Special Feature Section: Polymorphism & Crystallization 2015

Tsou, Shultz, Andreani, Ball, Brunskill, Balsells, Cohen, DaSilva, Li, Reamer, de Lera Ruiz, Variankaval, Varsolona, Yasuda, and York. 2015 19 (12), p...
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Special Feature Section: Polymorphism & Crystallization 2015

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olymorphism and the crystallization and other downstream processes that produce polymorphs, solvates, hydrates, and cocrystals are of vital importance in industry, particularly in the manufacture of high added-value products with extremely tight specifications, such as pharmaceuticals, agrochemicals, color chemicals, and chemicals for electronics. Crystallization is one of the most important unit operations for impurity removal so control of the crystallization process to produce the desired crystal form with the appropriate stability and properties for further formulation is a topic of considerable interest to industry. Control of these complex processes is not possible without a fundamental understanding of the detailed theory and mechanisms involved, and academic studies often lead to practical consequences.Thus, collaborations between academia and industry are particularly valuable and often yield fruitful results. This special feature section of Organic Process Research & Development (OPR&D) is the sixth we have published on the subject of Polymorphism and Crystallization, the last being in 2013. The issue contains 13 papers with a higher proportion than in previous special features coming from the academic environment. The multidisciplinary nature of many of the papers is to be welcomed, and I hope that these papers stimulate the reader to produce new ideas and develop innovative processes in the future or simply educate the readers who may not be so familiar with the intricacies and challenges of crystallization of complex molecules. I am pleased that OPR&D has received so many papers from such a wide variety of institutions and departments, and I thank all those who have contributed to this special section.

Trevor Laird*



Trevor Laird Associates Ltd., Waldron, U.K.

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Corresponding Author

*E-mail: trevor@scientificupdate.co.uk. Notes

Views expressed in this editorial are those of the author and not necessarily the views of the ACS.

Special Issue: Polymorphism & Crystallization 2015

© XXXX American Chemical Society

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DOI: 10.1021/acs.oprd.5b00398 Org. Process Res. Dev. XXXX, XXX, XXX−XXX