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VOLUME 86, NUMBER 8 FEBRUARY 25, 2008

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COVER STORY

PHARMA EARNINGS

U.S. drugmakers had a robust 2007, but lack of new products could make for a tough 2008.

MEDICINAL POLLUTION

30

BIOTECH EARNINGS

Big firms look to rebuild their portfolios amid slowing product sales and dry pipelines that stunted 2007 results.

Scientists weigh in on how metabolized and discarded pharmaceuticals affect the environment and human health. PAGE 13

32 33

GOVERNMENT & POLICY CONCENTRATES DUST DANGER DEBATE

Recent plant explosion highlights need for tougher combustible dust controls. 36

DIVERSITY ROADBLOCKS

Workshop examines implicit bias and its effects on minority participation in academic chemistry.

DANIEL A. CROWL, CHEMICAL PROCESS SAFETY PROFESSOR, MICHIGAN TECHNOLOGICAL UNIVERSITY PAGE 33

6

NEWS OF THE WEEK MOVING ATOMS

For the first time, researchers have measured forces needed to move an atom across a surface. 7

PUBLIC ACCESS RESPONSE

U.S. senator is concerned about NIH’s mandatory policy. 7

A POTENTIAL THREAT

9

TOXIC TRAILERS

High levels of formaldehyde are found in temporary housing for hurricane victims. 9

SELF-HEALING RUBBER

Small molecules form new supramolecular networks that self-mend at room temperature. 10

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3 4 41 42 51 56

2008 WINNERS

THE DEPARTMENTS

EDITOR’S PAGE LETTERS INSIDE INSTRUMENTATION ACS COMMENT EMPLOYMENT NEWSCRIPTS

COVER: gettyimages

THIS WEEK ON

WWW.CEN-ONLINE.ORG

CHINA’S POLLUTION INSURANCE

BUSINESS

CONCENTRATES CHANGING OF THE GUARD

Kemira installs new CEO and revamps its corporate strategy. 23

AWARDS

ACETALDEHYDE ACTION

Nationwide scheme aims to help polluting companies stay in business, compensate victims. 18 20

INSIGHTS

Cope Medalist Stoddart; Cope Scholars: Bode, Burrows, Enders, Hayashi, Hsieh-Wilson, Nuckolls, Sanford, Scanlan, Sibi, and Singleton.

With tweaking, researchers turn troublesome reagent into useful synthetic tool. 10

CONCENTRATES PROTOBRANCHING

The chemistry and materials of dentistry.

BAXTER’S HEPARIN PROBLEMS

Citing terrorism concerns, NRC panel urges phaseout of some 5,000 radionuclide radiation devices used in medicine and research.

7

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Search continues for the cause of adverse reactions to firm’s blood thinner. 8

SCIENCE & TECHNOLOGY Mechanism that stabilizes branched alkanes is believed to stabilize linear alkanes as well.

DESULFURIZING HEAVY CRUDE

Polycyclic aromatic hydrocarbons such as anthracene interfere with catalytic removal of sulfur. 8

38 39

CHEMICAL EARNINGS

Companies emphasized overseas growth in 2007 to counter U.S. economic weakness.

MATTER MANIPULATION

Watch a video depicting scientists at IBM moving individual atoms and measuring forces involved. PLUS: See auxiliary information on the ACS Strategic Plan and join the discussion.

C E N E AR 8 6 (8 ) 1–56 • ISSN 0009 - 23 47

JENN Y HUNT ER/IBM

QUOTE OF THE WEEK “Who would think that sugar is explosive? You use it all the time.”