Synthesis and Reaction of Potential Alternate Substrates and

Jortrnal of Natural Prodwts Vol. 56, NO.8,pp. 1373-1396, August 1993

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SYNTHESIS AND REACTION OF POTENTIAL ALTERNATE SUBSTRATES AND MECHANISM-BASED INHIBITORS OF CLAVAMINATE SYNTHASE' DIRKIWATA-RELIIT, h I T BASAK, U S A s. SILVERMAN, CHRISTOPHER A. ENGLE,and CRAIGA. TOWNSEND* Department ofchemistty, TheJohns Hopkins University, Baltimore, Maryland 21 21 8 hSTRACT.