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J. Med. Chem. 1998, 41, 2100-2110
Specific and Irreversible Cyclopeptide Inhibitors of Dipeptidyl Peptidase IV Activity of the T-Cell Activation Antigen CD26 Coralie Nguyen,† Julia` Blanco,‡ Jean-Paul Mazaleyrat,† Bernard Krust,‡ Christian Callebaut,‡ Etienne Jacotot,‡ Ara G. Hovanessian,‡ and Michel Wakselman*,† SIRCOB, Universite´ de Versailles, Baˆ timent Lavoisier, 45 avenue des Etats Unis, F-78000 Versailles, France, and Unite´ de Virologie et Immunologie Cellulaire, ERS 572 CNRS, Institut Pasteur, 28 rue du Dr. Roux, F-75724 Paris Cedex 15, France Received September 26, 1997
The dipeptidyl peptidase IV (DPP IV) activity of CD26 is characterized by its post-prolinecleaving capacity that plays an important but not yet understood role in biological processes. Here we describe a new family of specific and irreversible inhibitors of this enzyme. Taking into account the substrate specificity of DPP IV for P2-P1>
