236
J . Med. Chem. 1989,32, 236-243
Table XIII. Percent Inhibition of ADP-Induced Platelet Aggregation Data for Compounds 1 and 58 % inhibn expt concn of compda PGEl 1 1 32 94 82 10 56 38 26 3.2 29 1.0 2 32 90 10 85 28 1 3.2 62 27 1.0 72 3 32 37 10 14 3.2 1.0 OThe concentration of PGE, is in ng/mL; the concentration and 58 is in fig, mL.
58
Ex Vivo Studies. Compounds were dissolved in Emulphor/ethanol/Tyrodes and were administered gastrically to rats and guinea pigs via gavage. A t 2 h after drug or placebo administration, blood samples were drawn from all animals as described previously. P R P was prepared and aggregation experiments were conducted as previously described. Activity was determined by demonstration of a p value of
