Synthesis and Antiparasitic and Antitumor Activity of 2, 4-Diamino-6

J. Med. Chem. 2002, 45, 1957-1958

Additions and Corrections 1997, Volume 40 Andre Rosowsky,* Andrew T. Papoulis, and Sherry F. Queener: 2,4-Diaminothieno[2,3-d]pyrimidine Lipophilic Antifolates as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase. Page 3696, Table 1. The IC50 value for PTX (4) against rat liver DHFR should read 0.0015 µM instead of 0.015 µM. The selectivity ratios for P. carinii and T. gondii relative to rat liver DHFR, however, were correctly calculated from the lower IC50 value. JM020059B 10.1021/jm020059b Published on Web 03/14/2002

1998, Volume 41 Andre Rosowsky,* Andrew Papoulis, and Sherry F. Queener: 2,4-Diamino-6,7-dihydro-5Hcyclopenta[d]pyrimidine Analogues of Trimethoprim as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase. Page 916, Table 1. The IC50 value for PTX (4) against rat liver DHFR should read 0.0015 µM instead of 0.015 µM. The selectivity ratios for P. carinii and T. gondii relative to rat liver DHFR, however, were correctly calculated from the lower IC50 value. JM020060A 10.1021/jm020060a Published on Web 03/14/2002

1999, Volume 42 Andre Rosowsky,* Andrew Papoulis, Ronald A. Forsch, and Sherry F. Queener: Synthesis and Antiparasitic and Antitumor Activity of 2,4-Diamino6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline Analogues of Piritrexim. Page 1011, Table 2. The IC50 value for PTX (6) against rat liver DHFR should read 0.0015 µM instead of 0.015 µM. The selectivity ratios for P. carinii and T. gondii relative to rat liver DHFR, however, were correctly calculated from the lower IC50 value. JM0200613 10.1021/jm0200613 Published on Web 03/14/2002

1957

1958 Journal of Medicinal Chemistry, 2002, Vol. 45, No. 9

2000, Volume 43 Rory P. Remmel: Drug Metabolism Databases and High-Throughput Testing During Drug Design and Development. Page 3197. Under Book Reviews, in the title paragraph, line 3, and in the first paragraph, line 4, Paul W. Ehrhardt is misspelled; the correct spelling is Paul W. Erhardt. JM000383B 10.1021/jm000383b Published on Web 04/25/2002

Additions and Corrections