Synthesis of Ortho-Palladated Phenol Derivatives ... - ACS Publications

Postfach 3329, 38023 Braunschweig, Germany. Axel K. Fischer. Institut fu¨r Chemie, Universita¨t Magdeburg, Universita¨tsplatz 2, 37106 Magdeburg, G...
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Organometallics 2001, 20, 2704-2715

Synthesis of Ortho-Palladated Phenol Derivatives. Study of Their Reactivity with Carbon Monoxide and Isonitriles Jose´ Vicente,*,† Jose´-Antonio Abad,*,‡ and Walter Fo¨rtsch Grupo de Quı´mica Organometa´ lica, Departamento de Quı´mica Inorga´ nica, Facultad de Quı´mica, Universidad de Murcia, Aptdo. 4021, E-30071 Murcia, Spain

Peter G. Jones*,§ Institut fu¨ r Anorganische und Analytische Chemie, Technische Universita¨ t Braunschweig, Postfach 3329, 38023 Braunschweig, Germany

Axel K. Fischer Institut fu¨ r Chemie, Universita¨ t Magdeburg, Universita¨ tsplatz 2, 37106 Magdeburg, Germany Received January 30, 2001

The reaction of 2-ROC6H4I with [Pd2(dba)3]‚dba (“Pd(dba)2”; dba ) dibenzylideneacetone) in the presence of the appropriate ligand results in the formation of the arylpalladium complexes trans-[Pd(C6H4OR-2)I(PPh3)2] (R ) H (1a), C(O)Me (1b), C(O)CHdCH2 (1c)) and [Pd(C6H4OR-2)I(bpy)] (bpy ) 2,2′-bipyridine; R ) H (2a), C(O)Me (2b)). Complexes 1b and 1c react with bpy in the presence of Tl(OTf) (OTf ) OSO2CF3) to give the cationic species [Pd(C6H4OR-2)(bpy)(PPh3)]OTf (R ) C(O)Me (3b), C(O)CHdCH2 (3c)). Complex 1a reacts with carbon monoxide, yielding the insertion complex trans-[Pd{C(O)C6H4OH-2}I(PPh3)2] (4a). Complexes 2a and 2b can also be carbonylated to give [Pd{C(O)C6H4OR-2}I(bpy)] (R ) H (5a), C(O)Me (5b)). Complex 4a reacts with bpy and Tl(OTf), giving [Pd{C(O)C6H4OH2}(bpy)(PPh3)]OTf (6a). The reaction of 2-ROC6H4I with Pd(dba)2 and isonitriles R′NC gives rise to the complexes trans-[Pd{C(dNR′)C6H4OR-2}I(CNR′)2] (R ) H, R′ ) Xy ) 2,6dimethylphenyl) (7a), R′ ) tBu (7a*); R ) C(O)Me, R′ ) Xy (7b), R′ ) tBu (7b*)). Complexes 7a and 7b* can also be prepared by ligand displacement from 2a and 2b and XyNC and tBuNC, respectively. Complexes 2a and 2b react with R′NC (1:1) to give [Pd{C(dNR′)C H 6 4 OR-2}I(bpy)] (R ) H, R′ ) Xy (8a), R′ ) tBu (8a*); R ) C(O)Me, R′ ) Xy (8b)). Complex 7a reacts with bpy in the presence of Tl(OTf), yielding [Pd{C(dNR′)C6H4OH-2}(CNR′)(bpy)]OTf (9a). Reaction of 5a with R′NC gives trans-[Pd{C(O)C6H4OH-2}I(CNR′)2] (R′ ) Xy (10a), tBu (10a*)), which, in turn, react with further R′NC in the presence of Tl(OTf) to give [Pd{C(O)C6H4OH-2}(CNR′)3]OTf (R′ ) Xy (11a), tBu (11a*)). Finally, the reaction of 7a with Pd(OAc)2 results in the tetrameric [Pd{κ2(C,O)-µ2(O)-C(dNXy)C6H4O-2}(CNXy)]4 (12) and trans-[PdI2(CNXy)2]. Most of the reported aroyl (4-6, 10, 11) and iminoaroyl (7-9, 12) derivatives are new types of palladium complexes. The crystal structures of complexes 5a, 7a, 7b, 8b, 9a, and 12 have been determined by X-ray diffraction methods. The following scale of trans influence has been established: bpy < I < C(dNXy)C6H4OC(O)Me-2 ≈ C(dO)C6H4OH-2 < C(dNXy)C6H4OH-2. Introduction We have shown that (2-X-aryl)palladium complexes have interesting properties when X is a reactive substituent such as CHO, C(O)Me, C(O)NHR, NH2, NO2, CN, and CHdCH2.1-11 In this paper we report the †

E-mail: [email protected]; http://www.scc.um.es/gi/gqo/. E-mail: [email protected]. E-mail: [email protected]. (1) Vicente, J.; Abad, J. A.; Martı´nez-Viviente, E.; Ramı´rez de Arellano, M. C.; Jones, P. G. Organometallics 2000, 19, 752. (2) Vicente, J.; Abad, J. A.; Frankland, A. D.; Ramı´rez de Arellano, M. C. Chem. Eur. J. 1999, 5, 3067. (3) Vicente, J.; Abad, J. A.; Rink, B.; Herna´ndez, F.-S.; Ramı´rez de Arellano, M. C. Organometallics 1997, 16, 5269. (4) Vicente, J.; Abad, J. A.; Shaw, K. F.; Gil-Rubio, J.; Ramı´rez de Arellano, M. C.; Jones, P. G. Organometallics 1997, 16, 4557. ‡ §

synthesis of complexes with X ) OH, OC(O)Me, and OC(O)CHdCH2. These complexes seem to play an important role in some palladium-catalyzed processes, (5) Vicente, J.; Abad, J. A.; Frankland, A. D.; Ramı´rez de Arellano, M. C. Chem. Commun. 1997, 959. (6) Vicente, J.; Arcas, A.; Blasco, M. A.; Lozano, J.; Ramı´rez de Arellano, M. C. Organometallics 1998, 17, 5374. (7) Vicente, J.; Abad, J. A.; Gil-Rubio, J. Organometallics 1996, 15, 3509. (8) Vicente, J.; Abad, J. A.; Bergs, R.; Jones, P. G.; Ramı´rez de Arellano, M. C. Organometallics 1996, 15, 1422. (9) Vicente, J.; Abad, J. A.; Bergs, R.; Jones, P. G.; Bautista, D. J. Chem. Soc., Dalton Trans. 1995, 3093. (10) Vicente, J.; Abad, J. A.; Gil-Rubio, J.; Jones, P. G. Organometallics 1995, 14, 2677. (11) Vicente, J.; Abad, J. A.; Jones, P. G. Organometallics 1992, 11, 3512.

10.1021/om010074z CCC: $20.00 © 2001 American Chemical Society Publication on Web 05/26/2001

Ortho-Palladated Phenol Derivatives

e.g., in the formation of o-alkynylphenols, which are intermediates in the formation of benzofurans.12-14 Similarly, ortho-palladated O-substituted phenol derivatives may be catalytic intermediates in intramolecular cyclizations to give 4-methylcoumarin,15,16 1,3benzoxazepin-2-ones,17 or benzopyrans.18 However, as far as we are aware, ortho-palladated phenol or phenol ester derivatives have not yet been isolated; in this work, we report on the synthesis of these types of complexes and on their reactivity with carbon monoxide and isonitriles. The insertion of CO into the Pd-C bond, resulting in the formation of acylpalladium derivatives, constitutes a key step in the palladium-catalyzed carbonylation of organic substrates in laboratory synthesis and also in industrial processes.19-24 These CO insertions are also relevant in the palladium-catalyzed copolymerization of CO and unsaturated organic substrates.25-39 This is the reason for the extensive study of insertion reactions.21,40-44 However, most studies of insertion reac(12) Botta, M.; Summa, V.; Corelli, F.; Dipietro, G.; Lombardi, P. Tetrahedron: Asymmetry 1996, 7, 1263. (13) Arcadi, A.; Cacchi, S.; Delrosario, M.; Fabrizi, G.; Marinelli, F. J. Org. Chem. 1996, 61, 9280. (14) Lu¨tjens, H.; Scammells, P. J. Tetrahedron Lett. 1998, 39, 6581. (15) Catellani, M.; Chiusoli, G. P.; Fagnola, M. C.; Solari, G. Tetrahedron Lett. 1994, 35, 5919. (16) Catellani, M.; Chiusoli, G. P.; Marzolini, G.; Rossi, E. J. Organomet. Chem. 1996, 525, 65. (17) Bocelli, G.; Catellani, M.; Chiusoli, G. P.; Cugini, F.; Lasagni, B.; Mari, M. N. Inorg. Chim. Acta 1998, 270, 123. (18) So¨derberg, B. J.; Rector, S. R.; O’Neil, S. Tetrahedron Lett. 1999, 40, 3657. (19) Heck, R. F. Palladium Reagents in Organic Synthesis; Academic Press: New York, 1985. (20) Tsuji, J. Palladium Reagents and Catalysts, Wiley: Chichester, U.K., 1995. (21) Yamamoto, Y. Bull. Chem. Soc. Jpn. 1995, 68, 433. (22) Negishi, E.; Coperet, C.; Ma, S. M.; Mita, T.; Sugihara, T.; Tour, J. M. J. Am. Chem. Soc. 1996, 118, 5904. (23) Yamamoto, A. J. Chem. Soc., Dalton Trans. 1999, 1027. (24) Lin, Y. S.; Yamamoto, A. Organometallics 1998, 17, 3466. (25) Sen, A. Acc. Chem. Res. 1993, 26, 303. (26) van Asselt, R.; Gielens, E.; Ru¨lke, R. E.; Vrieze, K.; Elsevier, C. J. J. Am. Chem. Soc. 1994, 116, 977. (27) Markies, B. A.; Kruis, D.; Rietveld, M. H. P.; Verkerk, K. A. N.; Boersma, J.; Kooijman, H.; Lakin, M. T.; Spek, A. L.; van Koten, G. J. Am. Chem. Soc. 1995, 117, 5263. (28) Drent, E.; Budzelaar, P. H. M. Chem. Rev. 1996, 96, 663. (29) Abu-Surrah, A.; Rieger, B. Angew. Chem., Int. Ed. Engl. 1996, 35, 2475. (30) Koide, Y.; Bott, S. G.; Barron, A. R. Organometallics 1996, 15, 2213. (31) Nozaki, K.; Naomasa, S.; Tonomura, Y.; Yasutomi, M.; Takaya, H.; Hiyama, T.; Matsubara, T.; Koga, N. J. Am. Chem. Soc. 1997, 119, 12779. (32) Safir, A. L.; Novak, B. M. J. Am. Chem. Soc. 1998, 120, 643. (33) Mecking, S.; Johnson, L. K.; Wang, L.; Brookhart, M. J. Am. Chem. Soc. 1998, 120, 0. (34) Kacker, S.; Kim, J. S.; Sen, A. Angew. Chem., Int. Ed. 1998, 37, 7, 1251. (35) Carfagna, C.; Formica, M.; Gatti, G.; Musco, A.; Pierleoni, A. Chem. Commun. 1998, 1113. (36) Aeby, A.; Consiglio, G. J. Chem. Soc., Dalton Trans. 1999, 655. (37) Brinkmann, P. H. P.; Luinstra, G. A. J. Organomet. Chem. 1999, 572, 193. (38) Macchioni, A.; Bellachioma, G.; Cardaci, G.; Travaglia, M.; Zuccaccia, C.; Milani, B.; Corso, G.; Zangrando, E.; Mestroni, G.; Carfagna, C.; Formica, M. Organometallics 1999, 18, 3061. (39) Parlevliet, F. J.; Zuideveld, M. A.; Kiener, C.; Kooijman, H.; Spek, A. L.; Kamer, P. C. J.; van Leeuwen, P. W. N. M. Organometallics 1999, 18, 3394. (40) Yamamoto, A. J. Organomet. Chem. 1995, 500, 337. (41) Cavell, K. J. Coord. Chem. Rev. 1996, 155, 209. (42) Groen, J. H.; de Jong, B. J.; Ernsting, J. M.; van Leeuwen, P. W. N. M.; Vrieze, K.; Smeets, W. J. J.; Spek, A. L. J. Organomet. Chem. 1999, 573, 3 and references therein. (43) Gutierrez, E.; Nicasio, M. C.; Paneque, M.; Ruiz, C.; Salazar, V. J. Organomet. Chem. 1997, 549, 167.

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tions of CO into Pd-C bonds have been devoted to alkyl, mainly methyl, derivatives.24,40,43-50 Only mononuclear phenyl- or alkyl-substituted phenyl46,51-56 and dinuclear 1,4-phenylene and 4,4′-biphenyl57 palladium complexes have been carbonylated. The rates of reaction of a variety of trans-[Pd(Ar)X(PPh3)2] (Ar ) C6H4R-4, R ) H, NO2, Me, CN, CF3, OMe; X ) Cl, Br, I) complexes with CO have been studied, but the resulting complexes have not been isolated.58 We have isolated the first carbonylation products of functionalized arylpalladium(II) complexes, [Pd(C6H4NH2-2)I(bpy)] and [Pd(C6H4NH2-2)I(PR3)] (R ) Ph, C6H4Me-4).2,5 Norbornene,59,60 norbornadiene,61 allenes,62 or internal alkynes63 react with o-iodophenol in the presence of carbon monoxide and a palladium catalyst to afford coumaranone, chromone, or coumarin derivatives. In this paper, we report the carbonylation reactions of some ortho-palladated complexes of phenol and some of its derivatives that could be intermediates in some of these catalytic systems. Insertion reactions of isonitriles into Pd-C bonds also constitute a subject of great interest,4,44,45,57,64-69 since they can lead to new types of organopalladium4,44,45,57,64-79 (44) Campora, J.; Graiff, C.; Palma, P.; Carmona, E.; Tiripicchio, A. Inorg. Chim. Acta 1998, 269, 191. (45) Kayaki, Y.; Shimizu, I.; Yamamoto, A. Bull. Chem. Soc. Jpn. 1997, 70, 917. (46) Delis, J. G. P.; Rep, M.; Ru¨lke, R. E.; van Leeuwen, P.; Vrieze, K.; Fraanje, J.; Goubitz, K. Inorg. Chim. Acta 1996, 250, 87. (47) Ankersmit, H. A.; Loken, B. H.; Kooijman, H.; Spek, A. L.; Vrieze, K.; van Koten, G. Inorg. Chim. Acta 1996, 252, 141. (48) Ankersmit, H. A.; Veldman, N.; Spek, A. L.; Eriksen, K.; Goubitz, K.; Vrieze, K.; van Koten, G. Inorg. Chim. Acta 1996, 252, 203. (49) Dekker, G.; Buijs, A.; Elsevier, C. J.; Vrieze, K.; Vanleeuwen, P.; Smeets, W. J. J.; Spek, A. L.; Wang, Y. F.; Stam, C. H. Organometallics 1992, 11, 1937. (50) Toth, I.; Elsevier, C. J. J. Am. Chem. Soc. 1993, 115, 10388. (51) Monteil, F.; Kalck, P. J. Organomet. Chem. 1994, 482, 45. (52) Moser, W. R.; Wang, A. W.; Kjeldahl, N. K. J. Am. Chem. Soc. 1988, 110, 2816. (53) Ozawa, F.; Kawasaki, N.; Okamoto, H.; Yamamoto, T.; Yamamoto, A. Organometallics 1987, 6, 1640. (54) Ozawa, F.; Sugimoto, T.; Yuasa, Y.; Santra, M.; Yamamoto, T.; Yamamoto, A. Organometallics 1984, 3, 683. (55) Anderson, G. K. Organometallics 1983, 2, 665. (56) Grushin, V. V.; Alper, H. Organometallics 1993, 12, 1890. (57) Kim, Y. J.; Song, S. W.; Lee, S. C.; Lee, S. W.; Osakada, K.; Yamamoto, T. J. Chem. Soc., Dalton Trans. 1998, 1775. (58) Garrou, P. E.; Heck, R. F. J. Am. Chem. Soc. 1976, 98, 4115. (59) Grigg, R.; Khalil, H.; Levett, P.; Virica, J.; Sridharan, V. Tetrahedron Lett. 1994, 35, 3197. (60) Moinet, C.; Fiaud, J. C. Synlett 1997, 97. (61) An, Z. W.; Catellani, M.; Chiusoli, G. P. J. Organomet. Chem. 1989, 371, C51. (62) Okuro, K.; Alper, H. J. Org. Chem. 1997, 62, 1566. (63) Kadnikov, D. V.; Larock, R. C. Org. Lett. 2000, 2, 3643. (64) Delis, J. G. P.; Aubel, P. G.; Vrieze, K.; Vanleeuwen, P.; Veldman, N.; Spek, A. L.; Vanneer, F. J. R. Organometallics 1997, 16, 2948. (65) Alias, F. M.; Belderrain, T. R.; Paneque, M.; Poveda, M. L.; Carmona, E.; Valerga, P. Organometallics 1997, 16, 301. (66) Takei, F.; Yanai, K.; Onitsuka, K.; Takahashi, S. Angew. Chem., Int. Ed. Engl. 1996, 35, 1554. (67) Onitsuka, K.; Segawa, M.; Takahashi, S. Organometallics 1998, 17, 4335. (68) Alias, F. M.; Belderrain, T. R.; Paneque, M.; Poveda, M. L.; Carmona, E.; Valerga, P. Organometallics 1998, 17, 5620. (69) Ito, Y.; Miyake, T.; Hatano, S.; Shima, R.; Ohara, T.; Suginome, M. J. Am. Chem. Soc. 1998, 120, 11880. (70) Bertani, R.; Castellani, C. B.; Crociani, B. J. Organomet. Chem. 1984, 269, C15. (71) Onitsuka, K.; Joh, T.; Takahashi, S. J. Organomet. Chem. 1994, 464, 247. (72) Otsuka, S.; Ataka, K. J. Chem. Soc., Dalton Trans. 1976, 327. (73) Crociani, B.; Sala, M.; Polo, A.; Bombieri, G. Organometallics 1986, 5, 1369. (74) Onitsuka, K.; Ogawa, H.; Joh, T.; Takahashi, S.; Yamamoto, Y.; Yamazaki, H. J. Chem. Soc., Dalton Trans. 1991, 1531.

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complexes and because they may be important for organic synthesis.4,69,79-85 Experimental Section Reactions were carried out without precautions to exclude atmospheric moisture, unless otherwise stated. The IR and C, H, and N analyses and melting point determinations were carried out as described elsewhere.10 Unless otherwise stated, NMR spectra were recorded in CDCl3 in a Varian Unity 300 or a Bruker Unity 200. Chemical shifts were referenced to TMS (1H and 13C(1H)) and PO4H3 (31P). Chromatographic separations were carried out by TLC on silica gel (70-230 mesh). Synthesis of 2-Iodophenol Esters.86 C6H4OC(O)CHdCH2-I-2. A suspension of 2-iodophenol (500 mg, 2.23 mmol), acryloyl chloride (205 mg, 2.23 mmol), and K2CO3 (1 g, 7,24 mmol) in acetone (10 mL) was refluxed for 3 h. After addition of water (20 mL) and extraction with Et2O (3 × 5 mL), the organic phase was dried with anhydrous MgSO4 and the solvents evaporated. The resulting crude ester was chromatographed through silica gel with 1.5:1 n-hexane/Et2O. Evaporation of the eluents gave the ester as a colorless clear oil. Yield: 550 mg, 90%. IR (cm-1): ν(CO) 1745. 1H NMR (200 MHz, CDCl3; ppm): 7.85 (d, C6H4, 1 H, 3JHH ) 9.6 Hz), 7.37 (dd, C6H4, 1H, 3JHH ) 9.6 Hz, 3JHH ) 7.3 Hz), 7.12 (d, C6H4, 1H, 3JHH ) 9.6 Hz), 7.00 (dd, C6H4, 1H, 3JHH ) 7.3 Hz, 3J 3 HH ) 9.3 Hz), 6.80 (dd, vinyl H (trans), 1H, JHH ) 18.0 Hz, 2J 3 3 HH ) 1.3 Hz), 6.36 (dd, vinyl H, 1H, JHH ) 18.0 Hz, JHH ) 12.0 Hz), 6.05 (dd, vinyl H (cis), 1H, 3JHH ) 12.0 Hz, 2JHH ) 1.3 Hz). C6H4{OC(O)Me}-I-2. A suspension of 2-iodophenol (240 mg, 1.09 mmol), acetic anhydride (112 mg, 1.09 mmol), and K2CO3 (3 g, 21,72 mmol) in acetone (10 mL) was stirred for 30 min. The solution was filtered through anhydrous MgSO4, and the solvent was evaporated. The resulting crude ester was chromatographed through silica gel with 1.5:1 n-hexane/Et2O. Evaporation of the eluents gave the ester as a colorless clear oil. Yield: 214 mg, 75%. IR (cm-1): ν(CO) 1785. 1H NMR (200 MHz, CDCl3; ppm): 7.82 (d, C6H4, 1H, 3JHH ) 7.8 Hz), 7.37 (dd, C6H4, 1H, 3JHH ) 8.4 Hz, 3JHH ) 7.8 Hz), 7.09 (d, C6H4, 1H, 3JHH ) 10.0 Hz), 7.00 (dd, C6H4, 1H, 3JHH ) 10.0 Hz, 3JHH ) 7.8 Hz), 2.36 (s, 3H, Me). Synthesis of Complexes. trans-[Pd(C6H4OH-2)I(PPh3)2] (1a). “Pd(dba)2” (400 mg, 0.7 mmol), PPh3 (367 mg, 0.14 mmol), and 2-iodophenol (175 mg, 0.8 mmol) were mixed in dry degassed toluene (10 mL) and stirred for 4 h. After evaporation of the solvent and extraction of the residue with CH2Cl2 (10 + 2 × 3 mL), the combined organic extracts were filtered over anhydrous MgSO4. The resulting solution was concentrated (2 mL), and a mixture of the complex and dba was precipitated with n-hexane. Purification by chromatography through silica gel with 1:1.5 Et2O/n-hexane gave a solid, which was recrystallized from CH2Cl2/n-hexane to give 1a as a yellow powder. (75) Delis, J. G. P.; Aubel, P. G.; Vanleeuwen, P.; Vrieze, K.; Veldman, N.; Spek, A. L. J. Chem. Soc., Chem. Commun. 1995, 2233. (76) Dupont, J.; Pfeffer, M. J. Chem. Soc., Dalton Trans. 1990, 3193. (77) Wouters, J. M. A.; Klein, R. A.; Elsevier, C. J.; Zoutberg, M. C.; Stam, C. H. Organometallics 1993, 12, 3864. (78) Yamamoto, Y.; Yamazaki, H. Inorg. Chem. 1974, 13, 438. (79) Campora, J.; Gutierrez, E.; Monge, A.; Palma, P.; Poveda, M. L.; Ruiz, C.; Carmona, E. Organometallics 1994, 13, 1728. (80) Tanase, T.; Fukushima, T.; Nomura, T.; Yamamoto, Y.; Kobayashi, K. Inorg. Chem. 1994, 33, 32. (81) Yamamoto, Y.; Yamazaki, H. Synthesis 1976, 750. (82) O’Sullivan, R. D.; Parkins, A. W. J. Chem. Soc., Chem. Commun. 1984, 1165. (83) Gehrig, K.; Klaus, A. J.; Rys, P. Helv. Chim. Acta 1983, 66, 2603. (84) Veya, P.; Floriani, C.; Chiesivilla, A.; Rizzoli, C. Organometallics 1993, 12, 4899. (85) Albinati, A.; Pregosin, P. S.; Ru¨edi, R. Helv. Chim. Acta 1985, 68, 2046. (86) Beckwith, A. L. J.; Gara, W. B. J. Chem. Soc., Perkin Trans. 1975, 795.

Vicente et al. Yield: 120 mg, 21%. Mp: 161 °C. 1H NMR (300 MHz, CDCl3; ppm): 7.78-7.48 (m, PPh3, 12H), 7.39-7.22 (m, PPh3, 18H), 6.57 (d, C6H4, 1H, 3JHH ) 7.8 Hz), 6.38 (dd, C6H4, 1H, 3JHH ) 7.5 Hz, 3JHH ) 7.8 Hz), 6.03 (dd, C6H4, 1H, 3JHH ) 7.5 Hz, 3 JHH ) 7.2 Hz), 5.78 (d, C6H4, 1H, 3JHH ) 7.2 Hz), 4.99 (s, OH, 1H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 155.05 (t, COH, 3 JCP ) 3.0 Hz), 144.03 (t, Pd-C, 2JCP ) 4.4 Hz), 134.71 (t, o-C of PPh3, 2JCP ) 6.2 Hz), 131.60 (t, P-C, 1JPC ) 23.6 Hz), 129.93 (s, p-C of PPh3), 127.65 (t, m-C of PPh3, 3JCP ) 5.2 Hz), 124.52, 120.03 (2 C), 114.31 (s, C6H4 CH). 31P{1H} NMR (121 MHz, CDCl3; ppm): 22.84. Anal. Calcd for C42H35IOP2Pd: C, 59.28; H, 4.15. Found: C, 58.92; H, 3.98. trans-[Pd{C6H4[OC(O)Me]-2}I(PPh3)2] (1b). “Pd(dba)2” (240 mg, 0.42 mmol), PPh3 (230 mg, 0.88 mmol), and the corresponding 2-iodophenyl ester (131 mg, 0.5 mmol) were mixed in dry degassed toluene (10 mL) and stirred for 4 h. After evaporation of the solvent and extraction of the residue with CH2Cl2 (10 + 2 × 3 mL), the combined organic extracts were filtered over anhydrous MgSO4. The resulting solution was evaporated to approximate 2 mL. Purification by chromatography through silica gel with 1:1.5 Et2O/n-hexane gave a solid, which was recrystallized from CH2Cl2/n-hexane to give 1b as a white powder. Yield: 138 mg, 42%. Mp: 308 °C dec. IR (cm-1): ν(CO) 1760. 1H NMR (200 MHz, CDCl3; ppm): 7.62-7.51 (m, PPh3, 12H), 7.34-7.19 (m, PPh3, 18H), 6.48 (d, C6H4, 1H, 3JHH ) 8.0 Hz), 6.39 (dd, C6H4, 1H, 3JHH ) 8.0 Hz, 3J 3 HH ) 7.6 Hz), 6.23 (d, C6H4, 1H, JHH ) 7.6 Hz), 6.01 (dd, 3 3 C6H4, 1H, JHH ) 8.0 Hz, JHH ) 7.6 Hz), 2.22 (s, Me, 3H). 13C{1H} NMR (50 MHz, CDCl ; ppm): 168.70 (s, CdO), 151.22, 3 150.24 (s, C-O and C-Pd), 137.70 (d, p-C of PPh3, 4JCP ) 4.4 Hz), 134.88 (t, o-C of PPh3, 3JCP ) 6.5 Hz), 132.13 (t, C-P, 1J CP ) 23.5 Hz), 129.80 (s, CH C6H4), 127.65 (t, m-C of PPh3, 2J CP ) 5.0 Hz), 125.15, 122.87, 121.15 (s, CH C6H4), 21.84 (s, Me). 31P{1H} NMR (121 MHz, CDCl3; ppm): 22.59. Anal. Calcd for C44H37IO2P2Pd: C, 59.18; H, 4.16. Found: C, 59.19; H, 4.15. trans-[Pd{C6H4[OC(O)CHdCH2]-2}I(PPh3)2] (1c). The same procedure as for 1b was used, starting from “Pd(dba)2” (229 mg, 0.40 mmol), PPh3 (210 mg, 0.80 mmol), and the corresponding 2-iodophenyl ester (140 mg, 0.49 mmol) to prepare 1c as a yellow powder. Yield: 192 mg, 53%. Mp: 156 °C dec. IR (cm-1): ν(CO) 1726. 1H NMR (300 MHz, CDCl3; ppm): 8.22-8.03 (m, PPh3, 12H), 7.86-7.69 (m, PPh3, 18H), 7.09 (d, vinyl H, 1H, 3JHH ) 15.5 Hz), 7.10 (d, C6H4, 1H, 3JHH ) 9 Hz), 7.00-6.77 (m, C6H4 and vinyl H, 3H), 6.53-6.48 (m, C6H4 and vinyl H, 2H), 13C{1H} NMR (50 MHz, CDCl3; ppm): 164.32 (s, CdO), 151.23, 150.49 (C-O and C-Pd), 137.92 (s, C6H4, CH), 134.90 (t, o-C of PPh3, 2JCP ) 6.4 Hz), 132.11 (t, i-C PPh3, 1JCP ) 23.6 Hz), 131.51 (dCH2), 129.75 (s, p-C of PPh3), 128.91 (CHd), 127.62 (t, m-C of PPh3, 3JCP ) 5.2 Hz), 125.13, 122.93, and 121.04 (s, C6H4, CH). Anal. Calcd for C45H34IO2P2Pd: C, 59.78; H, 3.92. Found: C, 59.92; H, 3.80. [Pd(C6H4OH-2)I(bpy)] (2a). “Pd(dba)2” (121 mg, 0.21 mmol), bpy (66 mg, 0.42 mmol), and o-iodophenol (110 mg, 0.5 mmol) were added to dry degassed toluene (7 mL). After 2.5 h at 0 °C, the solvent was evaporated and the residue was extracted with CH2Cl2 (10 + 2 × 3 mL). The combined extracts were filtered over anhydrous MgSO4 and the resulting solution concentrated (2 mL). Addition of Et2O precipitated a solid, which was recrystallized from CH2Cl2/Et2O and dried in a desiccator in vacuo over P2O5 to give 2a as an orange solid. Yield: 54 mg, 54% (crude); 35 mg, 35% (recrystallized). Mp: 185 °C. IR (cm-1): ν(OH) 3422. 1H NMR (200 MHz, CDCl3; ppm): 9.61 (d, bpy, 1H, 3JHH ) 5.1 Hz), 8.12-8.00 (m, bpy, 3H), 7.52-7.42 (m, bpy and C6H4, 2H), 7.41-7.27 (m, bpy and C6H4, 1H), 7.01-6.96 (m, bpy and C6H4, 1H), 7.66-7.21 (m, bpy and C6H4, 1H), 6.97-6.93 (m, C6H4, 1H), 6.80-6.71 (m, C6H4, 2H), 5.82 (s, OH, 1H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 156.81, 153.94, 152.86 (quaternary C), 150.48, 151.35, 138.87, 138.84 (bpy CH), 135.86, 126.99, 126.75, 125.35, 122.00, 121.61, 120.63, 113.86 (bpy CH and C6H4 CH). Anal.

Ortho-Palladated Phenol Derivatives Calcd for C16H13IN2OPd: C, 39.84; H, 2.72; N, 5.81. Found: C, 39.89; H, 2.59; N, 5.88. [Pd{C6H4[OC(O)Me]-2}I(bpy)] (2b). The same procedure as for 1b was used, starting from “Pd(dba)2” (257 mg, 0.45 mmol), bpy (70 mg, 0.45 mmol), and the corresponding 2-iodophenyl ester (130 mg, 0.5 mmol) in toluene (7 mL) to prepare 2b as a bright yellow powder. Yield: 148 mg, 63%. Mp: 120 °C dec. IR (cm-1): ν(CO) 1757. 1H NMR (200 MHz, CDCl3; ppm): 9.64 (d, bpy, 1H, 3JHH ) 6.0 Hz), 8.10-7.97 (m, bpy, 4H), 7.76 (d, bpy, 1H, 3JHH ) 4.0 Hz), 7.52-7.42 (m, bpy and C6H4, 2H), 7.41-7.27 (m, bpy and C6H4, 1H), 7.01-6.96 (m, bpy and C6H4, 2H), 6.85-6.81 (m, C6H4, 1H), 2.21 (s, Me, 3H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 170.83 (s, CdO), 155.50, 154.09, 153.93 (quaternary C), 153.18, 151.35 (bpy C-H), 138.69, 137.64 (bpy C-H), 135.30 (quaternary C), 126.76, 126.38, 125.06, 124.50, 121.62, 121.57, 121.44 (C6H4 C-H and bpy C-H), 22.03 (Me). Anal. Calcd for C18H15IN2O2Pd: C, 41.21; H, 2.88; N, 5.34. Found: C, 41.18; H, 3.28; N, 5.10. [Pd{C6H4[OC(O)Me-2]}(bpy)PPh3)]OTf (3b). To a suspension of Tl(OTf) (OTf ) OSO2CF3; 23.0 mg, 0.065 mmol) in CH2Cl2 (7 mL) were added complex 1b (55 mg, 0.061 mmol) and, 2-3 min later, bpy (9.53 mg, 0.061 mmol), and the mixture was stirred for 14 h. The resulting suspension was filtered over Celite, and the filtrate was concentrated to dryness to give a bright yellow solid, which was finally recrystallized from CH2Cl2/Et2O to give 3b. Yield: 38 mg, 77%. Mp: 161 °C. IR (cm-1): ν(CO) 1746, ν(SO3) 1268, 1152. 1H NMR (200 MHz, CDCl3; ppm): 8.78-8.70 (m, aromatic H of bpy, 2H), 8.22-8.14 (m, aromatic H of bpy, 2H), 7.63-7.27 (m, aromatic H of PPh3, bpy, 20H), 7.20-6.3 (m, aromatic H of bpy and/or C6H4, 5H), 2.16 (s, Me, 3H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 169.39 (CdO), 155.71, 155.40, 151.70 (quaternary C), 150.82, 150.38 (aromatic CH), 145.22 (d, Pd-C, 2JPC ) 12 Hz), 141.44, 141.33, 135.41, 135.34 (aromatic CH), 134.42 (d, o-C of PPh3, 2JPC ) 11.9 Hz), 131.88 (d, p-C of PPh3, 4JPC ) 2.6 Hz), 129.18, 129.29 (d, m-C of PPh3, 3JPC ) 11.1 Hz), 126.73, 126.48, 126.20, 125.78, 124.79, 124.13, 122.84 (aromatic CH). 31P{1H} NMR (121 MHz, CDCl ; ppm): 33.11. Anal. Calcd for 3 C37H30F3N2O5PPdS: C, 54.93; H, 3.74; N, 3.46; S, 3.96. Found: C, 54.68; H, 3.50; N, 3.24; S, 3.69. [Pd(C6H4{OC(O)C2H3-2})(bpy)PPh3]OTf (3c). The same procedure as for 3b was used, starting from Tl(OTf) (27.5 mg, 0.080 mmol) in CH2Cl2 (7 mL) and 1c (70 mg, 0.078 mmol), to prepare yellow 3c, except that concentrating the filtrate to dryness led to a yellow foam, which was stirred with Et2O for 1 h to remove some PPh3; Et2O was decanted, and the solid was dried in vacuo. Yield: 57 mg, 91.3%. Mp: 158 °C. IR (cm-1): ν(CO) 1734, ν(SO3) 1276, ν(SO3) 1152. 1H NMR (300 MHz, CDCl3; ppm): 9.79-9.73 (m, aromatic H of bpy, 2H), 8.22-8.16 (m, aromatic H of bpy, 2H), 7.75-7.21 (m, aromatic H of PPh3, bpy and C6H4, 21H), 7.05-6.95 (m, aromatic H of bpy and/or C6H4, 2H), 6.78 (dd, C6H4, 1H, 3JHH ) 7.4 Hz, 3JHH ) 7.0 Hz), 6.94 (d, phenyl CH, 1H, 3JHH ) 8.5 Hz), 6.30 (d, terminal vinyl H (trans), 3JHH ) 16.0 Hz, 1H), 6.40 (dd, vinyl H, 1H, 3JHH ) 16.0 Hz, 3JHH ) 10.0 Hz), 6.31 (d, vinyl H (cis), 1H, 3JHH ) 12.0 Hz), 6.05 (d, terminal vinyl H (cis), 1H, 3JHH ) 12.0 Hz). 13C{1H} NMR (50 MHz, CDCl3; ppm): 164.59 (CdO), 155.71, 155.38, 151.68 (quaternary C), 150.90, 150.34 (CH, bpy), 145.40 (d, Pd-C, 2JPC ) 11.9 Hz), 143.29, 141.46, 141.32, 135.45, 135.38 (CH, bpy), 134.45 (d, o-C of PPh3, 2JPC ) 12 Hz), 132.60 (dCH2), 132.15 (CH), 132.00 (dCH), 131.87 (d, p-C of PPh3, 4JPC ) 3 Hz), 129.17 (P-C; one part of the doublet, the other part might be below the next PPh3 m-C signal), 129.80 (d, m-C of PPh3, 3JPC ) 11.0 Hz), 128.61, 128.37, 128.11, 126.71, 126.43, 126.23, 125.89, 124.78, 124.06, 122.80 (aromatic CH). 31P{1H} NMR (121 MHz, CDCl3; ppm): 33.82. Anal. Calcd for C38H30F3N2O5PPdS: C, 55.59; H, 3.68; N, 3.41; S, 3.91. Found: C, 55.18; H, 3.70 N, 3.73; S, 4.20. trans-[Pd{C(O)C6H4OH-2}I{PPh3)2] (4a). CO was bubbled through a solution of 1a (80 mg, 0.09 mmol) CH2Cl2 (10 mL)

Organometallics, Vol. 20, No. 13, 2001 2707 for 45 min. The solution was stirred for a further 1 h under an atmosphere of CO and concentrated (2 mL), and addition of n-hexane precipitated a solid, which was filtered and washed with n-hexane (10 mL) to give 4a as a yellow solid. Yield: 69 mg, 84%. Mp: 194 °C dec. IR (cm-1): ν(CO) 1570. 1H NMR (200 MHz, CDCl3; ppm): 9.72 (s, OH, 1H), 8.64 (d, C6H4 H ortho to CdO, 3JHH ) 7.2 Hz, 1H), 7.61-7.58 (m, PPh3, 12H), 7.29-7.20 (m, PPh3, 18H), 6.97 (dd, C6H4, 1H, 3JHH ) 7.4 Hz, 3 JHH ) 7.2 Hz), 6.01 (dd, C6H4, 1H, 3JHH ) 7.4 Hz, 3JHH ) 7.0 Hz), 6.94 (d, C6H4, 1H, 3JHH ) 8.5 Hz). 13C{1H} NMR (50 MHz, CDCl3; ppm): 245.57 (s, CO), 156.75 (s, COH), 135.19 (t, C6H4 CH), 4JCP ) 2.4 Hz), 134.88 (t, o-C of PPh3, 2JCP ) 6.2 Hz), 133.55 (s, C6H4 CH), 131.09 (t, C-P, 1JCP ) 22.9 Hz), 130.30 (s, p-C of PPh3), 128.00 (t, m-C of PPh3, 3JCP ) 2.1 Hz), 125.27 (t, C(O)-Carom, 3JPC ) 12 Hz), 118.39, 116.29 (s, C6H4 CH). 31P{1H} NMR (121 MHz, CDCl ; ppm): 18.88. Anal. Calcd for 3 C43H35IO2P2Pd: C, 58.76; H, 4.01. Found: C, 58.09; H, 4.00. [Pd{C(O)C6H4OH-2}I(bpy)] (5a). CO was bubbled through a solution of 2a (80 mg, 0.17 mmol) in CH2Cl2 (10 mL) for 30 min. The solution was stirred for a further 1 h under an atmosphere of CO and concentrated (2 mL), and addition of Et2O precipitated a solid, which was filtered and washed with Et2O (10 mL) to give 5a as a red-orange solid. Yield: 78 mg, 92%. Mp: 268 °C dec. IR (cm-1): ν(CO) 1596. 1H NMR (200 MHz, DMSO-d6; ppm): 10.25 (s, OH, 1H), 8.64-8.58 (m, bpy and C6H4, 3H), 8.30-8.25 (m, bpy and C6H4, 3H), 7.80-7.61 (m, bpy and C6H4, 3H), 7.30-7.27 (m, C6H4 or bpy H, 1H), 6.81-6.73 (m, C6H4 or bpy H, 2H). 13C{1H} NMR (50 MHz, CDCl3; ppm): not sufficiently soluble. Anal. Calcd for C17H13IN2O2Pd: C, 39.99; H, 2.57; N 5.49. Found: C, 39.86; H, 2.42; N, 5.49. [Pd{C(O)C6H4OH-2}(bpy)PPh3)]OTf (6a). To a suspension of Tl(OTf) (25.3 mg, 0.072 mmol) in CH2Cl2 (7 mL) was added complex 4a (63 mg, 0.072 mmol). After 5 min, bpy (11.2 mg, 0.072 mmol) was added and the resulting mixture stirred for 6 h. The suspension was filtered over Celite to give a yellow solution, which was concentrated (2 mL). Addition of n-hexane gave a solid, which was recrystallized from CH2Cl2/n-hexane to give 6a as a bright yellow powder. Yield: 49 mg, 86%. Mp: 121 °C dec. IR (cm-1): ν(CO) 1600, ν(SO3) 1266, 1148. 1H NMR (300 MHz, CDCl3; ppm): 10.08 (s, OH, 1H), 8.81 (d, bpy H, 2H, 3JHH ) 8.4 Hz), 8.61 (d, C6H4 ortho to CdO, 1H, 3JHH ) 8.1 Hz), 8.22 (dd, bpy H, 2H, 3JHH ) 8.1 Hz, 3JHH ) 8.1 Hz), 7.68-7.62 (m, aromatic H, 7H), 7.57-7.49 (m, aromatic H, 3H), 7.46-7.37 (m, aromatic H, 7H), 7.32-7.26 (m, aromatic H, 3H), 6.87 (dd, C6H4, 1H, 3JHH ) 6.0 Hz, 3JHH ) 6.3 Hz), 6.35 (d, C6H4, 1H, 3JHH ) 8.4 Hz). 13C{1H} NMR (50 MHz, CDCl3; ppm): 235.98 (CO), 157.54 (quaternary C, COH), 155.01 (quaternary C), 150.17, 141.69 (CH, bpy), 135.59, 135.36 (CH, bpy), 134.25 (d, o-C of PPh3, 2JPC ) 12.5 Hz), 132.01 (d, p-C of PPh3, 4JPC ) 2.2 Hz), 129.29(d, m-C of PPh3, 3JPC ) 11.1 Hz), 128.61, 128.37, 126.88, 125.05 (aromatic CH), 122.05 (quaternary C), 119.81, 117.14 (C6H4 CH). The signal of P-C is probably obscured by the signals of m-C of PPh3. 31P{1H} NMR (121 MHz, CDCl3; ppm): 29.44. Anal. Calcd for C36H28F3N2O5PPdS: C, 54.39; H, 3.55; N, 3.52; S, 4.03. Found: C, 54.78; H, 3.48; N, 3.24; S, 4.25. trans-[Pd{C(dNXy)C6H4OH-2}I(CNXy)2] (7a). Method A. “Pd(dba)2” (240 mg, 0.42 mmol) and XyNC (115 mg, 0.85 mmol) were added to dry degassed toluene (10 mL) at 0 °C and stirred under N2. After 5 min, C6H4OH-I-2 (300 mg, 1.36 mmol) was added and the reaction mixture stirred for a further 4 h and for 20 h more at room temperature. The resulting suspension was evaporated to dryness, the residue was extracted with CH2Cl2, and the extract was filtered over anhydrous MgSO4. The orange filtrate was concentrated to 2-3 mL, and Et2O was added. After a few minutes of stirring complex 7a precipitated as a pale yellow solid. Diffractionquality crystals were grown by slow diffusion of Et2O into a CH2Cl2 solution of 7a. Yield: 130 mg, 64% (calculated assuming eqs 1-3; see below).

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Method B. To a solution of 2a (60 mg, 0.12 mmol) in CH2Cl2 (10 mL) at 0 °C was added XyNC (44 mg, 0.37 mmol), and the mixture was stirred for 3 h. The solution was concentrated (2-3 mL), and n-hexane was added to give a suspension. The solid was filtered off and washed with n-hexane (10 mL) to give 7a as a pale yellow powder. Yield: 50 mg, 56%. Mp: 195 °C dec. IR (cm-1): ν(CtN) 2176, ν(CdN) 1556. 1H NMR (200 MHz, CDCl3; ppm): 13.66 (s, OH, 1H), 8.61 (d, H of C6H4 ortho to CdN, 1H, 3JHH ) 7.0 Hz), 7.38-7.19 (m, aromatic H of C6H4 and isonitrile, 3H), 7.08-6.96 (m, aromatic H of C6H4 and isonitrile, 9H), 2.20 (s, Me, 12H), 2.16 (s, Me, 6H). 13C{1H} NMR (75 MHz, CDCl3; ppm): 188.19 (CdN), 158.10 (COH), 147.79 (quaternary C, -NC), 136.70 (CH), 136.04 (quaternary C, C-Me), 131.75 (CH), 130.20 (CH), 128.25 (CH), 128.08 (CH), 124.60 (CH), 118.38 (CH), 116.21 (aromatic CH), 18.85, 18.57 (Me). Anal. Calcd for C33H32IN3OPd: C, 55.05; H, 4.48; N, 5.84. Found: C, 55.20; H, 4.42; N, 5.78. trans-[Pd{C(dNtBu)C6H4OH-2}I(CNtBu)2] (7a*). Method A for 7a was used, starting from “Pd(dba)2” (240 mg, 0.42 mmol), tBuNC (70 mg, 0.84 mmol), and C6H4(OH)-I-2 (111 mg, 0.504 mmol). Reaction time: 1 h at 0 °C and 2 h at room temperature. The CH2Cl2 solution was concentrated, and a large excess of n-hexane was added. The solvent was decanted and the solid dried in vacuo to give 7a* as a bright yellow solid. Yield: 130 mg, 81% (calculated assuming eqs 1-3; see below). Mp: 141 °C dec. IR (cm-1): ν(CtN) 2198, ν(CdN) 1572. 1H NMR (300 MHz, CDCl3; ppm): 15.89 (vb s, OH, 1H), 8.46 (d, H of C6H4 ortho to CdN, 1H, 3JHH ) 9.0 Hz), 7.20 (dd, C6H4, 1H, 3JHH ) 7.5 Hz, 3JHH ) 9.0 Hz), 6.83 (m, C6H4, 1H), 6.79 (d, H of C6H4 ortho to OH, 1H, 3JHH ) 7.5 Hz), 1.63 (s, tBu, 9H), 1.37 (s, 2xtBu, 18H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 182.03 (CdN), 159.56 (COH), 136.57 (CH, C6H4), 130.56 (CH, C6H4), 128.99, 127.53 (quaternary C and terminal t BuNC), 117.01 (CH, C6H4), 116.13 (CH, C6H4), 65.80, 57.02 (quaternary C of tBu), 31.06, 29.65 (Me). Anal. Calcd for C21H32IN3OPd: C, 43.80; H, 5.60; N, 7.30. Found: C, 43.76; H, 5.60 N, 7.35. trans-[Pd{C(dNXy)C6H4OC(O)Me-2}I(CNXy)2] (7b). Method A for 7a was used, starting from “Pd(dba)2” (240 mg, 0.42 mmol), XyNC (165 mg, 1.26 mmol), and 2-MeCO2C6H4I (132 mg, 0.50 mmol). Reaction time: 4 h at 0 °C and 3 days at room temperature. The CH2Cl2 solution was concentrated and n-hexane added, causing the precipitation of a green powder. A concentrated CH2Cl2 solution was subjected to preparative thin-layer chromatography using 1:1 Et2O/n-hexane through silica gel. The pink fraction was collected and extracted with CH2Cl2. This solution was concentrated (2 mL), n-hexane was added very slowly to form two layers, and the flask was stored at -15 °C. Over 3 days, complex 7b precipitated as a yellow solid that did not need further purification. Diffraction-quality crystals were grown by slow diffusion of n-hexane into a CH2Cl2 solution of 7b. Yield: 182 mg, 57%. Mp: 213 °C. IR (cm-1): ν(CtN) 2182, ν(CO) 1766, ν(CdN) 1586. 1H NMR (300 MHz, CDCl3; ppm): 8.61 (d, H of C6H4 ortho to CdN, 1H, 3JHH ) 7.5 Hz), 7.42-6.94 (m, aromatic H of C6H4 and isonitrile, 9H), 7.08-6.96 (m, aromatic H of C6H4 and isonitrile, 3H), 2.33 (s, Me, 3H), 2.19 (s, Me, 12H), 2.13 (s, Me, 6H).13C{1H} NMR (75 MHz, CDCl3; ppm): 172.30 (CdN), 169.71 (CdO), 150.16, 147.42, 134.04, 137.20 (quaternary C), 135.80 (CH), 132.15, 131.95 (quaternary C), 130.61 (CH), 130.15 (quaternary C), 129.69, 129.18, 128.67, 127.10, 126.19 (CH), 125.34 (quaternary C), 124.18, 122.79, 122.44 (CH), 22.00 (MeC(O)), 18.78, 18,55, 18,43 (Me). Anal. Calcd for C35H34IN3O2Pd: C, 55.17; H, 4.50; N, 5.51. Found: C, 55.40; H, 4.38; N, 5.99. trans-[Pd{C(dNtBu)C6H4OC(O)Me-2}I(CNtBu)2] (7b*). To a solution of 2b (50 mg, 0.10 mmol) in CH2Cl2 (10 mL) at 0 °C was added tBuNC (24 mg, 0.30 mmol) (the initially yellow solution immediately became pale yellow), and the mixture was stirred for a further 3 h. After 3 h the clear reaction mixture was evaporated to approximately 2-3 mL; addition

Vicente et al. of n-hexane precipitated a solid, which was filtered off, washed with a further 10 mL of n-hexane, and air-dried to give 7b* as a pale yellow powder. Yield: 37 mg, 60%. Mp: 144 °C dec. IR (cm-1): ν(CtN) 2190, ν(CO) 1758, ν(CdN) 1636. 1H NMR (300 MHz, CDCl3; ppm): 7.59-7.56 (m, H of C6H4 ortho to CdN, 1H), 7.27-7.22 (m, C6H4, 2H), 6.98 (m, H of C6H4 ortho to OH, 1H), 2.25 (s, Me, 3H), 1.55 (s, tBu, 9H), 1.47 (s, 2 × t Bu, 18H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 173.17 (CdN), 168.97 (CdO), 144.48 (COH), 136.01 (quaternary C), 131.45, 128.18, 125.54, 123.51 (CH), 57.97, 56.60 (quaternary C of tBu), 30.00, 29.78 (tBu), 21.34 (Me). Anal. Calcd for C23H34IN3O2Pd: C, 44.71; H, 5.55; N, 6.80. Found: C, 44.54; H, 5.49; N, 6.77. [Pd{C(dNXy)C6H4OH-2}I(bpy)] (8a). XyNC (25 mg, 0.19 mmol) was added to a solution of 2a (100 mg, 0.21 mmol) in CH2Cl2 (10 mL). The mixture was stirred for 8 h, the resulting suspension filtered, and the solid washed with a mixture of CH2Cl2 (10 mL) and Et2O (5 mL) to give 8a as a yellow solid. Yield: 70 mg, 54%. Mp: 248 °C dec. IR (cm-1): ν(CdN) 1536. NMR: not sufficiently soluble. Anal. Calcd for C25H22IN3OPd: C, 48.92; H, 3.61; N 6.85. Found: C, 47.21; H, 3.74; N, 6.87. The insolubility of 8a prevented recrystallization. [Pd{C(dNtBu)C6H4OH-2}I(bpy)] (8a*). tBuNC (9 mg, 0.11 mmol) was added to a solution of 2a (63 mg, 0.11 mmol) in CH2Cl2 (10 mL) at 0 °C and the mixture stirred for 3 h. The solvent was evaporated, the residue dissolved in CH2Cl2 (2 mL), and this solution chromatographed through silica gel with 1.5:1 CH2Cl2/Et2O as eluant. The yellow band was collected and extracted with acetone. Evaporation of the solvent and recrystallization of the residue from CH2Cl2/Et2O gave 8a* as a yellow-orange powder. Yield: 41 mg, 66%. Mp: 256 °C dec. IR (cm-1): ν(CdN) 1598. 1H NMR (200 MHz, acetone-d6; ppm): 13.90 (s, OH, 1 H), 9.50 (d, bpy, 1H, 3JHH ) 5.3 Hz), 9.06 (dd, bpy, 1H, 3JHH ) 8.3 Hz, 3JHH ) 8.0 Hz), 8.61-8.09 (m, bpy, 5H), 7.83-7.66 (m, bpy, 2H), 7.22-7.00 (m, bpy and C6H4, 2H), 6.66-6.58 (m, C6H4, 2H), 1.68 (s, 9H, tBu). 13C{1H} NMR: not sufficiently soluble. Anal. Calcd for C21H22IN3OPd: C, 44.59; H, 3.92; N 7.43. Found: C, 45.21; H, 4.01; N, 7.62. [Pd{C(dNXy)C6H4[OC(O)Me]-2}I(bpy)] (8b). XyNC (22 mg, 0.17 mmol) was added to a solution of 2b (87 mg, 0.17 mmol) in CH2Cl2 (10 mL) at 0 °C. The resulting solution was slowly warmed to room temperature and stirred for a further 14 h. The solution was concentrated (2 mL), and addition of n-hexane caused the precipitation of a yellow-orange powder, which was purified by chromatography through silica gel using 1.5:1 CH2Cl2/Et2O. Diffraction-quality crystals were grown by slow diffusion of Et2O into a CH2Cl2 solution of 8b. Yield: 77 mg, 69%. Mp: 215 °C dec. IR (cm-1): ν(CO) 1768, ν(CdN) 1614. 1H NMR (300 MHz, CDCl ; ppm): 9.42 (d, bpy, 3J 3 HH ) 7.0 Hz, 1H), 9.27 (dd, bpy, 1H, 3JHH ) 7.8 Hz, 3JHH ) 8.1 Hz), 8.55 (d, aromatic H, 3JHH ) 5.7 Hz, 1H), 8.01-7.90 (m, aromatic H, 4H), 7.45-6.62 (m, aromatic H, 8H), 2.14 (b s, Me, 6H), 2.10 (s, Me, 3H). 13C{1H} NMR: not sufficiently soluble. Anal. Calcd for C27H24IN3O2Pd: C, 49.45; H, 3.69; N 6.41. Found: C, 49.96; H, 3.55; N, 6.33. [Pd{C(dNXy)C6H4OH-2}(CNXy)(bpy)]OTf (9a). Complex 7a (46 mg, 0.064 mmol) was added to a suspension of Tl(OTf) (25 mg, 0.071 mmol) in CH2Cl2 (7 mL). After 5 min, bpy (11 mg, 0.011 mmol) was added and the mixture stirred for a further 14 h. The resulting suspension was filtered, the filtrate was concentrated (1 mL), and an excess of Et2O was added to precipitate the pale yellow, flocculent complex 9a. Yield: 43 mg, 74%. Mp: 185 °C dec. IR (cm-1): ν(CtN) 2158, ν(CdN) 1564, ν(SO3) 1268, 1090. 1H NMR (200 MHz, CDCl3; ppm): 13.36 (s, OH, 1H), 8.83-8.80 (m, aromatic H, 2H), 8.63 (dd, aromatic H, 1H, 3JHH ) 7.8 Hz, 3JHH ) 7.8 Hz), 8.36-8.26 (m, aromatic H, 3H), 8.09 (d, aromatic H, 1H, 3JHH ) 4.8 Hz), 7.70 (dd, aromatic H, 1H, 3JHH ) 6.7 Hz, 3JHH ) 6.1 Hz), 7.506.91 (m, aromatic H, 10H), 2.19 (s, Me, 6H), 1.99 (s, Me, 3H), 1.85 (s, Me, 3H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 188.75 (CdN), 159.35, 156.60, 153.32 (quaternary C), 150.65 (CH),

Ortho-Palladated Phenol Derivatives 150.11, 147.67 (quaternary C), 142.51, 142.22 (CH), 135.72 (quaternary C), 135.39, 133.09, 131.15, 128.56, 128.27, 128.24, 127.32, 125.19 (CH), 125.14, 122.74 (quaternary C), 119.21, 117.00(CH),18.56(Me),15.23(Me).Anal.CalcdforC35H31F3N4O4SPd: C, 54.80; H, 4.07; N, 7.30; S, 4.18. Found: C, 55.03; H, 4.32; N, 7.35; S, 3.68. trans-[Pd{C(O)C6H4OH-2}I(CNXy)2] (10a). CO was bubbled through a solution of 2a (60 mg, 0.12 mmol) in CH2Cl2 (10 mL) for 40 min. The resulting deep orange solution was stirred for a further 30 min under an atmosphere of CO. The flask was then cooled in an ice bath, and XyNC (33 mg, 0.25 mmol) was added, causing a change of color of the reaction mixture from orange to yellow. After 3 h of further stirring at 0 °C, the solution was concentrated (2 mL) and Et2O was added. The resulting suspension was filtered and the solid washed with Et2O (10 mL) to give 10a as a red-orange powder. Yield: 62 mg, 84%. Mp: 129 °C dec. IR (cm-1): ν(CtN) 2182, ν(CO) 1626. 1H NMR (200 MHz, CDCl3; ppm): 10.79 (s, OH, 1H), 8.75 (d, H of C6H4 ortho to CdO, 3JHH ) 7.1 Hz, 1H), 7.44 (dd, aromatic H of C6H4 or isonitrile, 1H, 3JHH ) 7.1 Hz, 3JHH ) 7.2 Hz), 7.26-7.04 (m, C6H4 and isonitrile H, 7H), 6.91 (d, C6H4, 1H, 3JHH ) 8.2 Hz), 2.29 (s, Me, 12H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 230.03 (CdO), 156.25 (COH), 137.78, 136.20, 135.00, 130.28 (CH), 128.43 (quaternary C), 119.80, 116.67 (CH C6H4), 18.51 (Me). Anal. Calcd for C25H24IN2OPd: C, 48.65; H, 3.76; N 4.54. Found: C, 48.10; H, 3.63; N, 4.62. trans-[Pd{C(O)C6H4OH-2}I(CNtBu)2] (10a*). Complex 10a* was similarly prepared from 2a (70 mg, 0.15 mmol) and tBuNC (36 mg, 0.44 mmol). Orange-brown 10a* was precipitated with n-hexane. Yield: 59 mg, 78%. Mp: 128 °C dec. IR (cm-1): ν(CtN) 2206, ν(CO) 1618. 1H NMR (200 MHz, CDCl3; ppm): 10.78 (s, OH, 1H), 8.54 (d, H of C6H4 ortho to CdO, 3J 3 3 HH ) 8.0 Hz, 1H), 7.43 (dd, C6H4, 1H, JHH ) 8.0 Hz, JHH ) 7.1 Hz), 7.23-7.03 (m, C6H4, 1H), 6.89 (d, C6H4, 1H, 3JHH ) 8.2 Hz), 1.40 (s, tBu, 18H). 13C (1H) NMR (50 MHz, CDCl3; ppm): 230.93 (CdO), 156.20 (COH), 137.61 (CH C6H4), 135.13 (quaternary C), 134.58 (CH C6H4), 127.80, 125.85, 123.92 (quaternary C), 119.44, 116.49 (CH C6H4), 58.36 (quaternary C of tBu), 29.72 (tBu). Anal. Calcd for C17H23INO2Pd: C, 40.46; H, 4.59; N 5.55. Found: C, 40.27; H, 4.07; N, 5.33. [Pd{C(O)C6H4OH-2}(CNXy)3]OTf (11a). CO was bubbled through a solution of 2a (64 mg, 0.13 mmol) in CH2Cl2 (10 mL) for 30 min, and the resulting deep orange solution was stirred for a further 1/2 h under an atmosphere of CO. The flask was cooled to 0 °C, XyNC (139 mg, 1.06 mmol) was added (causing decolorization), and the mixture was stirred for 15 min. Tl(OTf) (50 mg, 0.14 mmol) was added, and the resulting suspension stirred for 4 h more at 0 °C and filtered over Celite. The filtrate was concentrated (2 mL), and addition of Et2O precipitated a solid, which was filtered and washed with Et2O (10 mL) to give 11a as a white powder. Yield: 58 mg, 57%. Mp: 97 °C dec. IR (cm-1): ν(CtN) 2186, ν(CO) 1622. 1H NMR (200 MHz, CDCl3; ppm): 10.31 (s, OH, 1H), 8.37 (d, H of C6H4 ortho to CdO, 3JHH ) 6.6 Hz, 1H), 7.43 (dd, aromatic H of C6H4 or isonitrile, 1H, 3JHH ) 8.4 Hz, 3JHH ) 7.6 Hz), 7.266.96 (m, C6H4 and isonitrile H, 11H), 2.25 (b s, Me, 18H). 13C (1H) NMR (50 MHz, CDCl3; ppm): 11a decomposed in CDCl3 solution after 1 h. Anal. Calcd for C35H32F3N3O5PdS: C, 54.59; H, 4.19; N, 5.46; S, 4.16. Found: C, 54.26; H, 4.26; N, 5.68; S, 4.01. [Pd{C(O)C6H4OH-2}(CNtBu)3]OTf (11a*). Complex 11a* was similarly prepared from 2a (64 mg, 0.13 mmol), tBuNC (90 mg, 1.06 mmol), and Tl(OTf) (50 mg, 0.14 mmol). White 11a* was precipitated by addition of n-hexane. Yield: 62 mg, 71%. Mp: 88 °C dec. IR (cm-1): ν(CtN) 2224, ν(CO) 1586. 1H NMR (200 MHz, CDCl3; ppm): 10.42 (s, OH, 1H), 8.24 (d, H of C6H4 ortho to CdO, 3JHH ) 7.5 Hz, 1H), 7.43 (dd, C6H4, 1H, 3J 3 3 HH ) 8.4 Hz, JHH ) 7.6 Hz), 7.20 (dd, C6H4, 1H, JHH ) 8.2 Hz, 3JHH ) 7.6 Hz), 6.93 (d, C6H4, 3JHH ) 8.2 Hz, 1H), 1.61 (s, tBu, 9H), 1.43 (s, tBu, 18H). 13C (1H) NMR (50 MHz, CDCl ; 3

Organometallics, Vol. 20, No. 13, 2001 2709 ppm): 11a* decomposed in CDCl3 solution after 1 h. Anal. Calcd for C23H32F3N3O5PdS: C, 44.13; H, 5.15; N, 6.71; S,5.12. Found: C, 43.96; H, 5.31; N, 6.93; S, 5.29. [Pd{K2(C,O)-µ2(O)-C(dNXy)C6H4O-2}(CNXy)]4 (12). To a yellow suspension of 7a (25 mg, 0.035 mmol) in acetone (10 mL) was added Pd(OAc)2 (4 mg, 0.017 mmol) at room temperature. After 2.5 h, the mixture was evaporated to dryness, the residue was dissolved in CH2Cl2 (2 mL), and Et2O was added to precipitate a solid that was filtered, washed with n-hexane (5 mL), and finally air-dried to give 12 as a yellow solid. Diffraction-quality crystals were grown by slow diffusion of n-hexane into a very dilute solution of 12 in CH2Cl2. Yield: 13 mg, 81%. Mp: 154 °C dec. IR (cm-1): ν(CtN) 2184, ν(CdN) 1642. 1H NMR (300 MHz, CDCl3; ppm): 7.83 (d, H of C6H4 ortho to CdN, 4H, 3JHH ) 7.8 Hz), 7.29-7.13 (m, aromatic H of isonitrile, 12 H), 6.80-6.71 (m, aromatic H, 12 H), 6.47 (dd, C6H4, 4H, 3JHH ) 7.5 Hz, 3JHH ) 7.2 Hz), 6.32 (d, C6H4 1-H, 4H, 3JHH ) 8.4 Hz), 6.22 (dd, C6H4, 4H, 3JHH ) 7.2 Hz, 3 JHH ) 7.5 Hz), 2.22 (s, Me, 24H), 2.20 (s, Me, 24H). 13C{1H} NMR (50 MHz, CDCl3; ppm): 169.75 (CdN), 151.87 (COH), 134.46 (CH), 132.38 (PdCNR′), 132.05 (CH), 129.05 (CH), 128.19 (quaternary C, Pd-C(dNXy)C6H4-), 127.61, 127.42 (CH), 126.89 (quaternary C, C-Me), 126.76, 123.12, 116.90, 115.36 (CH), 19.30, 18.52 (Me). Anal. Calcd for C96H88N8O4Pd4: C, 62.55; H, 4.81; N, 6.08. Found: C, 63.23; H, 4.86; N, 5.76. The complex [PdI2(CNXy)2] is obtained on workup of the mother liquors from 12. Yield: 9 mg, 83%. Mp: 129 °C dec. IR (cm-1): ν(CtN) 2194. 1H NMR (300 MHz, CDCl3; ppm): 7.16 (m, H ortho to CMe, 4 H), 7.13 (m, H meta to CMe, 2 H), 2.57 (s, Me, 12H). Anal. Calcd for C18H18I2N2Pd: C, 34.73; H, 2.91; N, 4.50. Found: C, 35.15; H, 2.86; N, 4.66. X-ray Structure Determinations. A summary of X-ray data is presented in Table 1. Data Collection. Data were recorded at low temperature using Mo KR radiation. Appropriate absorption corrections (multiscan for area detector data, ψ-scan for others) were applied. Structure Refinement. Structures were refined anisotropically on F2 using the program SHELXL-97 (G. M. Sheldrick, University of Go¨ttingen, Go¨ttingen, Germany). Hydrogen atoms were refined as follows: OH, restrained in 7a, rigid group in 5a, 12; methyls, riding in solvent of 9a, otherwise rigid; all others riding. Special Features. The isonitrile C31-C38 in compound 7b is disordered over two sites with occupation factors 0.64/ 0.36. Compound 9a crystallizes with one ether molecule, which is well-ordered. The structure of 12 contained badly resolved residual electron density disordered about the 4-fold axis. This was arbitrarily refined as two carbon sites. Quoted values for M and related parameters of 12 do not include solvent.

Results and Discussion Synthesis of Complexes 1-3. 2-Iodophenol and its derivatives 2-ROC6H4I, where R ) C(O)Me, C(O)CHdCH2, react with [Pd2(dba)3]‚dba (“Pd(dba)2”) in the presence of neutral ligands to give the products of the oxidative addition reactions. Thus, the reaction in the presence of 2 equiv of PPh3 results in the formation of trans-[Pd(C6H4OR-2)I(PPh3)2] (R ) H (1a), C(O)Me (1b), C(O)CHdCH2 (1c)) (Scheme 1). Similarly, the use of 2,2′-bipyridine (bpy) led to complexes [Pd(C6H4OR-2)I(bpy)] (R ) H (2a), C(O)Me (2b)), although the reaction of C6H4[OC(O)CHdCH2]-I-2 with “Pd(dba)2” in the presence of bpy failed to give the corresponding complex. Such a procedure has been shown to be useful for the synthesis of organopalladium complexes containing

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Vicente et al.

Table 1. Details of Data Collection and Structure Refinement for the Complexes 5a, 7a, 7b, 8b, 9a, and 12 chem formula cryst habit cryst size/mm λ/Å cryst syst space group a/Å b/Å c/Å R/deg β/deg γ/deg V/Å3 Z Dc/g cm-3 Mr F(000) diffractometer T/°C 2θmax/deg µ(Μo KR)/mm-1 transmissn no. of rflns measd no. of unique rflns Rint R(F > 4σ(F))a Rw(F2, all rflns)b no. of params no. of restraints Sc max ∆F/e Å-3

5a

7a

7

8b

9a‚C4H10O

12

C17H13IN2O2Pd yellow column 0.25 × 0.05 × 0.04 0.710 73 triclinic P1 h 8.8284(3) 9.2319(4) 10.7891(3) 74.104(3) 89.026(3) 76.708(4) 822.04 2 2.063 510.59 488 Siemens SMART -100 52 3.0 0.45-0.99 4775

C33H32IN3OPd colorless column 0.7 × 0.2 × 0.15 0.710 73 triclinic P1 h 9.0188(14) 16.689(2) 21.851(3) 112.344(8) 90.559(10) 98.875(10) 2997.1 4 1.595 719.92 1432 Siemens P4 -100 50 1.68 0.79-0.93 13 576

C35H34IN3O2Pd pale yellow lath 0.7 × 0.2 × 0.06 0.710 73 orthorhombic Pbca 14.8140(18) 20.550(2) 21.620(3) 90 90 90 6581.4 8 1.538 761.95 3040 Siemens P4 -100 50 1.54 0.68-0.89 5815

C27H24IN3O2Pd orange prism 0.26 × 0.09 × 0.07 0.710 73 monoclinic P21/n 10.0568(8) 13.3006(12) 18.6197(16) 90 103.876(3) 90 2417.9 4 1.802 655.79 1288 Bruker SMART -130 60 2.07 0.81-0.96 19 897

C39H41F3N4O5PdS colorless tablet 0.45 × 0.4 × 0.12 0.710 73 triclinic P1 h 8.5339(3) 14.9785(4) 17.2207(4) 112.118(3) 95.685(3) 101.822(3) 1957.95 2 1.427 841.22 864 Siemens SMART -100 56.6 0.59 0.89-0.99 13 301

C96H88N8O4Pd4 yellow block 0.15 × 0.10 × 0.10 0.710 73 tetragonal P4/n 19.5269(14) 19.5269(14) 12.2839(12) 90 90 90 4683.8 2 1.307 1843.34 1872 Bruker SMART -130 52.7 0.81 0.77-0.98 29 815

3181

10 263

5783

7041

9338

4796

0.043 0.058 0.139 209 49 1.00 0.92

0.016 0.025 0.053 723 171 0.95 0.41

0.17 0.039 0.068 421 586 0.79 0.39

0.041 0.038 0.084 310 69 0.98 1.3

0.017 0.034 0.084 483 3 1.05 0.60

0.101 0.038 0.111 261 233 0.91 1.54

a R(F) ) ∑||F | - |F ||/∑|F |. b R (F2) ) [∑{w(F 2 - F 2)2}/∑{w(F 2)2}]0.5; w-1 ) σ2(F 2) + (aP)2 + bP, where P ) [F 2 + 2F 2]/3 and a and o c o w o c o o o c b are constants adjusted by the program. c S ) [∑{w(Fo2 - Fc2)2}/(n - p)]0.5, where n is the number of data and p the number of parameters.

Scheme 1

nitrogen87,88 or phosphorus89 donor ligands, and we have recently applied it to the synthesis of ortho-palladated anilines.2,5 The trans geometry of 1a-c was confirmed by the appearance of one singlet in their 31P NMR spectra. Complexes 1b,c react with bpy in the presence of Tl(OTf) (OTf ) OSO2CF3) to give the cationic species [Pd(C6H4OR-2)(bpy)(PPh3)]OTf (R ) C(O)Me (3b), C(O)CHdCH2 (3c)) (Scheme 1). As far as we are aware, these (87) Vanasselt, R.; Vrieze, K.; Elsevier, C. J. J. Organomet. Chem. 1994, 480, 27. (88) Markies, B. A.; Canty, A. J.; Degraaf, W.; Boersma, J.; Janssen, M. D.; Hogerheide, M. P.; Smeets, W. J. J.; Spek, A. L.; van Koten, G. J. Organomet. Chem. 1994, 482, 191.

Scheme 2

are the first ortho-palladated complexes of phenol and its derivatives. CO Insertions. We have tested the reactions of complexes 1 and 2 with carbon monoxide, observing that the ortho-palladated phenol derivatives 1a and 2a insert CO to give the aroylpalladium complexes trans-[Pd{C(O)C6H4OH-2}I(PPh3)2] (4a) and [Pd{C(O)C6H4OH2}I(bpy)] (5a) (Scheme 2). With the palladated acetic acid esters 1b and 2b a partial carbonylation takes place; in the case of 1b the isolated solid is unreacted 1a with a very small amount of another compound (89) Wallow, T. I.; Goodson, F. E.; Novak, B. M. Organometallics 1996, 15, 3708.

Ortho-Palladated Phenol Derivatives

Organometallics, Vol. 20, No. 13, 2001 2711

(detected by 1H NMR) that could be the expected COinserted species. 2b is partially carbonylated to give a 40:60 mixture of 2b and a compound which is probably the compound [Pd{C(O)C6H4O[C(O)Me]-2}I(bpy)]. An increase in either the reaction time or the temperature did not change the 40:60 ratio of the mixture. The palladated acrylic acid ester does not react at all with CO under our conditions. We conclude that the reactivity of our compounds toward CO insertion is dependent mainly on the nature of the ortho OR group, the reactivity order being OH . OC(O)Me > OC(O)CHdCH2. Complex 4a reacts with bpy and Tl(OTf) to give the cationic aroyl complex [Pd{C(O)C6H4OH-2}(bpy)(PPh3)]OTf (6a). These carbonylated compounds are characterized by the presence in their 1H NMR spectra of a signal at ca. 8.6 ppm, corresponding to the aryl proton ortho to the carbonyl group (see Experimental Section). The only previously isolated aroylpalladium complexes derived from carbonylation of arylpalladium derivatives are of two kinds: trans-[Pd{C(O)C6H4R-4}XL2] (R ) C6H4PdI(PEt3)2, PdI(PEt3)2, X ) I, L ) PEt3;57 R ) H, X ) Br, L ) PPh3,51,52 X ) I, L ) PCy3, PMe2Ph53 PMePh254) and [Pd{C(O)C6H4R-4}(µ-X)L]2 (R ) H, Me, L ) PPh3, X ) I;56 R ) H, L ) PBu3, X ) Cl55). We have recently reported the complexes [Pd{C(O)C6H4R2}IL2] (R ) NH2, NdCHPh, L2 ) 2 PR3, bpy) and some of their derivatives [Pd{C(O)C6H4NH2-2}L2]OTf.2 Therefore, these complexes and those reported here are the products of the first carbonylation reactions of functionalized aryl palladium complexes and also the first not containing phosphines as ligands. Reactions with Isonitriles. The addition of 2ROC6H4I (R ) H, C(O)Me) to a mixture of “Pd(dba)2” and the isonitrile R′NC (R′ ) C6H3Me2-2,6 (Xy), tBu) in toluene yields the isonitrile-inserted complexes trans[Pd{C(dNR′)C6H4OR-2}I(CNR′)2] (R ) H, R′ ) Xy (7a), tBu (7a*); R ) C(O)Me, R′ ) Xy (7b), tBu (7b*)) (Scheme 3). Complex 7b* was obtained impurified by dba but was prepared using a different method (see below). Instead of the required 3:1:1 molar ratio of reagents R′NC:2ROC6H4I:Pd, an excess of the arene and, in the case of 7a and 7a*, substoichiometric amounts of the isonitrile were used (3.2:1:2 (7a), 1.2:1:2 (7a*), 1.2:1:3 (7b)). When these reactions were carried out with the stoichiometric ratio R′NC:Pd, it was not possible to isolate complexes 7a and 7a*. The homologous complex using tBuNC and 2-CH2dCHC(O)OC6H4I seems to be in the mixture obtained in the corresponding reaction, as indicated by the NMR spectra, but it could not be isolated as an analytically pure compound, nor could the analogous complex with XyNC be obtained. The reaction between isonitriles and Pd(0) complexes have been shown to give “Pd(CNtBu)2” (eq 1).90

Scheme 3

/3“Pd(R)X” (3)

CH2CO2Me, X ) Cl) but not insertion products.91 Otsuka showed that similar complexes with R ) CH2Ph, X ) Br, I could be isolated by reacting “Pd(CNtBu)2” with XR but with X ) Cl the complex [Pd{C(dNtBu)CH2Ph}Cl(CNtBu)]2 was obtained.72 Similarly, the reaction of “Pd(CNtBu)2” with trans-BrCHdCHCO2Me gave [Pd{C(dNtBu)CHdCHCO2Me}Br(CNtBu)]2. In our case, such dimeric complexes were not obtained. We assume that the resulting [Pd(R)I(CNR′)2] (or the corresponding dimeric complex) quickly decomposes to give 7a or 7a* and some polymeric complex (eq 3) that could be responsible of the formation of the mixture observed when using the 3:1 stoichiometric amount of the isonitrile. When R ) C(O)Me, X ) I, and R′ ) Xy, the intermediate [Pd(R)I(CNR′)2] would be stable and could react with more isonitrile to give 7b. Insertion reactions of isonitriles with organopalladium complexes have been widely studied, but the above-mentioned work of Otsuka72 is the only precedent of the method we describe here. However, as already mentioned, the results are different, and the complexes involved are alkyl instead of aryl palladium complexes. Iminoacyl and -aroyl palladium complexes have been obtained (i) by reacting isonitriles with

Reactions between acyl, aroyl, and alkyl chlorides and “Pd(CNtBu)2” give the complexes [Pd(R)X(CNtBu)2] (eq 2; R ) MeC(O), PhC(O), (CH2)2CO2Et, CH(Ph)CO2Et,

(90) Otsuka, S.; Nakamura, A.; Tatsuno, Y. J. Am. Chem. Soc. 1969, 91, 6994. (91) Otsuka, S.; Nakamura, A.; Yoshida, T.; Naruto, M.; Ataka, K. J. Am. Chem. Soc. 1973, 95, 3180.

“Pd(dba)2” + 2R′NC f “Pd(CNR′)2”

(1)

“Pd(CNR′)2” + RX f [Pd(R)X(CNR′)2]

(2)

[Pd(R)X(CNR′)2] f 2/3[Pd{C(dNR′)R}X(CNR′)2] + 1

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Organometallics, Vol. 20, No. 13, 2001

alkyl,45,64,67,70,72,78,83,84,92-94 aryl,4,45,57,76,78,85,93,95-97 alkynyl,67,71,74,98 or other organopalladium complexes68,72,73,99 (ii) via a transmetalation reaction involving an organosodium68 or organomercury compound100 and a palladium isonitrile complex, or (iii) by thermal rearrangement of an organo(isonitrile)palladium complex.101-103 Complex 7a or 7b* can also be prepared by ligand displacement from 2a or 2b and XyNC or tBuNC, respectively, in an 1:3 molar ratio. The bpy ligand is substituted by two isonitriles, and a third isonitrile inserts into the Pd-C bond (Scheme 3). This method complements the previous one, since complex 7b* can now be obtained as a pure compound. However, when 2b is reacted with XyNC in a 1:3 molar ratio, the isonitrile inserts into the C-Pd bond but does not replace bpy, giving complex 8b (see below). Most of the many reported iminoaroyl palladium complexes obtained by insertion of an isonitrile into a C-Pd bond have some additional phosphorus, nitrogen, oxygen, or sulfur donor ligand(s). The only exceptions are the complexes [Pd{µ-C(dNR′)R}X]2 (R ) C6F5, R′ ) Me, p-tolyl, X ) halide),104 [Pd{µ-C(dNR′)R}XL] (R ) C6F5, R′ ) Me, X ) Cl, L ) MeNC;101 R ) R′ ) Ph, p-MeOC6H4, X ) Cl, L ) RNC),100 and [Pd{C(dNR′)R}Cl(CNR′′)] (R ) 2-C6H4CH2NMe2, R′ ) p-MeC6H4, R′′ ) tBu)96 and the doubly inserted complex [Pd{{C(dNR′)}2R}Cl(CNR′)2] (R ) 2-C6H4N2Ph, R′ ) C6H11).97 The complexes 7 thus represent a new type of iminoaroyl palladium complex. When complexes 2a,b react with R′NC in a 1:1 ratio, the bpy ligand is not displaced by the isonitrile, which inserts into the corresponding aryl-palladium bond to give the iminoaroyl palladium derivatives [Pd{C(dNR′)C6H4OR-2}I(bpy)] (R ) H, R′ ) Xy (8a), tBu (8a*); R ) C(O)Me, R′ ) Xy (8b)). As mentioned above, complex 8b is obtained even if an excess of the isonitrile is used. The only known complexes related to 8 are [Pd{C(dNR′)R}X(L2)], where R ) Me, R′ ) Xy, tBu, CH2tosyl, X ) Cl, and L2 ) bpy, phen;64 they thus represent a new type of iminoaroyl palladium complexes. In an attempt to prepare the doubly inserted complex [Pd{{C(dNXy)}2C6H4OH-2}(CNXy)(bpy)]+, we reacted 7a with bpy in the presence of Tl(OTf), which however led instead to the substitution of one isonitrile and the (92) Campora, J.; Hudson, S. A.; Massiot, P.; Maya, C. M.; Palma, P.; Carmona, E.; Martinez Cruz, L. A.; Vegas, A. Organometallics 1999, 18, 5225. (93) Yamamoto, Y.; Tanase, T.; Yanai, T.; Asano, T.; Kobayashi, K. J. Organomet. Chem. 1993, 456, 287. (94) Otsuka, S.; Nakamura, A.; Yoshida, T. J. Am. Chem. Soc. 1969, 91, 7196. (95) Zografidis, A.; Polborn, K.; Beck, W.; Markies, B. A.; van Koten, G. Z. Naturforsch., B 1994, 49, 1494. (96) Yamamoto, Y.; Yamazaki, H. Inorg. Chim. Acta 1980, 41, 229. (97) van Baar, J. F.; Klerks, J. M.; Overbosch, P.; Stufkens, D. J.; Vrieze, K. J. Organomet. Chem. 1976, 112, 95. (98) Takei, F.; Yanai, K.; Onitsuka, K.; Takahashi, S. Chem. Eur. J. 2000, 6, 983. (99) Vicente, J.; Saura-Llamas, I.; Turpı´n, J.; Ramı´rez de Arellano, M. C.; Jones, P. G. Organometallics 1999, 18, 2683. (100) Crociani, B.; Nicolini, M.; Richards, R. L. J. Organomet. Chem. 1976, 104, 259. (101) Uso´n, R.; Fornie´s, J.; Espinet, P.; Lalinde, E.; Jones, P. G.; Sheldrick, G. M. J. Chem. Soc., Dalton Trans. 1982, 2389. (102) Uso´n, R.; Fornie´s, J.; Espinet, P.; Lalinde, E. J. Organomet. Chem. 1983, 254, 371. (103) Uso´n, R.; Fornie´s, J.; Espinet, P.; Pueyo, L.; Lalinde, E. J. Organomet. Chem. 1986, 299, 251. (104) Uso´n, R.; Fornie´s, J.; Espinet, P.; Lalinde, E.; Garcı´a, A.; Jones, P. G.; Meyer-Ba¨se, K.; Sheldrick, G. M. J. Chem. Soc., Dalton Trans. 1986, 259.

Vicente et al. Scheme 4

iodide by bpy to form the cationic complex [Pd{C(dNXy)C6H4OH-2}(CNXy)(bpy)]OTf (9). It is noteworthy that bpy replaces XyNC, whereas this ligand replaces bpy in complex 2a to give 7a. We are not aware of the existence of any complex related to 9. We have attempted the coinsertion of CO and R′NC, and thus, we have (i) reacted the CO-inserted complex 5a with R′NC in a 1:2 ratio, whereupon only displacement of the bpy ligand occurs, giving trans-[Pd{C(O)C6H4OH-2}I(CNR′)2] (R′ ) Xy (10a), tBu (10a*)), and (ii) reacted these complexes with further R′NC in the presence of Tl(OTf), whereby only the cationic complexes [Pd{C(O)C6H4OH-2}(CNR′)3]OTf (R′ ) Xy (11a), tBu (11a*)) were obtained (Scheme 3). In an attempt to prepare a trinuclear complex such as A (Scheme 4) by reaction of 7a with Pd(OAc)2 in a 2:1 molar ratio, exploiting the acidity of the phenolic proton, we obtained instead an easily separable mixture of [PdI2(CNXy)2] and the tetrameric [Pd{κ2(C,O)-µ2(O)C(dNXy)C6H4O-2}(CNXy)]4 (12). Therefore, although the expected acid-base reaction took place, the resulting “naked” Pd(II) removed the iodo and one isonitrile ligand from each molecule of 7a, giving [PdI2(CNXy)2]. The structure of 12 has been confirmed by X-ray diffraction, as shown below. Spectroscopic Properties. The 1H NMR signal corresponding to the OH group in complex 1a or 2a appears as a singlet at 4.99 or 5.82 ppm, respectively. This signal is shifted to much higher frequency in the CO-inserted complexes (4a, 9.72 ppm; 6a, 10.08 ppm; 5a, 10.25 ppm) or still higher in the isonitrile-inserted complexes (7a, 13.66 ppm; 7a*, 15.89 ppm; 8a*, 13.90 ppm; 9a, 13.36 ppm). These changes may be associated with to the deshielding caused by an intramolecular hydrogen bond between the OH group and the carbonyl oxygen or the imine nitrogen, which would result in the formation of a six-membered ring (Chart 1). This has been confirmed by X-ray diffraction studies carried out for 5a, 7a, and 9a (see below). Complexes 10a, 10a*,

Ortho-Palladated Phenol Derivatives

Figure 1. Thermal ellipsoid plot of complex 5a (50% probability levels) with the labeling scheme. Selected bond lengths (Å) and angles (deg): Pd-C(1), 1.998(10); Pd-N(22), 2.102(8); Pd-N(12), 2.159(7); Pd-I, 2.5883(9); C(1)-O(1), 1.202(11); C(1)-Pd-N(22), 95.4(3); N(22)-PdN(12), 78.4(3); C(1)-Pd-I, 87.7(3); N(12)-Pd-I, 98.4(2). Chart 1

11a, and 11a* show a singlet at 10.79, 10.78, 10.31, and 10.42 ppm, respectively, shifts very similar to those of 4a, 6a, and 5a. In consequence, we propose a hydrogen bond between the OH and the carbonyl oxygen in these complexes. In o-hydroxyacetophenone the OH proton resonance appears at 12.25 ppm. We have reported similar intramolecular hydrogen bonding in trans-[Pd{C(O)C6H4NH2-2}I(PMe3)2] between the aroyl oxygen and one of the ortho NH2 protons.2 The band assignable to ν(OH) in complexes with R ) H is clearly observed only in the case of 2a. In all other cases it is weak and broad and has not been assigned. Those complexes with R ) C(O)Me show one band from ν(CO) in the narrow range 1768-1746 cm-1, 17-39 cm-1 lower than in C6H4{OC(O)Me}-I-2 (1785 cm-1). This is probably because of the lower electron-withdrawing effect on the aryl ligand of the ortho groups in the complexes (“PdIL2” in 1b, 2b, 3b; “{C(dNR′)}PdIL2” in 7b, 7b*, 8b) compared to that of the iodine substituent in the starting compound. Similarly, complexes 1c and 3c show ν(CO) bands at lower frequencies (1726 and 1734 cm-1, respectively) than the corresponding one in the iodoarene C6H4OC(O)CHdCH2-I-2 (1745 cm-1). The band corresponding to ν(CtN) appears in the region 2224-2190 or 2192-2158 cm-1 for complexes containing tBuNC or XyNC, respectively. The band corresponding to ν(CdN) appears in a wide range (1642-1536 cm-1). The factor with the greatest effect on the frequency of this band is the nature of the group R, because, other groups being equal, ν(CdN)C(O)Me ν(CdN)H ) 30-78 cm-1. Certainly, the intramolecular O-H‚‚‚N hydrogen bonding must be responsible for this effect (ν(CdN)C(O)Me ) 1636-1586 cm-1; ν(CdN)H ) 1572-1536 cm-1). As expected,64 ν(CdN)tBu > ν(CdN)Xy for the same R but the difference is lower than that

Organometallics, Vol. 20, No. 13, 2001 2713

Figure 2. Thermal ellipsoid plot of one of the two independent molecules of the complex 7a (30% probability levels) with the labeling scheme. Selected bond lengths (Å) and angles (deg): Pd-C(3), 1.979(3); Pd-C(4), 1.982(3); Pd-C(1), 2.044(3); Pd-I, 2.7009(5); O-C(12), 1.350(4); N(2)-C(1), 1.282(4); N(3)-C(3), 1.147(4); N(4)-C(4), 1.146(4); C(3)-Pd-C(1), 91.32(11); C(4)-Pd-C(1), 87.61(11); C(3)-Pd-I, 91.22(8); C(4)-Pd-I, 89.74(8); C(1)-N(2)C(21), 123.8(2); C(3)-N(3)-C(31), 169.5(3); C(4)-N(4)C(41), 179.0(3); N(3)-C(3)-Pd, 174.6(3); N(4)-C(4)-Pd, 177.5(3).

Figure 3. Thermal ellipsoid plot of the complex 7b (30% probability levels) with the labeling scheme. Selected bond lengths (Å) and angles (deg): Pd-C(3), 1.954(5); Pd-C(4), 1.977(5); Pd-C(1), 2.058(5); Pd-I, 2.7121(6); O(1)-C(17), 1.365(7); O(1)-C(12), 1.407(6); O(2)-C(17), 1.193(6); N(2)-C(1), 1.259(6); N(3)-C(3), 1.157(5); N(4)-C(4), 1.139(5); C(3)-Pd-C(1), 90.0(2); C(4)-Pd-C(1), 87.7(2); C(3)-Pd-I, 91.60(15); C(4)-Pd-I, 90.62(15); C(17)-O(1)C(12), 115.4(4); C(1)-N(2)-C(21), 124.0(5); C(3)-N(3)C(31), 172.8(6); C(4)-N(4)-C(41), 174.7(5); N(3)-C(3)-Pd, 178.0(5); N(4)-C(4)-Pd, 177.7(5).

ascribable to R (16-62 cm-1), giving the following order of ν(CdN): 7b* > 7b > 7a* > 7a; 8b > 8a* > 8a. X-ray Crystal Structures of Complexes 5a, 7a, 7b, 8b, 9a, and 12. The structures of these complexes show the usual square-planar arrangement about the palladium atom (5a (Figure 1), 7a (Figure 2), 7b (Figure 3), 8b (Figure 4), 9a (Figure 5) and 12 (Figure 6)). The crystal structure of 7a involves two independent but essentially similar molecules (rms deviation of all non-H atoms 0.11 Å). In those complexes with bpy, the geometry is distorted because of the small bite angle of this ligand. The different Pd-I and Pd-N bond distances can be used to order the trans influence of some ligands. Thus, the Pd-I bond distances (in Å) are

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Organometallics, Vol. 20, No. 13, 2001

Figure 4. Thermal ellipsoid plot of the complex 8b (50% probability levels) with the labeling scheme. Selected bond lengths (Å) and angles (deg): Pd-C(1), 1.994(4); Pd-N(1), 2.114(3); Pd-N(2), 2.153(3); Pd-I, 2.5904(4); N(3)-C(1), 1.267(5); C(42)-O(1), 1.424(5); C(47)-O(2), 1.190(6); C(47)-O(1), 1.326(6); C(1)-Pd-N(1), 95.85(14); C(1)-PdN(2), 173.12(14); N(1)-Pd-N(2), 77.28(12); C(1)-Pd-I, 88.89(10); N(1)-Pd-I, 175.07(9); N(2)-Pd-I, 97.98(9); C(1)-N(3)-C(31), 126.6(3).

Figure 5. Thermal ellipsoid plot of the cation of complex 9a (30% probability levels) with the labeling scheme. Selected bond lengths (Å) and angles (deg): Pd-C(40), 1.926(2); Pd-C(7), 2.017(2); Pd-N(22), 2.0739(18); PdN(32), 2.1173(19); O(1)-C(2), 1.348(3); N(1)-C(7), 1.283(3); C(40)-Pd-C(7), 85.68(9); C(7)-Pd-N(22), 96.27(8); C(40)-Pd-N(32), 99.40(9); N(22)-Pd-N(32), 78.98(7); C(7)N(1)-C(11), 124.1(2); C(40)-N(2)-C(41), 172.6(2); N(2)C(40)-Pd, 173.8(2).

2.5883(9) (5a), 2.7009(5) (7a), 2.7121(6) (7b), and 2.5904(4) (8b). Therefore, the order of trans influence is bpy , C(dNXy)C6H4OC(O)Me-2 < C(dNXy)C6H4OH-2. The Pd-N bond distances (in Å) in bpy complexes are as follows: trans to I, 2.102(8) (5a) and 2.114(5) (8b); trans to C(dO)C6H4OH-2, 2.159(7) (5a); trans to C(dNXy)-

Vicente et al.

Figure 6. Thermal ellipsoid plot of complex 12 (30% probability levels) with the labeling scheme. Hydrogen atoms are omitted for clarity. Selected bond lengths (Å) and angles (deg): Pd-C(10), 1.926(5); Pd-C(20), 2.004(4); Pd-O(1), 2.052(3); Pd-O(1)#1, 2.195(3); O(1)-Pd#2, 2.195(3); C(10)-N(1), 1.155(6); C(10)-Pd-C(20), 96.0(2); C(20)-Pd-O(1), 84.99(16); C(10)-Pd-O(1)#1, 93.68(16); O(1)-Pd-O(1)#1, 85.09(13); C(32)-O(1)-Pd, 111.1(3); C(32)-O(1)-Pd#2, 123.1(3); Pd-O(1)-Pd#2, 122.50(14); N(1)-C(10)-Pd, 170.8(4); C(10)-N(1)-C(11), 173.3(5); C(20)-N(2), 1.265(6).

C6H4OC(O)Me-2, 2.153(3) (8b). If the values for the neutral complexes are compared, the order of trans influence is I < C(dNXy)C6H4OC(O)Me-2 ≈ C(dO)C6H4OH-2. In the cationic complex 9b, the order of trans influence is XyNC < C(dNXy)C6H4OH-2. When the Pd-C(dNXy)C6H4OC(O)Me-2 bond distances in 7b (2.058(5) Å) and in 8b (1.994(4) Å) are compared, the order of trans influence is bpy < I. Therefore, from the above series we propose the following scale of trans influence: bpy < I < C(dNXy)C6H4OC(O)Me-2 ≈ C(dO)C6H4OH-2 < C(dNXy)C6H4OH-2. The aroyl and iminoaroyl C-Pd bond distances only depend on the nature of the trans ligand because the related pairs of complexes 5a (1.998(10) Å)/8b (1.994(4) Å), with bpy trans, and 7a (2.044(3) Å)/7b (2.058(5) Å), with iodo trans, have similar C-Pd bond distances. An intramolecular hydrogen bond is established between the OH group at O(2) and the carbonyl oxygen O(1) in 5a (O-H, 0.84 Å; OH‚‚‚O, 1.83 Å; O‚‚‚O, 2.559(9) Å; O-H‚‚‚O, 144.2(4)°), from the OH group to the imine N(2) nitrogen in both molecules of 7a (O-H, 0.76(3) Å; H‚‚‚N, 1.90(3) Å; 1.89(3) Å; O‚‚‚N, 2.584(3), 2.579(3) Å; O-H‚‚‚N, 151(3), 150(4)°) and from O(1)-H to N(1) in 9a (O-H, 0.84 Å; H‚‚‚N, 1.83 Å; O‚‚‚N, 2.571(3) Å; O-H‚‚‚N, 144.2(4)°) giving a six-membered ring (Chart 1). This type of interaction may reasonably be postulated as the cause of the high frequency of the 1H NMR resonance observed for the OH proton and the low frequency of the ν(CdN) band in these and related complexes (see above). The following additional nonclassical hydrogen bonds are observed: 5a,

Ortho-Palladated Phenol Derivatives

C(23)-H(23)‚‚‚O(2) with H‚‚‚O ) 2.46 Å and C H‚‚‚O ) 139°; 9a, seven H bonds to triflate and ether oxygens, of which the shortest is C(34)-H(34)‚‚‚O(2) with H‚‚‚O ) 2.45 Å, C-H‚‚‚O ) 167°. The X-ray diffraction study of 12 (Figure 6) reveals a tetrameric structure with crystallographic 4-fold symmetry, consisting of a highly distorted cubic array of alternating palladium and oxygen atoms; the nonbonded axial Pd‚‚‚O contacts along the open sides of the cube are typically long at 3.097(3) Å. A schematic representation of the structure is shown in Scheme 4. Each palladium atom displays a distorted-square-planar geometry formed with a chelating C,O iminoacylphenolato ligand, XyNC, and the oxygen atom of an adjacent fragment. The oxygen atoms are unsymmetrically bonded to two palladium atoms (Pd-O(1), 2.052(3) Å; Pd-O(1)#, 2.195(3) Å). The shorter bond distances correspond to those in the chelating ligand. A search of the Cambridge Crystallographic Database revealed only two precedents for this type of structure in palladium complexes, [Pd{κ3(C,N,O)-µ2(O)-C6H4(CHMeNdCHC6H4O-2)-2}]4105 (B)

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and [Pd{κ2(P,O)-µ(O)-Ph2P(C6H3(OH)-3-O-6}Br]4106 (C). These complexes, obtained by routes completely different from that of 12, have in common with it the presence of a chelating (E-X-Y-O)n- ligand (12, E ) C, n ) 2; B, E ) N, n ) 1; C, E ) P, n ) 1). Complex B has been found to catalyze the allylic oxidation of cyclohexene.105 Acknowledgment. We thank Direccio´n General de Investigacio´n Cientı´fica y Te´cnica (Grant No. PB971047), INTAS (Grant No. 97-166), and the Fonds der Chemischen Industrie for financial support. W.F. is grateful to the DGESIC of Spain for a grant. Supporting Information Available: X-ray crystallographic files, in CIF format, for 5a, 7a, 7b, 8b, 9a, and 12. This material is available free of charge via the Internet at http://pubs.acs.org. OM010074Z (105) Yang, H.; Khan, M. A.; Nicholas, K. M. J. Chem. Soc., Chem. Commun. 1992, 210. (106) Sembiring, S. B.; Colbran, S. B.; Craig, D. C.; Scudder, M. L. J. Chem. Soc., Dalton Trans. 1995, 3731.