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Nov 4, 2010 - American Chemical Society. 104TH MEETING. Buffalo, N. Y., September 7 to 11, 1942. 105TH MEETING. Indianapolis, Ind., April 12 to 16, 19...
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MEETINGS FORESHADOWED

Plant Conversion Round Table T H E third annual meeting of t h e Insti­ tute of Food Technologists, t o be held in Minneapolis, Minn., from J u n e 15 to 17, will feature a round-table discussion of ways a n d means of converting idle or iidaptnhle plant production capacity to the making of products essential to war. A similar session will be held o n educa­ tional requirements of food technologists.

American Chemical Society 104TH MEETING.

Hudson Announces First Synthesis of Lactose

Buffalo, Ν . Υ., Septem­

ber 7 to 11, 1942. 105TH

MEETING.

Indianapolis,

Ind.,

April 12 to 16, 1943. 106TH

MEETING.

Minneapolis,

Minn.,

fall of 1943. LEHIGH VALLEY SECTION.

Lafayette Col­

lege, Easton, Penna., June 19, 1942. Speaker, Nelson W. Taylor, "Some Re­ cent Researches on Glass." NATIONAL

CHEMICAL E X P O S I T I O N .

Ste­

vens Hotel, Chicago, 111., November 17 to 22, 1942. NINETEENTH

NATIONAL

COLLOID

SYM­

POSIUM, Division of Colloid Chemistry. University of Colorado, Boulder, Colo., J u n e 18 to 20, 1942.

O t h e r Scientific Societies AMERICAN

ASSOCIATION

OF

C

S. HUDSON, United States Public • Health Service, m a d e the first public announcement of the synthesis of lactose at t h e 109th meeting of t h e Central Penn­ sylvania Section of t h e A M E R I C A N C H E M I ­

CAL SOCIETY held in t h e N e w Physics Building, State College, May 27. The structure of this characteristic sugar of the mammalian world has been k n o w n for some time, thanks to t h e methylation studies of Sir James Irvine and of W . N . r l a w o r t h . Lactose had never been syn­ thesized, however, until t h e recent accom­ plishment in D r . Hudson's laboratory a t Bethesda. M d . , in which work h e was assisted by W . T . Haskins and R a y m o n d Μ . Ηann. T h e difficult step in t h e process was t h e obtaining of a suitable intermediate h a v ing as i t s only free and reactive group t h e

4-hydroxyl. Strange to say, this appeared in t h e form of mannosan, t h e anhydride of mannose having 1,5- and 1,6-rings. This was first obtained by the destructive distillation of vegetable ivory obtained as waste from b u t t o n manufacture. Later, for the sake of completeness in t h e synthe­ sis, it was obtained by t h e Tanret reac­ tion of barium hydroxide on beta-phenylmannoside. M a n n o s a n h a s t h e 2,3,4-hydroxyls free. T r e a t m e n t with acetone blocks t h e a.s-2,3-hydroxyls, leaving the 4-hydroxyl as t h e only free reactive group. T r e a t m e n t with bromotetraacetylgalactose gives the desired beta-linked galac­ tose residue in t h e 4-position. T r e a t m e n t with 80 per c e n t acetic acid removed t h e acetone, leaving t h e 2,3-hydroxyls free. These a r e then acetylated by acetic a n h y ­ dride a n d pyridine. T r e a t m e n t with a mixture of acetic anhydride, glacial acetic acid, a n d sulfuric acid opens t h e 1,6-ring in t h e . a n n o s e p a r t of t h e molecule. T r e a t m e n t with hydrogen bromide gives t h e 1-bromo compound. Zinc dust is then used to remove this atom and t h e acetate group from t h e adjacent carbon, thus leaving t h e hexaacetate of lactal having a double bond in the 1,2-position of the origi­ nal mannose moiety. T r e a t m e n t with perbenzoic acid adds t w o hydroxyls, for­ t u n a t e l y in t h e configuration of glucose. Removal of t h e six acetyl groups by treat­ m e n t with sodium methjdate gives crys­ talline synthetic lactose. REPORTED BY FRANK C . W H I T M O R E

PHYSICS

TEACHERS. S t a t e College, Penna., June 25 to 2 7 . AMERICAN

INSTITUTE

ENGINEERS. 26.

OF

ELECTRICAL.

Chicago, 111., June 22 t o

AMERICAN PHYSICAL SOCIETY.

M i d - H u d s o n Section H o l d s Charter M e e t i n g At

S t a t e Col­

lege, Penna., June 25 to 27; Berkeley, Calif., July 11.

C H E M I C A L S O C I E T Y in P o u g h k e e p s i e ,

Atlantic City, N . J., J u n e 22 t o

EASTERN PHOTOELASTICITY C O N F E R E N C E .

University Club, Boston, Mass., J u n e 20. Semiannual meeting. INSTITUTE

OF

FOOD

N.

Y, M a y 19. F r a n k Η. B r u n e r was elected C h a i r m a n ; Carroll W. Griffin, ChairmanElect; Fred C. Toettcher, SecretaryT r e a s u r e r ; a n d Dorman McBurney, Coun­ cilor. Following a banquet, Per K. Frolich, President-Elect of t h e SOCIETY, addressed t h e section on " T h e R u b b e r Problem".

AMERICAN SOCIETY FOR T E S T I N G M A T E ­

RIALS. 26.

T H E charter meeting of t h e M i d Hudson Section of t h e AMERICAN

TECHNOLOGISTS.

Hotel Nicollet, Minneapolis, Minn., J u n e 15 to 17. Annual meeting. NEW E N G L A N D ASSOCIATION OF C H E M ­ ISTRY T E A C H E R S . University of New

Hampshire, Durham, N . H., August 1 1 to 14. OPTICAL SOCIETY OF AMERICA.

Massa­

chusetts Institute of Technology, C a m ­ bridge, Mass., July 20 t o 22. SOCIETY* FOR T H E PROMOTION OF E N G I ­ N E E R I N G EDUCATION. Columbia U n i ­

versity, New York, N . Y., June 27 a n d 28. Annual meeting. 1 The list of the SOCIETY'S National Officers and Directors, Editors, members of Council, Divisional and Local Section Officers, Com­ mittees, and Chapters of Student Affiliates

appears

in

CHEMICAL

AND ENGINEERING

N E W S three times a year—usually February 10, May 10, and October 10. The latest list is printed on page 601 of the May 10 issue. 750

Carroll W . Griffin, Chairman-Elect, and Per K. Frolich, Quest speaker, at the charter meeting of the M i d - H u d s o n Section C H E M I C A L

N e w officers o f M i d - H u d s o n Section. Left to right, Secretary-Treasurer Toettcher, Chairman Bruner, Councilor McBurney A N D

E N G I N E E R I N G

N E W S