Theoretical Calculation of Effects of Steric Hindrance on Rates of

14-OH, 107597-49-9; 14-OTs,107597-50-2; 1 4 d , 107597-52-4; 15,. 3564-54-3; 16, ... (7) Westheimer, F. H. In Steric Effects in Organic Chemistry; New...
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2074

J. Org. Chem. 1987,52, 2074-2082

alyzed by LSC. After the appropriate fractions were collected, LSC showed 1.1 fiCi (31%) incorporation. The exo and endo pyrophosphates ([aH]-13-OPPand [%]-14-OPP) were incubated with kaurene synthetase, using the same procedure. After the column chromatographic separation, only negligible radioactivity (