Notes Synthetic Antigonadotropins.
I11
. I
H. H. Fox,laJ. T. GIBAS,H. L. LEE, ASD A . BORIS
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111a previous rcport'b we described the synthesis of some new triarylethylenes which possess marked antigonadotropin activity. The same study showed that the substitution of a 2- or 4-pyridyl group for one of the phenyl groups on C-1 resulted in the loss of activity.
loss of activity: (1) substitution of a cydoalkyl g1.0up such as cyc.lohuty1 01' c.yclopenty1 groups for oiie of 111(1 phenyl groups 011 ('-1 ; ( 2 ) bridging the t ~ v ophenyl groups attachc>dt o ("-1so as to produce a fluorene group or a dibenzocyclolicptadicrlf or a dibcnzocycloheptatriene structurci: ( 3 ) sitbstitution of a cyklopropyl group for tlic c3tIiyle1ic link t o which the three ptienyl
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I:,
HO -4' -('HpI
