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Oct 17, 2016 - The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine scaffold. Twenty-one ...


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Oct 17, 2016 - Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road ...


Oct 17, 2016 - A series of 3,6-diaryl-[1,2,4]triazolo[4,3-b]pyridazines were designed as a class of vinylogous CA-4 analogues. The easily isomerized (Z,E)-butadiene linker of vinylogous CA-4 was replaced by a rigid [1,2,4]triazolo[4,3-b]pyridazine sc

Synthesis and Bioevaluation of Î7-5-Desaturase Inhibitors, an

leaving group (L) which was thought to be obtainable from a C-6R .... between the C-6 proton and the C-19 methyl group of ..... To 5R-cyano-7,22(E)-ergo-.

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Kristen Skruber, Kelvin J. Chaplin, and Otto Phanstiel IV. University of Central Florida, College of Medicine, 12722 Research Parkway, Orlando, Florida 32826, United States. J. Med. Chem. , 2017, 60 (20), pp 8606â8619. DOI: 10.1021/acs.jmedchem.7b0


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Page 5099. The acknowledgement section should state that this work was supported by Sterling-Win- throp Pharmaceuticals. JM970352P. 3706. J. Med. Chem.

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