TOXI Division of Chemical Toxicology: Final Program, 234th ACS

Chem. Res. Toxicol. 2007, 20, 1227–1233

Announcement TOXI Division of Chemical Toxicology: Final Program, 234th ACS National Meeting, Boston, Massachusetts, August 19–23, 2007

K. S. Gates, Program Chair Other Symposia of Interest: Drug Safety (see MEDI, Tuesday) Social Event: Named Lecturer Reception, Sunday Business Meetings: Division Business Meeting, Monday; Executive Committee Meeting, Saturday

Sunday Morning BCEC—258C. DNA-Based Biomarkers A. Bryant-Friederich, Organizer 9:00—Introductory remarks 9:10—1. DNA adducts formed in vivo vs those that can be synthesized, J. Swenberg 9:45—2. DNA and RNA lesions as biomarkers of inflammation, P. C. Dedon 10:20—Intermission 10:40—3. Selective detection and quantification of DNA lesions using chemical probes, M. M. Greenberg 11:15—4. DNA damage lesions as potential biomarkers, A. C. Bryant-Friedrich

Sunday Afternoon BCEC—258C. Zebrafish in Drug Development and Chemical Toxicology Cosponsored by BIOHW P. C. Dedon, Organizer 2:00—Introductory Remarks 2:05—5. Use of zebrafish chemical genetics to find inducers of stem cells, L. I. Zon 2:45—6. Zebrafish: A predictive model for assessing drug toxicity and efficacy, P. McGrath 3:20—Intermission 3:30—7. Oxidative xenobiotic metabolism in zebrafish: The cytochrome P450 gene complement, regulation, and function, J. J. Stegeman, J. V. Goldstone, M. Jonsson, and B. Woodin 4:05—8. Zebrafish and the discovery of cancer genes, J. Lees

Sunday Evening BCEC—258C. Division of Chemical Toxicology Lecture K. Gates, Organizer 5:00—Introductory Remarks 5:05—9. Random mutations and human cancer, L. A. Loeb, J. H. Bielas, N. G. Ericson, and M. Vermulst 6:00—Reception

Monday Morning BCEC—258C. Young Investigator Session K. S. Gates, Organizer 8:15—10. How a fullerene water suspension kills bacteria: Exploring three possible mechanisms, D. Y. Lyon and P. J. Alvarez 10.1021/tx700251d CCC: $37.00  2007 American Chemical Society Published on Web 08/02/2007

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8:30—11. NMR structural studies of stereoisomeric n3-(2-hydroxy-3-buten-2-yl)-2′-deoxyuridine DNA adducts paired opposite da, S. K. Musser, I. D. Kozekov, A. A. Liudahl, R. P. Hodge, R. S. Lloyd, C. J. Rizzo, and M. P. Stone 8:45—12. Alkylation of DNA by primary diazonium ions: Determination of the basis for atom site selectivity, X. Lu and J. C. Fishbein 9:00—13. Bis-functional electrophile-induced DNA–protein crosslinks, E. M. Loecken, A. J. L. Ham, D. C. Liebler, and F. P. Guengerich 9:15—14. Direct mapping of sites of modifications in DNA by tandem mass spectrometry, G. Chowdhury and F. P. Guengerich 9:30—15. Mechanistic studies of DNA damage induced by antitumor acylfulvene, J. Gong, V. G. Vaidyanathan, and S. J. Sturla 9:45—16. Inactivation of protein tyrosine phosphatase 1B (PTP1B) by the endogenous/dietary aldehyde acrolein, D. R. Seiner, J. LaButti, and K. S. Gates 10:00—Intermission 10:15—17. Influence of AlkB on 1,N2-ethenoguanine genotoxicity and mutagenicity in E. coli, J. C. Delaney, I. D. Kozekov, A. Kozekova, C. Wong, C. L. Drennan, L. J. Marnett, C. J. Rizzo, and J. M. Essigmann 10:30—18. Lipid peroxidation biomarkers from cellular proteins, M. V. Williams, P. G. Slade, J. S. Wishnok, and S. R. Tannenbaum 10:45—19. Quantifying the spectrum of DNA, RNA, and protein adducts arising from lipid peroxidation in cells, C. E. Elmquist, M. R. Sullivan, J. L. McFaline, J. Flarakos, R. G. Liberman, P. L. Skipper, S. R. Tannenbaum, and P. C. Dedon 11:00—20. Role of S-nitrosation in contributing to tamoxifen resistance in breast cancer, K. Pant, H. SaitoBenz, J. Li, F. M. White, and S. R. Tannenbaum 11:15—21. Solution structure of the R-N7-dG aflatoxin B1 formamidopyrimidine (FAPy) adduct in duplex DNA, K. L. Brown, S. Magee, M. W. Voehler, J. Z. Deng, C. M. Harris, T. M. Harris, and M. P. Stone 11:30—22. Structural basis of DNA interchain crosslink formation by stereospecific 1,N2-dG adducts of trans4-hydroxynonenal in the 5′-CpG-3′ sequence: An NMR study, H. Huang, H. Wang, T. M. Harris, C. J. Rizzo, and M. P. Stone 11:45—23. The influence of DNA repair pathways on the toxicity and mutagenicity induced by pyridyloxobutylating agents, L. Li, A. E. Pegg, Y. Lao, S. S. Hecht, J. T. Reardon, A. Sancar, E. V. Wattenberg, and L. A. Peterson

Monday Afternoon BCEC—258C. Frontiers in Chemical Toxicology Sponsored by Chemical Research in Toxicology L. J. Marnett, Organizer 1:00—24. Frontiers in chemical toxicology: An Editor’s perspective, L. J. Marnett 1:35—25. Endogenous DNA lesions that promote aging, L. J. Niedernhofer 2:10—26. Searching for endogenous activators of the Ah receptor, B. McMillan and C. A. Bradfield 2:45—Intermission 3:00—27. Interactions between nitric oxide and cyclooxygenase signaling pathways influence the vascular side effects of NSAIDs, V. O’Donnell 3:35—28. PBPK modeling, a tool for low-dose toxicology and individual effect assesment, P. J. van Bladeren and I. M. Rietjens 4:10—29. Protein modifications as biomarkers of oxidative stress and chemical toxicity, D. C. Liebler, S. G. Codreanu, H.-Y. Kim, M. E. Szapacs, A. Vila, and N. A. Porter

Monday Evening BCEC—Exhibit Hall C. Sci-Mix K. S. Gates, Organizer 8:00–10:00—36, 39–41, 43, 60–61, 65–66, 68, 72, 74–75, 78, 84, 96, 109–111, 113–114, and 118. See subsequent listings.

Tuesday Morning Drug Safety Sponsored by MEDI, Cosponsored by TOXI S. Ashwell and P. Galatsis, Organizers 9:00—Introductory remarks

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9:10—222. Evaluation of reactive metabolites in pharmaceutical discovery and development. S. D. Nelson 9:50—223. Bioactivation and drug design: Challenges in predicting the occurrence of idiosyncratic adverse drug reactions in early discovery, A. S. Kalgutkar 10:30—224. Predicting the toxicological consequences of drug-derived reactive metabolites: Nitric oxide synthase as a model, Y. Osawa 11:10—225. Modeling and informatics support for safety and metabolism studies in early drug discovery projects, S. Boyer 11:50—Concluding remarks

Tuesday Afternoon BCEC—258C. Drug Safety Cosponsored by MEDI F. P. Guengerich and N. A. Meanwell, Organizers 2:00 — Introductory remarks 2:05 —30. Understanding idiosyncratic drug reactions in animal models and humans, J. A. Uetrecht 2:40 —31. Gastrointestinal toxicity as a contributor to hepatotoxicity associated with a p38 R-kinase inhibitor, H. Hamadeh 3:15 —32. Drug hypersensitivity reactions: Mechanisms of pseudoallergic and infusion reactions, T. T. Kawabata 3:50 —33. Role of the innate immune system in drug-induced liver injury, C. Ju, Q. You, M. Holt, L. Cheng, and L. R. Pohl 4:25 —34. The influence of inflammatory stress on drug hepatotoxicity, R. A. Roth

Tuesday Evening BCEC—204 A/B. Poster Session and Awards K. S. Gates, Organizer 6:00–10:00 35. Kinetics and characterization of oxaliplatin–DNA adduct formation in naked DNA and cancer cells using accelerator mass spectrometry, S. S. Hah, R. A. Sumbad, K. W. Turteltaub, and P. T. Henderson 36. A rule-based method for comprehensive risk assessment of the mutagenic potential of drugs, C. Hasselgren Arnby, L. Carlsson, C. Gavaghan, and S. Boyer 37. Estrogen sulfotransferase inhibition modulates estradiol in human mammary cell systems, R. Y. Meyer and R. S. King 38. Nitrogen mustard-induced cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to its DNA substrate, R. L. Loeber, M. Goggin, D. R. Quirk Dorr, A. E. Pegg, and N. Tretyakova 39. A survey of RNA damage products in the SJL mouse model of inflammation, B. Pang, J. L. McFaline, M. R. Sullivan, C. E. Elmquist, and P. C. Dedon 40. Aldo-keto reductase 1C3 regulates prostaglandin signaling in breast cancer, M. C. Byrns, S. H. Lee, L. Duan, I. A. Blair, and T. M. Penning 41. Chemical properties of malondialdehyde nucleoside adducts and their amino acid crosslinks, J. Szekely, C. J. Rizzo, and L. J. Marnett 42. Synthesis of and mechanisms of DNA damage by 3-cyclopropyl-1,2,4-benzotriazine 1,4-dioxide, U. Sarkar and K. S. Gates 43. Drug metabolism in 3-D perfused microreactor liver cultures, J. Liu, W. Inman, S. Karakattu, M. Bokayza, K. Domansky, K. Hoffmaster, L. G. Griffith, and S. R. Tannenbaum 44. E. coli DNA polymerase I catalyzed incorporations of dATP and dGTP opposite N2-(7,8,9,10tetrahydrobenzo[a]pyren-10-yl)-2′-deoxyguanosine occur by different mechanisms, A. S. P. Gowda, J. Krzeminski, S. Amin, and T. E. Spratt 45. Development of an in vitro model for the study of drug-induced bile acid synthesis and transport dysfunction in a 3-D tissue engineered liver microreactor culturing system, J. R. L. Vidales, J. Liu, J. N. Kim, S. Karackattu, M. Bokayza, K. Hoffmaster, S. R. Tannenbaum, and L. G. Griffith 46. A synthetic nucleoside probe that discerns a DNA adduct from unmodified DNA, J. Gong and S. J. Sturla 47. Acute toxicity (LD50) modeling utilizing fragmental QSAR, similarity analysis and reliability of prediciton, P. Japertas, R. Didziapetris, and A. Petrauskas 48. An LC-ESI-MS/MS technique for quantifying polar oxidized guanine nucleotides from DNA digests, P. G. Slade, J. S. Wishnok, and S. R. Tannenbaum 49. Analysis of 8-oxo-2′-deoxyguanosine in human bronchoalveolar dells by immunoaffinity liquid chromatography/mass spectrometry, D. Mangal, S. H. Lee, J. H. Park, T. M. Penning, and I. A. Blair

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50. Benzo[a]pyrene-7,8-dihydrodiol produces reactive oxygen species via the Aldo-Keto Reductase (AKR) pathway in A549 cells: Involvement of BP-mediated redox cycling and alteration in redox status, J. H. Park, K. A. Tacka, and T. M. Penning 51. Bulge migration of the malondialdehdye OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene, Y. Wang, S. Selch, L. J. Marnett, and M. P. Stone 52. Bypass of dG-AAF by human polymerase ι: Molecular dynamics studies, K. P. Donny-Clark, L. Wang, R. Shapiro, and S. Broyde 53. Characterization of a novel glutathione adduct from arachidonic acid metabolism, K. Rangiah, S. H. Lee, A. Y. Wehr, and I. A. Blair 54. Characterization of DNA adducts formed by3,5-dimethylaniline, L. Cui, J. Flarakos, L. J. Trudel, H. P. Sun, R. G. Liberman, J. S. Wishnok, P. L. Skipper, and S. R. Tannenbaum 55. DNA-Binding by analogs of the left-half of azinomycin: A minimal DNA-intercalating structure, J. Szekely, H. Zang, M. Shipman, and K. S. Gates 56. Computational analysis of the lesion recognition mechanism of formamido-pyrimidine DNA glycosylase, K. Song, C. De los Santos, A. P. Grollman, and C. L. Simmerling 57. Correlation between mutation, gene expression and DNA adduct formation in human lymphoblast cells dosed with benzo[a]pyrene diol epoxide, C. Ceailles, W. Luo, W. Fan, L. P. Zhao, H. Zarbl, and P. Vouros 58. Correlative study of heavy metal levels in rat tissues by STEM coupled EDAX elemental mapping and ICP-MS spectroscopy following chronic exposure to low levels of cadmium CdCl2, B. A. Wilson 59. Covalent crosslinking of small-molecule antielectrophiles to proteins by 4-oxo-2-nonenal, L. M. Sayre and X. Zhu 60. Defining the spectrum of protein carbonyls formed in cytochrome C by peroxidation of linoleic acid, J. Son, M. V. Williams, J. S. Wishnok, S. R. Tannenbaum, and P. C. Dedon 61. DNA polymerase V allows bypass of toxic guanine oxidation products in vivo, W. L. Neeley, S. Delaney, Y. O. Alekseyev, D. F. Jarosz, J. C. Delaney, G. Walker, and J. M. Essigmann 62. DNA sequence effect on the conformation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the recognition sequence of the NarI restriction enzyme, F. Wang, C. E. Elmquist, J. S. Stover, C. J. Rizzo, and M. P. Stone 63. Comparison between the base eversion of 8OG:C and G:C, A. J. Campbell, A. P. Grollman, and C. L. Simmerling 64. DNA–protein cross-links between guanine and lysine depend on the mechanism of oxidation, X. Xu, J. G. Muller, and C. J. Burrows 65. Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: Enhanced mobility in TGT explains conformational heterogeneity, more flexible bending and greater nucleotide excision repair susceptibility, Y. Cai, N. E. Geacintov, and S. Broyde 66. Effect of sequence context on rate and yield of interstrand crosslinks generated by abasic sites in duplex DNA, D. R. Seiner, S. Dutta, and K. S. Gates 67. Enzymatic modulation of protein tyrosine phosphatase inactivation by H2O2: Phosphoryl transfer to produce peroxymonophosphate, J. LaButti and K. S. Gates 68. Formation of 2′-deoxyguanosine adducts from 12(S)-hydroperoxyeicosatetraenoic acid, S. H. Lee, C. Mesaros, and I. A. Blair 69. Incorporation of nucleoside triphosphates opposite stereoisomeric R and S N3-(2-hydroxy-3-buten-2-yl)2′-deoxyuridine adducts by the Sulfolobus solfataricus DNA polymerase dpo4, W. Xu, R. P. Hodge, R. S. Lloyd, M. Egli, and M. P. Stone 70. Genomic approaches to understanding cellular determinants of DNA damage, S. S. Kalinga, R. C. Fry, and P. C. Dedon 71. Global proteomic analysis of zebrafish plasma, I. R. Babu, W. Goessling, L. I. Zon, J. S. Wishnok, and S. R. Tannenbaum 72. Glutathione concentration and the aerobic fate of the C3′-thymidinyl radical in DNA, R. A. Zaidi and A. C. Bryant-Friedrich 73. Human akrs display quinone reductase activity with pah o-quinones, C. A. Shultz, A. M. Quinn, and T. M. Penning 74. Identification of covalent DNA adducts in vitro from bioactivation of pentachlorophenol, V. G. Vaidyanathan, P. W. Villalta, and S. J. Sturla 75. Identification of nitrated proteins from iNOS-induced macrophages using biotin labeling and capture, J. R. Seal, J. S. Wishnok, and S. R. Tannenbaum 76. Identification of quinol-thioether adducted proteins excreted in the urine after I.V. administration of 2-(glutathion-S-yl)HQ in Long-Evans rats, M. T. Labenski, A. A. Fisher, G. Tsaprailis, T. Monks, and S. S. Lau 77. Implications for the existence of a heptasulfur linkage in natural o-benzopolysulfanes, A. Mahendran, D. Aebisher, E. M. Brzostowska, N. Sawwan, R. Ovalle, and A. Greer

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78. Planar chirality due to a polysulfur ring in natural pentathiepin cytotoxins. Implications of planar chirality for enantiospecific biosynthesis and toxicity, A. Mahendran, E. M. Brzostowska, M. Paulynice, R. Bentley, and A. Greer 79. Synthesis of sulfur-substituted quinones from the oxidation of 5-methyl-4-mercapto-catechol and 5-methyl3,4-dimercapto-catechol, A. Mahendran, D. Aebisher, A. Castillo, J. F. Liebman, and A. Greer 80. Withdrawn 81. Withdrawn 82. Influence of guanine oxidation potential on DNA–protein crosslinking reactions, E. D. A. Stemp, A. Estonactoc, A. Madison, J. Scala, C. E. Ochoa, K. Schaefer, and K. Kurbanyan 83. Inhibitory targets of fluoroquinolone antibiotics in the photosynthetic electron transport chain: SAR modeling analysis and in vitro binding studies, L. Aristilde and G. Sposito 84. Insights into the determinants of the quantity and chemistry of sequence-selective guanine oxidation in DNA, Y. Margolin, V. Shafirovich, N. E. Geacintov, and P. C. Dedon 85. Intracellular arylamine N-acetyltransferase 1 (NAT1) is inactivated by the 4-nitroso metabolite of the tobacco smoke component, 4-aminobiphenyl, P. E. Hanna, L. Liu, and C. R. Wagner 86. Irradiation of retinol in ethanol with UVA light: Formation of photodecomposition products, reactive oxygen species, and lipid peroxides, Q. Xia, J. J. Yin, S.-H. Cherng, J. P. Freeman, H. Yu, M. D. Boudreau, W. G. Wamer, and P. P. Fu 87. LC-MS identification of toxic alkaloids from fungi in the family Clavicipitaceae, M. S. Torres, A. P. Singh, N. Vorsa, and J. F. White 88. LC-MS/MS analysis of nanoparticle-induced oxidative DNA damages, H. Hong and Y. Wang 89. Mass spectrometric studies on the modification of cytochrome c by HNE, L. M. Sayre and X. Tang 90. Mechanism of etheno adduct formation from the reaction of lipid peroxidation products with deoxyguanosine, K. V. Petrova, I. D. Kozekov, D. F. Stec, S. T. Duncan, and C. J. Rizzo 91. Mechanistic studies on antitumor properties of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide analogues, V. Junnotula, K. Gates, B. Soland, A. Marin, R. Villar, A. Burguete, E. Vicente, S. Perez-silanes, I. Aldana, and A. Monge 92. Methylated-bay region and fjord-region PAH o-quinones form mono- and bis-conjugates with N-acetylL-cysteine and glutathione, C. A. Shultz, D. Mangal, S. R. Gopishetty, R. G. Harvey, I. A. Blair, and T. Penning 93. Methylglyoxal-induced covalent modifications of proteins: Is there any correlation with diabetic complications? Y. Gao and Y. Wang 94. Mutagen/nonmutagen classification of diverse and structurally homogenous chemicals using calculated molecular descriptors: A hierarchical approach, D. Mills, S. C. Basak, D. M. Hawkins, and B. D. Gute 95. Use of theoretical descriptors in predicting aryl hydrocarbon (Ah) receptor binding affinity of dibenzofurans: A hierarchical QSAR approach, D. Mills and S. C. Basak 96. Novel modification of amyloid β-peptides by metal-catalyzed oxidation, T. Oe, K. Inoue, C. Mesaros, C. O. Garner, B. L. Ackermann, and I. A. Blair 97. Nucleotide pool as a target for nitrosative deamination during inflammation, V. Dendroulakis, W. M. Deen, and P. C. Dedon 98. Oxidative DNA damage by cytotoxic N-oxides of 1-hydroxyphenazine: Toward a molecular understanding of the bacterial virulence factor 1-hydroxyphenazine, S. Sinha and K. Gates 99. Potential health impacts of silver nanoparticles, P. V. N. Asharani, Z. Gong, M. P. Hande, and S. Valiyaveettil 100. Probing the aminofluorene-induced conformational heterogeneity in a simulated translesion synthesis by 19F NMR and differential scanning calorimetry, F. Liang and B. Cho 101. Protein adduction by reactive lipid oxidation-derived electrophiles, S. G. Codreanu, B. Zhang, J. S. Myers, S. M. Sobecki, D. D. Billheimer, and D. C. Liebler 102. Proteomic analysis of Azido-HNE adducted proteins in RKO cells, A. Vila, K. A. Tallman, N. A. Porter, D. C. Liebler, and L. J. Marnett 103. Quantification of folate in whole blood by liquid chromatography tandem mass spectrometry, Y. Huang, Z. Lu, A. S. Whitehead, and I. Blair 104. Redox regulation of protein tyrosine phosphatase 1B function by an organic peroxide, S. Bhattacharyya and K. S. Gates 105. Role of Z-DNA in arylhydrazine carcinogenesis, V. Vongsutilers and P. M. Gannett 106. Rule based approach for prediction of rabbit eye and skin irritation, P. J. Jurgutis, R. Didziapetris, and P. Japertas 107. Sequence effects on the NarI-derived frameshift mutagenesis by 19F NMR, DSC, and CD spectroscopy, N. Jain, S. R. Meneni, and B. Cho 108. Serial analysis of mutation spectra (SAMS): A new approach for the determination of mutation spectra and their sequence dependence, H. Fang and J.-S. Taylor 109. Shoot the messenger: c-Jun-N-terminal kinase (JNK) and nuclear factor-kappaB (NF-κB) pathway components are sensors for reactive electrophiles, H. L. Wong, J. S. Myers, S. G. Codreanu, C. R. Orton, M. E. Szapacs, R. W. Ganster, D. W. Ballard, and D. C. Liebler

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110. Structural characterization of 1,N2-ethenodeoxyguanosine in the dodecamer 5′-CGCATethenoGGAATCC3′, G. Shammugam, I. D. Kozekov, F. P. Guengerich, C. J. Rizzo, and M. P. Stone 111. Studies on N1-inosine and N6-adenine adducts in mice after inhalation exposures to 1,3-butadiene, G. Boysen, M. Troutman, L. B. Collins, and J. Swenberg 112. Synthesis and conformational characterization of the oligodeoxynucleotide duplexes modified by the model carcinogen fluoroaminobiphenyl, V. Biyyala, N. Jain, and B. Cho 113. Synthesis of alpha-methylene-deoxynucleotide triphosphates (alpha-m-dNTP) as noncleavable substrates for polymerases, F. Liang, N. Jain, A. S. P. Gowda, T. E. Spratt, and B. Cho 114. In vitro replication study of an intrastrand crosslink lesion G[8-5m]T and 8-oxo-2′-deoxyguanosine/ thymidine glycol tandem lesion, Y. Jiang and Y. Wang 115. Systematic study of 2′-deoxyoxanosine formation during nitrosative deamination of 2′-deoxyguanosine under biologically relevant conditions, J. L. McFaline, B. Pang, M. R. Sullivan, and P. C. Dedon 116. Toxico-cheminformatics and QSPR modeling of the carcinogenic potency database, K. Wang, A. Richard, I. Rusyn, and A. Tropsha 117. Translesion DNA synthesis across pyrimido[1,2-R]purin-10(3H)-one adduct by human DNA polymerase Pol η, M. A. Kalam, C. J. Rizzo, F. P. Guengerich, and L. J. Marnett 118. Translesion synthesis past the Me-FAPy adduct in oligonucleotides by DNA polymerases, P. P. Christov, I. D. Kozekov, K. L. Brown, M. P. Stone, T. M. Harris, and C. J. Rizzo 119. Unambiguous detection and quantification of 3-(2-deoxy-β-D-erythro-pentofuranosyl)-4,6,7,8-tetrahydro6-hydroxy-pyrimido[1,2-a]purin-10(3H)-one (6-HO-PdG) from the reaction of acrolein with calf thymus DNA, G. R. Alas, I. D. Kozekov, C. M. Harris, T. M. Harris, and C. J. Rizzo 120. Nitric oxide-induced deamidation retards and reverses fibril formation by an oligo(glutamine/asparagine) peptide, L. Kong, J. E. Saavedra, K. Nagashima, J. zheng, A. Patri, and L. K. Keefer

Wednesday Morning BCEC—258C. Mass Spectrometry of DNA and Protein Damages Y. Wang, Organizer 8:10—121. DNA adducts and you: When bad things happen to good cells, J. Glick, H. Zarbl, and P. Vouros 8:45—122. Oxidative stress as a component of aging and disease, F. Regnier 9:20—123. Oxidative stress-mediated DNA damage, I. A. Blair, S. H. Lee, D. Mangal, J. H. Park, and T. M. Penning 9:55— Intermission 10:10—124. Protein interaction with anticancer platinum drugs, X -F. X. Li, R. R. Mandal, and M. B. Sawyer 10:45—125. When good cholesterol goes bad: Mass spectrometric approaches for the analysis of dysfunctional HDL, J. Heinecke 11:20—126. Mass spectrometry for the identification and quantification of new types of oxidative DNA lesions, Y. Wang, H. Hong, H. Cao, and C. Gu

Wednesday Afternoon BCEC—258C. General Papers K. S. Gates, Organizer 1:00—127. Role of dietary components on acrylamide induced neurotransmitter turnover alterations in PC 12 cells, E. Tareke, S. Ali, B. Lyn-Cook, and H. M. Duhart 1:15—128. Influence of nanoparticles on soil microbial community, V. Shah and I. Belozerova 1:30—129. Problems with the use of risk-assessment approaches to estimate differences in health risks from various smoking products, J. H. Lauterbach 1:45—130. Identification and quantitative analysis of bifunctional DNA adducts of 1,2,3,4-diepoxybutane, N. Tretyakova, U. Seneviratne, and M. Goggin 2:00—131. Structure–function relationships in the recognition and DNA repair of bulky lesions by the human nucleotide excision repair apparatus, N. E. Geacintov, K. Kropachev, M. Kolbanovskiy, F. A. Rodriguez, Y. Cai, L. Zhang, Y. Tang, A. Kolbanovskiy, D. J. Patel, and S. Broyde 2:15—132. Natural terpenone analogs as a novel class of chemoprevention agents, Q. Zhou, L. Zhang, and J. K. Stewart 2:30—133. NMR characterization of duplex DNA containing an aristolochic acid II lesion, M. Lukin, T. Zaliznyak, R. R. Bonala, F. Johnson, and C. De los Santos 2:45—Intermission 3:00—134. Mechanism of 8-hydroxyguanine metabolism and incorporation into DNA and RNA: A novel route to mutagenesis from reactive oxygen species, P. T. Henderson

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3:15—135. Mechanisms of DNA polymerase-catalyzed bypass of N -(7,8,9,10-tetrahydrobenzo[a]pyren-10yl)-2′-deoxyguanosine, A. S. P. Gowda, L. R. DeCarlo, J. Krzeminski, S. Amin, Z. Suo, and T. E. Spratt 3:30—136. Liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of 7-ethylguanine in human liver, L. Chen, M. Wang, P. W. Villalta, and S. S. Hecht 3:45—137. Effects of arachidonic acid peroxyl radicals on the fates and end-products of guanine neutral radicals, C. Crean, N. E. Geacintov, and V. Shafirovich 4:00—138. In vitro and in vivo metabolism of a novel p38 kinase inhibitor, K. Mitra, K. Samuel, S. Natarajan, and S. Kumar 4:15—139. Aldo-keto reductases (AKR) and the metabolic activation of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-dihydrodiol) in human lung adenocarcinoma (A549) cells, T. M. Penning, J -H. Park, K. A. Tacka, A. M. Quinn, D. Mangal, and I. A. Blair 4:30—140. In silico predictive tools for screening hERG activity in early drug discovery, C. Gavaghan, I. Belda, L. Carlsson, H. Donner, and S. Boyer

Thursday Morning BCEC—258C. Systems-Wide Approaches To Understanding Drug Action and Toxicity Cosponsored by BIOHW J. Kotz, Organizer 8:30—Introductory remarks 8:40—141. Chemical biology on PINs and NeeDLes, S. W. Michnick 9:20—142. Network-level analysis of kinase inhibitors, F. M. White 10:00—143. The connectivity map: Using gene-expression profiling to identify new therapeutics and potential adverse drug effects, J. Lamb 10:40—144. Profiling small molecules, assay measurements, and cell states using the principles underlying ChemBank, P. A. Clemons 11:20—145. Understanding gene function and drug action, G. Giaever TX700251D