Synthesis of Corticosteroids from Marine Sources. Sir: Corticosteroids are generally synthesized either from plant sapogenins (e.g., diosgenin, hecogenin) or ...
Identification of Trp-371 as the main site of specific photoaffinity labeling of corticosteroid binding globulin using .DELTA.6 derivatives of cortisol, corticosterone, ...
Steroids. V.1 The Synthesis of Adrenal Corticosteroids and Analogs from ... For a more comprehensive list of citations to this article, users are encouraged to ...
David Gould, Elliot L. Shapiro, Hersfel L. Herzog, Margaret J. Gentles, E. B. Hershberg, William Charney, Marilyn Gilmore, Sibylle Tolksdorf, Milton Eisler, ...
several lactones was evaluated. Steroidal enol lactones of the type (II) were required for studies concerning the degradation of corticosteroids.3-6. The Baeyer-.
Synthesis of Adrenal Corticosteroids and Analogs. 4081. [Contribution from thb. Research Laboratories of Syntbx, S. A.] Steroids. V.1. The Synthesis of Adrenal ...
V.1 The Synthesis of Adrenal Corticosteroids and Analogs from Allopregnan-3β-o1-20-one. G. Rosenkranz, J. Pataki, St. Kaufmann, J. Berlin, Carl Djerassi.
Degradation of Corticosteroids. VII. The Synthesis of 7-Membered Ring-A Enol-Lactones. E. Caspi, Y. W. Chang, and R. I. Dorfman. J. Med. Chem. , 1962, 5 (4), ...
Sep 1, 1987 - Citation data is made available by participants in CrossRef's Cited-by Linking service. For a more comprehensive list of citations to this article, ...
Carmen Festa , Simona De Marino , Maria Valeria D'Auria , Giuseppe Bifulco , Barbara Renga , Stefano Fiorucci , Sylvain Petek , and Angela Zampella.
628 RO.
+ HOR e [RO---H---OR] e ROH + .OR
It
intermediate or transition state
[HORln
It [ROHln
We infer that iminoxy radicals form hydrogen bonds more reluctantly than nitroxidesZO(or peroxy radicals21) from the observations that the a N value of 1 in isopentane is within 1 of its value in ethanol and that the visible spectra of 1 in cyclohexane and in ethanol are virtually identical. Substantial changes of these properties in nitroxides have been associated with the formation of hydrogen bond^.^^^^^ Reluctance to form a hydrogen-bonded intermediate probably explains the high activation energy and low rate constant for the 1 1-H reaction. The large value of KeqZ5’for the 1 2c-H system cannot be accounted for on this basis. We believe that it is due mainly to severe intramolecular repulsive interactions (principally Rl-R2 and R2-O) in the oxime 1-H that are lessened by a more relaxed geometry in 1. Evidence supporting this suggestion will be presented later. The present results appear to be relevant to the potential use of stable iminoxy radicals as spin l a b e l ~ ~ ~and .*5 in other studies of local molecular environment. 26-2?8 Acknowledgment. We gratefully acknowledge receipt of a generous sample of di-tert-butylketimine from Dr. H. D . Hartzler (Du Pont).
