The productivity of split-and-pool. The quality of parallel synthesis

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o u CAN NOW rapidly and pooling batches of microchip economically synthesize encoded microreactors that are multi-milligram quantities physically separated from one of hundreds to thousands of another, combinatorial libraries of discrete compounds. No, we discrete compounds can be rapidly haven't changed the laws of synthesized. In this directed sortphysics, just creatively ing process, compounds are "split" MicroKan" andMicroTube* reactors applied them. by electronically reading their unique ID tag - not a random statistical process. The AccuTag -100 Combinatorial Chemistry The result is the rapid synthesis of exactly one disSystem uniquely combines the advantages of both crete copy of every unique compound in the library. parallel synthesis and split-and-pool. Parallel synthesis provides multi-milligram We Have Worked Out All the Details. quantities of discrete compounds. However, it is At IRORI, we have developed a robust combination difficult to rapidly synthesize thousands of glass encapsulated microchip tags, polymer microof compounds by parallel synthesis, reactors, sorting stations, and software to provide a comeven with automation. The tradiplete turn-key solution for combinatorial chemistry. tional split-and-pool technique To Learn More, Ask for the Details. addresses this limitation, but This technology is already being used in dozens with severe consequences of pharmaceutical laboratories synthesizing thou- mixtures, or complex sands of compounds every month. To see how easy molecular encoding it is to use the AccuTag System to schemes. Now, the AccuTag synthesize multi-milligram quantiSystem solves this dilemma. ties of discrete compounds with the productivity of split-andUnique Combinatorial Process. pool, call us at 619-546-1300 The AccuTag System uses an innovative and well send you the details. process to implement a powerful form of split-andpool called "directed sorting." By splitting and E-mail: [email protected] / fax 619-546-3083 I R O R I Contact us for the locations of our international CIRCLE 7 ON READER SERVICE CARD

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