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The antibacterial action of cultures of a Pénicillium, with special reference to their use in the isolation of B. influenzae. A. FLEMING. Brit. J. Exptl. Path. 10, 226-36 (1929). — A certain type of Pénicillium produces in ordinary nutrient broth a powerful antibacterial substance. The active agent is readily filtrable and the name "penicillin" has been given to filtrates of broth cultures of the mold. Penicillin loses most of its power after 10-14 days at room temp, but can be preserved longer by neutralization. The active agent is not destroyed by boiling for a few min. but in alk. soin, boiling for 1 hr. markedly reduces the power. Autoclaving for 20 min. at 115° practically destroys it. It is sol. in ale. but insol. in ether or CHCl^. The action is very marked on the pyogenic cocci and the diphtheria group of bacilli. Many bacteria are quite insensitive, e. g., the coli-typhoid group, the influenza bacillus group and the enterococcus. The isolation of Pfeiffer's bacillus of influenza is very easy when penicillin is used. Penicillin is non-toxic to animals in enormous doses and is nonirritant. It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillinsensitive microbes. HARRIET F. HOLMES
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Drawing bused on a photograph by Karsh of Ottawa.
23:4961 CA: Vol. 23 (1929)
TOMORROW'S MILESTONES! ARE IN CA.. .TODAY! âlpxanxler Fleming's paper on penicillin—abstracted in Okemical Abstracts in 1929—ushered in a new era §|riéi&eareh, technology and medical care. Behind that great advance is a story of miraculous luck which thought a spore of the mold Pénicillium notatum to a pefil dlish in Fleming's disorderly laboratory, and Ikming's skillful, methodical pursuit of the tantalizing factor which destroyed bacteria growing on the agar. ÂÂ s ^ ^ c e continues to grow and advance through eimilaf combinations of skill and luck, the results of that adventure wiU continue to appear in Chemical Abstracts, '- Cl]^«^kml jâ3b#traê«»—-informative eximaiaaries of the majoi; new findings in chemistry and chemical engiaeei ^ : ^ continuously since 1907 Comprehensive—culled from 14,000 journals publisHed in over 150 countries and the patents of 88 offices ;^ indexed for easy retrieval %ÊM&ë$i—œany papers are abstracted within two months of publication
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Sept. 15, 1980 C&EN 67
