Synthesis and antifertility activity of 3, 9-dihydroxy-5, 6, 6a. alpha., 6b

octahydrodibenzo[a,g]biphenylene, a structural relative of diethylstilbestrol. P. H. Ruehle, C. E. Browne, E. H. Vickery, N. R. Beller, E. J. Eisenbra...
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J . Med. Chem. 1980,23, 1410-1414

1410

Table 11. Antihypertensive Activity of Compounds in Unanesthetized Renal Hypertensive Dogs (RHD) max A in BPa dose, compd mg/kg PO day 1 day 2 day 3 day 4 -13 i 16.1 -6 i 13.6 MBP: -32 i 10.8 -14 i 16.2 22 100 HR: + 7 4 t 12.5* + 6 1 i 13.2 + 5 2 i 13.6 + 4 8 i 28.6 -56 i 5.0* -51 i 5.2* MBP: - 3 O i 8.5 -46 2 18.4 34 100 HR: + 3 5 + 12.7 + 7 8 i 17.2 + 5 1 i 13.5 t 4 4 i 10.1* 54 100 MBP: -15 i 6.8 -9 i 1.7* -4 t 1.8 HR: t 1 6 i 10.6 +11i 12.7 + 1 1 f 12.7 55 100 MBP: -21 i 16.0 -25 i 7.5 HR: + 1 c 8.1 t 3 9 + 2.3 65 100 MBP: -69 i 13.7* -41 i 0.3* -49 i 2.9* -48 i 9.0* HR: + 3 7 * 10.7 + 6 0 i 13.1* + 5 2 t 18.6 + 4 1 i 37.0 71 100 MBP: t11 i 6.1 -67 i 5.2* -40 i 15.5 HR: + 2 0 i 8.0 + 1 1 2 i 22.0* + l o 7 i 8.1* fusaric acid 60 MBP: - 5 O i 7 -45 * 1 2 -30 i 7 HR: + 3 2 i 18 +35 i 17 +33+ 5 a Values are mean i SE;an asterisk indicates p