Stable Preformed Chiral Palladium Catalysts for the One-Pot

ORGANIC LETTERS

Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

2009 Vol. 11, No. 2 265-268

Laura Rubio-Pe´rez,* F. Javier Pe´rez-Flores, Pankaj Sharma, Luis Velasco, and Armando Cabrera Instituto de Quı´mica, UniVersidad Nacional Auto´noma de Me´xico, Circuito Exterior, Ciudad UniVersitaria, Me´xico, 04510, D. F., Me´xico [email protected] Received October 8, 2008

ABSTRACT

The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (