Pavel Kubát, Kamil Lang, Petr CÃgler, Milan KožÃÅ¡ek, Pavel MatÄjÃÄek, Pavel Janda, ZdenÄk Zelinger, Karel Procházka, and VladimÃr Král. Th...
Fatiah Issa , Michael Kassiou , and Louis M. Rendina. Chemical Reviews 2011 111 ... Stephen B. Kahl, John J. Schaeck, and Myoung-Seo Koo. The Journal of ...
Jul 24, 2013 - A nonspecific exopeptidase, aminopeptidase N (APN), is inhibited sequence-specifically by a synthetic host, cucurbit[7]uril (Q7), which binds with high affinity and specificity to N-terminal phenylalanine (Phe) and 4-(aminomethyl)pheny
Publication Date (Web): July 24, 2013 ... A nonspecific exopeptidase, aminopeptidase N (APN), is inhibited sequence-specifically by a synthetic host, cucurbit[7]uril (Q7), which binds with high affinity and specificity to .... Drug Delivery by Contro
Jul 24, 2013 - Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, ...
Molecular Biology Research Section, Wyeth-Ayerst Research, Lederle Laboratories, Pearl RiVer, New York 10965. ReceiVed December 19, 1995; ReVised ...
of human cytomegalovirus UL80 protease. Two types of inhibited protease were observed, depending on inhibitor concentration. At high concentrations ...
A symmetrically substituted disulfide compound, CL13933, was identified as a potent inhibitor of human cytomegalovirus UL80 protease. Two types of inhibited ...
Joe Magrath, and Robert H. Abeles. J. Med. Chem. ... Wendy A. Loughlin , Joel D. A. Tyndall , Matthew P. Glenn , Timothy A. Hill , and David P. Fairlie. Chemical ...
De Wittelaan L11 B3, B-2800 Mechelen, Belgium, and Center for Molecular Design, Janssen Pharmaceutica NV, Antwerpsesteenweg 37, B-2350 Vosselaar, ...
Mar 13, 2013 - Approaches to 1 require the optimization of both pep- tidoglycan and X. One ... and Bacillus subtilis PBP4a were expressed and purified as described ... (AB q, J = 13.5 Hz, 4H), 5.26 (AB q, J = 3 Hz, 2H), 5.20, 5.32. (AB q, J = 12 Hz,
3426
J.Med. Chem. 1992,35,3426-3428
Specific Inhibition of HIV-1 Protease by Boronated Porphyrins The rapid spread of human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), throughout the world has prompted an intense search for antiretroviral therapeutics. An analysis of nonpeptide compounds with useful pharmacological properties led us to test the ability of porphyrins to inhibit HIV protease (HIV PR). Determination of the IC,250 75 8 OCO-p- [ (CH3),N]benzoyl 9 m-OCOBloH11C2 H2 12 11 250 >150 10 OCOC6H5 H2 14 30 250 >lo0 11 OCO(0-naphthoyl) H2 14 23 250 >150 12 OH H2 280 480 250 >200 Protoporphyrin IX 300 500 200 U-75875“
