ROOH REVIEWS not? The electron density maps which were introduced in the first edition have been replaced by Jorgensen-style orbital diagrams. Good problems are now placed not only a t the end of each chapter hut also new ones have been introduced strategically in the text. A greatly amplified "Study Guide-Solutions Manual" has been developed by the authors' colleague, Paul A. Bartlett. As before, synthetically useful chemistry is introduced rather earl" and the student is reminded f r e q ~ m t l ythnt organic chrm~stryis a lnl,oratory xrienca thnmgh preparatiw p n w dures d e n t e d wnhm the rrxt The otherwiw up-to-date integration of theory and practice, however, lapses with two totally anachronistic drawings on pages 384 and 443. The former shows an unsupported flask which contains benzene. alcohol. and a ketone rerather late and relatively cursory treatment of aromatic chemistry. In this twelve-hundred page volume, benzene appears on page 637 and aryl halides, phenols, and phenyl ethers appear on page 982-after carbohydrates. amino acids. and oroteins. Goad reasun.; r m IIP advanced fm th15d e r d prim. try, erperrally f n m the perspective of rm. purtnnce to life srlenrs students. However. the potcntlnl tenrher shmdd he prepared to deal u,irh thw orgnnmtion of the mnrerinl ao that students d d n a t get the impression that aromatic chemistry is an arcane or "advanced" tooic in oreanie . chemistrv., In cummnry. I hrliwr this texthook to he out*tnnding for ulr in n d i d , full-year urganie course for chemistry majors, engineers, and pre-medical students. The previous edition has demonstrated a gwd track record of teachability, and this carefully modified revision should he even better. Edward M. Arnett Duke University Durham, NC 27706
Fundamentals of Organlc a n d Biochemistry Miriam Maim. D. Van Nostrand Company, New York, 1980. 438 pp. Figs. and tables. 18 X 24 cm. $14.95. Malm's paperback text is intended for students in nursing, dental hygiene, nutrition, and physical therapy-the allied health seiences. Unlike some other texts aimed a t this group, the text does not have a general chemistry component. The organic section devotes much more time to nomenclature and physical properties of the main functional groups than t o synthesis and chemical properties. Most chemical reactions are written with the classical lasso method. The onlv other chemical reae-
smthesis is not mentioned. These bare hones must, therelure. Iw prca~ntedas a caterhism and rhnr is the nature irf all the rxerrisri wirh~nthctp~t.'llheilnsuersU~th~q~~rstions are given immediately in the next section so memorization rather than rationalization is the obvious intent. Not a single prohlem involving quantities is given. The student may check his or her progress a t the end of a chapter by a series of questions, hut the answers are generally one word or a t most one line and the expected answers are given a t the end of the text. There is no suggestion that anything more complex than a test tube reaction has ever been carried out in an organic laboratory. The chapter on stereoisomerism is particularly disappointing in that only 3 f'gures are shown with a 3-dimensional perspective. The pleated sheet and the a-helixare better executed. Without models the reader will he hard put t o get the necessary ideas of stereaisomerism from this text. The biochemistry is handled in better style. The reader gets more of a feeling of a complexity in biochemical systems and the cyclic nature of metabolic processes. One might expect a heavier treatment of buffers. There are no problems on pH. However, I do not feel that the simplicity of the organic section prepares the student far the ;omplexity of the role of hemoglobin, the energy transfers in the ATP-AMP svstem. the action of an enzyme, and it does not aid in an understanding of enzyme kinetics or the mechanism of oxidative phosphorylation. In fairness i t should he said that the organir ronrrnt and treatment 13 nt the ram* lewl as that of rhe rompetrtiun in this field. The hiwhemirol woicsare w t thme thnt rhe student in health-related fields need to know. Teachers of such courses will want to consider this text in selecting one to use. Leallyn 6.Clapp Bmwn University Providence. RI 02912 ~
Textbook of Blopharmaceutic Analysis Robert V. Smith and James T. Stewart, Lea 8 Febiger, Philadelphia, 1981. xii 308 pp. Figs. and tables. 26 X 18 cm.
+
$25.00.
The current direction toward the Pharm.D. degree in Colleges of Pharmacy is, because of the emphasis on clinical problems, generating a need for general textbooks describing the wide variety of modern analytical instruments available for the analysis of biological materials. The "Textbook of Biopharmaceutie Analysis" obviously falls within this province. The hook follows a logical course from defining the problem to sample preparation through the acquisition and treatment of data. Under the "Defining The Problem" heading .the authors give . an overview of the prohlems of sensitivity and selectivity, compare types of biological samples (urine, feces, blood.. etc.). as to bandline" difficultv.. and describe methods of procuring and charac-
.
A144
Journal
of Chemical Educati
~
reference materials. The chaoter covering "The Separation Step" is hell written and describes methods used for precipitation of protein, solvent extractions, etc. and introduces the chromatographic procedures (TLC, GC, HPLC) alongwith derivatization techniques. The general utility of XAD resin is illustrated. The "Measurement Step" describes the instrumentation used in pharmaceutical analysis including chromatographic methods, absorption spectroscopy (UV, Emission, Flame, Atomic Absorption, Fluorescence), electrochemical procedures, radiopharmaceuticals, immunoassay, and microbiological and enzyme analysis. Each chapter describes, using approprlat? exomples, the theory of the instrumrnt/method and illustrates the util:tvofthr in~trumcntl method in solving partickardrug metabolism and distribution oroblems. 'l'hr bouk ~sclenrlgwnttenand extremdy well rctkrrnced with current l~teraturrm a . rims. I'nrriuns of the trrt are tuodetniled fur classroom presentation but are an asset for laboratory assignments. The only criticism is the absence of clualitative and quantitative problems a t the end of appropri& chapters and the lack of answers to the questions (even though they are contained in the text). Despite these minor deficiencies, the hook warrants consideration as a text in pharmaceutical analysis courses and would be a valuable general reference hook in pharmaceutical analysis laboratories. Karl H. Schram DepaRment of Pharmaceutical Sciences College of Pharmacy University of Arizona Tucson, AZ 85721
Quantum Chemistry, R e f e r e n c e Edition John P. Lowe, Academic Press. New 559 pp. Figs. and taYork. 1978. xvi bles. 16 X 23.4 cm.
+
This well-written book covers very nicely those areas of quantum mechanics and chemistry-from fundamental t o advanced and applied-which the author has chosen to treat. The author shows a real knack for descriptions and explanations accessible to the mathematically less sophisticated reader. Especially praiseworthy is his consistent attempt, successful on the whole, always to give the wider, deeper, and qualitative significance of various mathematical theorems, results, etc. The hook will be useful to a wide range of students-both undergraduate and graduate-in quantum chemistry, advanced physical chemistry or chemical physics courses. I t may be especially valuable because of its clarity and pedagogic felicities as a background or self-study hook for students interested in modern (primarily organic) ehernistrv. As is inevitable, the range of topics treated had to be severely limited, though most heginning textbooks are somewhat more encyclopedic. The author has put his emphasis on molecular orbital methods of various levels of sophistication. This reviewer regrets the complete, or almost complete, absence of any discussion of valence bond methods, spectroscopy (including ESR and NMR), time
