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Tremor-Producing Aminopropanols J. I ~ E N X E HORSER, TH LEOS OTIS, ASD W. A. SKINNEIZ Slunjord ir‘eaeurch Inslilule, Department of Pharmaceutical Chemistry, Menlo I’urlc, (‘ulifOr&
Received September 20, 1966 Revised Manuscript Received December 12, 1966 Twenty-one aminopropanols were prepared for testing as tremorogeiiic agents in mice. Efficiency of tremor detection by observation and by w e of an electronic tremor detector were compared. The tremor detector made possible the quantitative detection of slight, tremors which were not visually detect,able. Time-activity data are presented for the aminopropanols, and data on antagonism studies with tremorine-scopolamine and tremorine-amphetamine are presented.
Trciiior has been defined as oscillatory motion involving a part of the body that is moved by skeletal lllu5clC.’ This trembling or shaking may be regular or irregular, fine or gross, constant or periodic, and present a t rest or with activity.* In humans, tremor is frequently associated with frontal lobe tumor, hysteria, l’arliinson’s disease, cerebellar abscess, multiple sclerosis, and hyperthyroidism. Tremors are knonn to be induced in experimental animals by a number of comConpounds including certain amino alcohols. versely, some aminopropariols, including 3-dimethylhave amino-1-phen yl- 1-(3-met hoxyphen yl ) propanol, been patented as antispasmodics5 and antiparkirisoriism drugs. , I variety of aminopropariols of type 1 were prepared i i i this laboratory and their tremorogenic properties were evaluated in mice. These compounds were -CH-CHz-C -K-
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