 5 may account for the low cytotoxicity of 2,7-DAM. View: PDF | PDF w/ Links | Full Text HTML .... Properties of New Heterocyclic Derivatives of 1,3-Diaz


Aug 9, 2001 - Calcutta, India. 1 Abbreviations: MC, mitomycin C; 2,7-DAM, 2,7-diaminomitosene; ..... other than those centered about the [M]G4 adduct site in.


2,7-Diaminomitosene (2,7-DAM), the major metabolite of the antitumor antibiotic mitomycin C, forms DNA adducts in tumor cells. 2,7-DAM was reacted with the ...


Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin C Metabolite 2,7-Diaminomitosene and DNA. Basis of Sequence Selectivity,.

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Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin

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